Study of the turbulent mixing zone induced by the Richtmyer-Meshkov instability using Laser Doppler Velocimetry and Schlieren visualizations

An experimental study of the compressible mixing generated by the Richtmyer-Meshkov instability (RMI) is carried out in a vertical shock tube by means of two-components Laser Doppler Velocimetry (2C-LDV) measurements and Time-resolved Schlieren visualizations. An attempt is made to quantify the RMI-induced air/sulphurhexafluoride (SF6) mixing by measuring turbulence levels inside the mixing zone at a given stage of its development and by extracting the growth rate of the mixing zone from the Schlieren images

Experimental determination of the growth rate of Richtmyer-Meshkov induced turbulent mixing after reshock

The time evolution of the width of the turbulent mixing zone arising from the late development of Richtmyer-Meshkov instability is investigated in this work. This is achieved by means of the analysis of time-resolved Schlieren images obtained with a given set of shock-tube experiments. The post-reshock growth rate of the mixing zone width is found to be nearly insensitive to the development state of the mixing at the time of reshock

LDV measurements in turbulent gaseous mixing induced by the Richtmyer-Meshkov instability: statistical convergence issues and turbulence quantification

A statistical characterization of the turbulent flow produced in a vertical shock tube dedicated to the study of the Richtmyer-Meshkov instability (RMI) is carried out using Laser Doppler Velocimetry (LDV), time-resolved Schlieren images and pressure histories. The time evolution of the phase-averaged velocity field and the fluctuating velocity levels produced behind the shock wave are first investigated for different configurations of a pure air, homogeneous medium. This allows us to determine the background turbulence of the experimental apparatus. Second, the RMI-induced turbulent Air/SF6 mixing zone (TMZ) is studied both in its early stage of development and after its interaction with a reflected shock wave (reshock phenomenon). Here the gaseous interface is initially produced by a thin nitrocellulosic membrane trapped between two grids. One of the most consistent issue regarding such a process is the generation of a large number of fragments when the incident shock wave crosses the interface. These fragments are likely to corrupt the optical measurements and to interact with the flow. This work seeks to clarify the influence of these fragments on the statistical determination of the velocity field. In particular it is shown that statistical convergence cannot be achieved when the fragments are crossing the LDV measurement volume, even if a significant number of identical experiments are superimposed. Some specific locations for the LDV measurements are however identified to be more favourable than others in the Air/SF6 mixing configuration. This finally allows us to quantify the surplus of turbulence induced by the reshock phenomenon

Cancer treatment and survival among cervical cancer patients living with or without HIV in South Africa.

Objective To compare cancer treatment and all-cause mortality between HIV-positive and HIV-negative cervical cancer patients in South Africa. Methods We assessed cancer treatment and all-cause mortality in HIV-positive and HIV-negative cervical cancer patients who received cancer treatment within 180 days of diagnosis using reimbursement claims data from a private medical insurance scheme in South Africa between 01/2011 and 07/2020. We assessed treatment provision using logistic regression and factors associated with all-cause mortality using Cox regression. We assigned missing values for histology and ethnicity using multiple imputation. Results Of 483 included women, 136 (28 %) were HIV-positive at cancer diagnosis (median age: 45.7 years), and 347 (72 %) were HIV-negative (median age: 54.1 years). Among 285 patients with available ICD-O-3 morphology claims codes, the proportion with cervical adenocarcinoma was substantially lower in HIV-positive (4 %) than in HIV-negative patients (26 %). Most HIV-positive patients (67 %) were on antiretroviral therapy at cancer diagnosis. HIV-positive patients were more likely to receive radiotherapy (adjusted odds ratio [aOR] 1.90, 95 % confidence interval [CI] 1.05-3.45) or chemotherapy (aOR 2.02, 95 %CI 0.92-4.43) and less likely to undergo surgery (aOR 0.53, 95 %CI 0.31-0.90) than HIV-negative patients. HIV-positive patients were at a higher risk of death from all causes than HIV-negative patients (adjusted hazard ratio 1.52, 95 %CI 1.06-2.19). Other factors associated with higher all-cause mortality included age > 60 years and metastases at diagnosis. Conclusions HIV-positive cervical cancer patients in South Africa had higher all-cause mortality than HIV-negative patients which could be explained by differences in tumour progression, clinical care, and HIV-specific mortality

Experimental and numerical investigation of the growth of an air/SF6 turbulent mixing zone in a shock tube

Shock-induced mixing experiments have been conducted in a vertical shock tube of 130mm square cross section located at ISAE. A shock wave traveling at Mach 1.2 in air hits a geometrically disturbed interface separating air and SF6, a gas five times heavier than air, filling a chamber of length L up to the end of the shock tube. Both gases are initially separated by a 0.5 lm thick nitrocellulose membrane maintained parallel to the shock front by two wire grids: an upper one with mesh spacing equal to either ms=1.8mm or 12.1 mm, and a lower one with a mesh spacing equal to ml=1 mm. Weak dependence of the mixing zone growth after reshock (interaction of the mixing zone with the shock wave reflected from the top end of the test chamber) with respect to L and ms is observed despite a clear imprint of the mesh spacing ms in the schlieren images. Numerical simulations representative of these configurations are conducted: the simulations successfully replicate the experimentally observed weak dependence on L, but are unable to show the experimentally observed independence with respect to ms while matching the morphological features of the schlieren pictures

Developing a French FrameNet: Methodology and First results

International audienceThe Asfalda project aims to develop a French corpus with frame-based semantic annotations and automatic tools for shallow semantic analysis. We present the first part of the project: focusing on a set of notional domains, we delimited a subset of English frames, adapted them to French data when necessary, and developed the corresponding French lexicon. We believe that working domain by domain helped us to enforce the coherence of the resulting resource, and also has the advantage that, though the number of frames is limited (around a hundred), we obtain full coverage within a given domain

A new approach for the comprehensive study of a turbulent mixing zone induced by the Richtmyer-Meshkov instability

In this study we propose a new experimental and methodological approach dedicated to the analysis of the development of a turbulent mixing zone produced by the Richtmyer-Meshkov Instability. A brief description of the experimental device dedicated to the generation of the initial interface is first presented. An overview of the main results obtained by means of strioscopic, Particle Image Velocimetry (PIV) and tomoscopic time-resolved measurements are then provided. The spatio-temporal evolution of the macroscopic scale based on the thickness of the mixing zone is discussed on the basis of the time-resolved Schlieren data. A first step into a more comprehensive analysis of finer, local scales of the flow is introduced, based on the qualitative analysis of the velocity and density fields during the development of the mixing zone

CeRebrUm and CardIac Protection with ALlopurinol in Neonates with Critical Congenital Heart Disease Requiring Cardiac Surgery with Cardiopulmonary Bypass (CRUCIAL):study protocol of a phase III, randomized, quadruple-blinded, placebo-controlled, Dutch multicenter trial

BACKGROUND: Neonates with critical congenital heart disease (CCHD) undergoing cardiac surgery with cardiopulmonary bypass (CPB) are at risk of brain injury that may result in adverse neurodevelopment. To date, no therapy is available to improve long-term neurodevelopmental outcomes of CCHD neonates. Allopurinol, a xanthine oxidase inhibitor, prevents the formation of reactive oxygen and nitrogen species, thereby limiting cell damage during reperfusion and reoxygenation to the brain and heart. Animal and neonatal studies suggest that allopurinol reduces hypoxic-ischemic brain injury and is cardioprotective and safe. This trial aims to test the hypothesis that allopurinol administration in CCHD neonates will result in a 20% reduction in moderate to severe ischemic and hemorrhagic brain injury. METHODS: This is a phase III, randomized, quadruple-blinded, placebo-controlled, multicenter trial. Neonates with a prenatal or postnatal CCHD diagnosis requiring cardiac surgery with CPB in the first 4 weeks after birth are eligible to participate. Allopurinol or mannitol-placebo will be administered intravenously in 2 doses early postnatally in neonates diagnosed antenatally and 3 doses perioperatively of 20 mg/kg each in all neonates. The primary outcome is a composite endpoint of moderate/severe ischemic or hemorrhagic brain injury on early postoperative MRI, being too unstable for postoperative MRI, or mortality within 1 month following CPB. A total of 236 patients (n = 188 with prenatal diagnosis) is required to demonstrate a reduction of the primary outcome incidence by 20% in the prenatal group and by 9% in the postnatal group (power 80%; overall type 1 error controlled at 5%, two-sided), including 1 interim analysis at n = 118 (n = 94 with prenatal diagnosis) with the option to stop early for efficacy. Secondary outcomes include preoperative and postoperative brain injury severity, white matter injury volume (MRI), and cardiac function (echocardiography); postnatal and postoperative seizure activity (aEEG) and regional cerebral oxygen saturation (NIRS); neurodevelopment at 3 months (general movements); motor, cognitive, and language development and quality of life at 24 months; and safety and cost-effectiveness of allopurinol. DISCUSSION: This trial will investigate whether allopurinol administered directly after birth and around cardiac surgery reduces moderate/severe ischemic and hemorrhagic brain injury and improves cardiac function and neurodevelopmental outcome in CCHD neonates. TRIAL REGISTRATION: EudraCT 2017-004596-31. Registered on November 14, 2017. ClinicalTrials.gov NCT04217421. Registered on January 3, 2020 SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13063-022-06098-y