Revisiting the displacement operator for quantum systems with position-dependent mass

Recently R. N. Costa Filho et al. (PRA 84, 050102(R) (2011)) have introduced a position dependent infinitesimal translation operator which corresponds to a position dependent linear momentum and consequently to a position dependent effective mass quantum particle. Although there is no doubt in novelty of the idea and the formalism, we believe that some aspects of the quantum mechanics could be complemented in their original work. Here in this letter first we address those points and then an alternative will be introduced. Finally we apply the formalism for a quantum particle under a null potential confined in a square well and the results will be compared with those in the paper mentioned above.Comment: 4 pages, 3 figures. Final version to appear in Phys. Rev.

Origin of spatial organization of DNA-polymer in bacterial chromosomes

In-vivo DNA organization at large length scales ($\sim 100nm$) is highly debated and polymer models have proved useful to understand the principle of DNA-organization. Here, we show that $<2$% cross-links at specific points in a ring polymer can lead to a distinct spatial organization of the polymer. The specific pairs of cross-linked monomers were extracted from contact maps of bacterial DNA. We are able to predict the structure of 2 DNAs using Monte Carlo simulations of the bead-spring polymer with cross-links at these special positions. Simulations with cross-links at random positions along the chain show that the organization of the polymer is different in nature from the previous case.Comment: arXiv admin note: text overlap with arXiv:1701.0506

Equality and Value-holism

In this paper, I consider a recent challenge to egalitarianism raised by Michael Huemer. Huemer?s challenge takes the form of a dilemma: egalitarians can either be atomists or holists about equality?s value. If they are atomists, then they must accept that equality in fact does not have intrinsic value; if they are holists, then their view will be inconsistent with an intuitively very plausible form of consequentialism. I show that this dilemma should not trouble egalitarians. Egalitarians can be holists about value and still embrace consequentialism

The Integrity of Religious Believers

According to Cécile Laborde, persons with religious commitments that are incidentally burdened by generally applicable laws should, under certain circumstances, be provided with an exemption from those laws. Labore’s justification for this view is that religious commitments are a type of commitment with which a person must comply if she is to maintain her integrity. I argue that Laborde´s account is insufficiently demanding in terms of the other-regarding attitudes it expects people to have before they can make claims to exemptions based on their integrity. The reason for this is that Laborde’s account rests on what I call a ‘non-moralised’ view of integrity. I raise some criticisms of this view and defend an alternative, ‘moralised’ view of integrity, according to which a religious person’s integrity depends on whether the practice she wishes to perform complies with certain moral constraints

Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells

It is now recognized that small noncoding RNA sequences have the ability to mediate transcriptional activation of specific target genes in human cells. Using bioinformatics analysis and functional screening, we screened short-activating RNA (saRNA) oligonucleotides designed to target the promoter regions of the pluripotency reprogramming factors, Kruppel-like factor 4 (KLF4) and c-MYC. We identified KLF4 and c-MYC promoter-targeted saRNA sequences that consistently induced increases in their respective levels of nascent mRNA and protein expression in a time- and dose-dependent manner, as compared with scrambled sequence control oligonucleotides. The functional consequences of saRNA-induced activation of each targeted reprogramming factor were then characterized by comprehensively profiling changes in gene expression by microarray analysis, which revealed significant increases in mRNA levels of their respective downstream pathway genes. Notably, the microarray profile after saRNA-mediated induction of endogenous KLF4 and c-MYC showed similar gene expression patterns for stem cell- and cell cycle-related genes as compared with lentiviral vector-mediated overexpression of exogenous KLF4 and c-MYC transgenes, while divergent gene expression patterns common to viral vector-mediated transgene delivery were also noted. The use of promoter-targeted saRNAs for the activation of pluripotency reprogramming factors could have broad implications for stem cell research

Higher dimensional thin-shell wormholes in Einstein-Yang-Mills-Gauss-Bonnet gravity

We present thin-shell wormhole solutions in Einstein-Yang-Mills-Gauss-Bonnet (EYMGB) theory in higher dimensions d\geq5. Exact black hole solutions are employed for this purpose where the radius of thin-shell lies outside the event horizon. For some reasons the cases d=5 and d>5 are treated separately. The surface energy-momentum of the thin-shell creates surface pressures to resist against collapse and rendering stable wormholes possible. We test the stability of the wormholes against spherical perturbations through a linear energy-pressure relation and plot stability regions. Apart from this restricted stability we investigate the possibility of normal (i.e. non-exotic) matter which satisfies the energy conditions. For negative values of the Gauss-Bonnet (GB) parameter we obtain such physical wormholes.Comment: 9 pages, 6 figures. Dedicated to the memory of Rev. Ibrahim Eken (1927-2010) of Turke

Anisotropic low-temperature piezoresistance in (311)A GaAs two-dimensional holes

We report low-temperature resistance measurements in a modulation-doped, (311)A GaAs two-dimensional hole system as a function of applied in-plane strain. The data reveal a strong but anisotropic piezoresistance whose magnitude depends on the density as well as the direction along which the resistance is measured. At a density of $1.6\times10^{11}$ cm$^{-2}$ and for a strain of about $2\times10^{-4}$ applied along [01$\bar{1}$], e.g., the resistance measured along this direction changes by nearly a factor of two while the resistance change in the [$\bar{2}$33] direction is less than 10% and has the opposite sign. Our accurate energy band calculations indicate a pronounced and anisotropic deformation of the heavy-hole dispersion with strain, qualitatively consistent with the experimental data. The extremely anisotropic magnitude of the piezoresistance, however, lacks a quantitative explanation.Comment: 4 pages. Submitted to Applied Physics Letter