Microlens array on flip-chip LED patterned with an ultraviolet micro-pixelated emitter

A direct-write lithographic technique for the fabrication of micro-lens arrays with an ultraviolet (UV) micro-light-emitting diode (LED) array serving as an exposure source is reported. Polymer microlens arrays of high optical quality have been fabricated on the sapphire side of a flip-chip truncated-conic (TC) LED. The properties of the lenses are evaluated by optical microscopy and atomic force microscopy. The determined focal length is close to the predicted value. The effects of microlens integration on the optical properties of the LED are investigated. © 2011 IEEE.published_or_final_versio

Angularly uniform white light-emitting diodes using an integrated reflector cup

We report on white light-emitting diodes (LEDs) with a truncated-conical (TC) geometry produced by laser micromachining. A blue LED was shaped into a circular disc with 50°-inclined sidewall using a modified laser micromachining setup. A layer of Al was coated onto the inclined sidewall and the bottom surface to form an integrated reflector. Due to the highly reflective mirror, laterally propagating photons are redirected into the upward direction, contributing to an increase of 21.7% of light intensity in the normal direction. With quantum dots applied to the surface, white light emission from this TC-LED structure demonstrated a 37% enhancement in color uniformity, compared with a conventional device. © 2010 IEEE.published_or_final_versio

Fiber-coupled light-emitting diode with a capillary-bonded hemispherical lens

A hemispherical lens capillary-bonded to an InGaN flip-chip light-emitting diode (LED) is demonstrated to efficiently couple light to a plastic optical fiber. The BK-7 hemispherical lens is bonded onto a circularly shaped LED chip with inclined sidewalls cut by laser-micromachining, so that lateral emissions are effectively suppressed. Capillary bonding minimizes air-gap between chip and lens enabling transmission of evanescent waves, thus maximizing overall optical transmission. With the lens attached, emission divergence from the assembly is significantly reduced, diverting rays into the acceptance cone of the fiber. Fiber coupling efficiency as high as 53.8% has been demonstrated. © 2011 IEEE.published_or_final_versio

Vertically mounted InGaN-on-Sapphire light-emitting diodes

An InGaN/GaN light-emitting diode (LED) chip mounted in a vertical configuration (vmLED) is demonstrated, exhibiting significant enhancement to light extraction, compared with a LED mounted in a conventional planar geometry. By flipping the chip orthogonally, two large illumination surfaces of the device are exposed for direct light extraction. Comparisons, through ray-trace modeling and experiment data with conventional surface-mounted LEDs, indicate that the vmLEDs achieve superior light extraction efficiency. A sapphire-prism-mounted vmLED is further proposed to improve heat sinking, which is well suited for higher current operations. © 2006 IEEE.published_or_final_versio

Pixel-to-pixel fiber-coupled emissive micro-light-emitting diode arrays

We report on an integrated fiber-coupled bi-linear micro-light-emitting diode array, serving as a portable microdisplay system. The fiber bundle transforms the bi-linearly arranged optical signals from the emissive array into a 6-by-8 pixel microdisplay, offering a crisp and clear optical output. The pixel-to-pixel coupling arrangement ensures optical coupling efficiency. Due to the narrow acceptance cones of optical fibers, individual pixels can be well resolved with minimal crosstalk. The performance and functionality of this optical system is fully evaluated. A model to determine the fiber-coupling efficiency was constructed; it was found that the simulated results compare well with the measured data.published_or_final_versio

Enhanced powder dispersion of dual-excipient spray-dried powder formulations of a monoclonal antibody and its fragment for local treatment of severe asthma

The advent of biologics has brought renewed hope for patients with severe asthma, a condition notorious for being hampered by poor response to conventional therapies and adverse drug reactions owing to corticosteroid dependence. However, biologics are administered as injections, thereby precluding the benefits inhalation therapy could offer such as increased bioavailability at the site of action, minimal systemic side effects, non-invasiveness, and self-administration. Here, 2-hydroxypropyl-beta-cyclodextrin and ʟ-leucine were co-spray-dried, as protein stabiliser and dispersion enhancer, respectively, at various weight ratios to produce a series of formulation platforms. Powder aerosolisation characteristics and particle morphology were assessed for suitability for pulmonary delivery. The selected platform with the best aerosol performance, a 1:1 ratio of the excipients, was then incorporated with a monoclonal antibody directed against IL-4 receptor alpha or its antigen-binding fragment. The dual-excipient antibody formulations exhibited emitted fraction of at least 80% and fine particle fraction exceeding 60% in cascade impactor study, while the residual moisture content was within a desirable range between 1% and 3%. The in vitro antigen-binding ability and inhibitory potency of the spray-dried antibody were satisfactorily preserved. The results from this study corroborate the viability of inhaled solid-state biomacromolecules as a promising treatment approach for asthma

Novel deformation-induced polymorphic crystallization and softening of Al-based amorphous alloys

© 2018 Acta Materialia Inc. Melt-spun amorphous ribbons of Al 90 Y 10 (at.%) (90Al) and Al 84 Y 8.5 Ni 4 Co 2 Pd 1 Fe 0.5 (84Al) are cold-rolled at near to liquid-nitrogen temperature or at room temperature, inducing partial crystallization to nanoscale fcc-Al (α-Al). The crystallization is characterized and contrasted with the distinct sequences of reactions on annealing 90Al and 84Al amorphous alloys. Rolling-induced crystallization leads to softening, opposite to the effect of nanocrystallization induced by annealing. The origins of the hardness changes are analyzed. The rolling induces novel polymorphic crystallization to α-Al with extended solid solubility. This transformation, which occurs equally in 84Al and 90Al, despite the much greater thermal stability of the former, allows the ribbons to retain good bending ductility, and delays the onset of embrittlement on subsequent annealing. Partial crystallization induced by cold-rolling is useful in avoiding the formation of compound phases associated with brittleness, and is a promising process for high-solute Al-based amorphous alloys to be further developed as structural materials

Oral carriage of yeasts and coliforms in stroke sufferers

published_or_final_versio

Continuum-scale modelling of polymer blends using the Cahn-Hilliard equation: transport and thermodynamics

The Cahn–Hilliard equation is commonly used to study multi-component soft systems such as polymer blends at continuum scales. We first systematically explore various features of the equation system, which give rise to a deep connection between transport and thermodynamics-specifically that the Gibbs free energy of mixing function is central to formulating a well-posed model. Accordingly, we explore how thermodynamic models from three broad classes of approach (lattice-based, activity-based and perturbation methods) can be incorporated within the Cahn–Hilliard equation and examine how they impact the numerical solution for two model polymer blends, noting that although the analysis presented here is focused on binary mixtures, it is readily extensible to multi-component mixtures. It is observed that, although the predicted liquid–liquid interfacial tension is quite strongly affected, the choice of thermodynamic model has little influence on the development of the morphology

Centralizer's applications to the (b, c)-inverses in rings

[EN] We give several conditions in order that the absorption law for one sided (b,c)-inverses in rings holds. Also, by using centralizers, we obtain the absorption law for the (b,c)-inverse and the reverse order law of the (b,c)-inverse in rings. As applications, we obtain the related results for the inverse along an element, Moore-Penrose inverse, Drazin inverse, group inverse and core inverse.This research is supported by the National Natural Science Foundation of China (no. 11771076 and no. 11871301). The first author is grateful to China Scholarship Council for giving him a scholarship for his further study in Universitat Politecnica de Valencia, Spain.Xu, S.; Chen, J.; Benítez López, J.; Wang, D. (2019). Centralizer's applications to the (b, c)-inverses in rings. Revista de la Real Academia de Ciencias Exactas, Físicas y Naturales. 113(3):1739-1746. https://doi.org/10.1007/s13398-018-0574-0S173917461133Baksalary, O.M., Trenkler, G.: Core inverse of matrices. Linear Multilinear Algebra 58(6), 681–697 (2010)Benítez, J., Boasso, E.: The inverse along an element in rings with an involution, Banach algebras and $$C^*$$ C ∗ -algebras. Linear Multilinear Algebra 65(2), 284–299 (2017)Benítez, J., Boasso, E., Jin, H.W.: On one-sided $$(B, C)$$ ( B , C ) -inverses of arbitrary matrices. Electron. J. Linear Algebra 32, 391–422 (2017)Boasso, E., Kantún-Montiel, G.: The $$(b, c)$$ ( b , c ) -inverses in rings and in the Banach context. Mediterr. J. Math. 14, 112 (2017)Chen, Q.G., Wang, D.G.: A class of coquasitriangular Hopf group algebras. Comm. Algebra 44(1), 310–335 (2016)Chen, J.L., Ke, Y.Y., Mosić, D.: The reverse order law of the $$(b, c)$$ ( b , c ) -inverse in semigroups. Acta Math. Hung. 151(1), 181–198 (2017)Deng, C.Y.: Reverse order law for the group inverses. J. Math. Anal. Appl. 382(2), 663–671 (2011)Drazin, M.P.: Pseudo-inverses in associative rings and semigroups. Am. Math. Mon. 65, 506–514 (1958)Drazin, M.P.: A class of outer generalized inverses. Linear Algebra Appl. 436, 1909–1923 (2012)Drazin, M.P.: Left and right generalized inverses. Linear Algebra Appl. 510, 64–78 (2016)Jin, H.W., Benítez, J.: The absorption laws for the generalized inverses in rings. Electron. J. Linear Algebra 30, 827–842 (2015)Johnson, B.E.: An introduction to the theory of centralizers. Proc. Lond. Math. Soc. 14, 299–320 (1964)Ke, Y.Y., Cvetković-Ilić, D.S., Chen, J.L., Višnjić, J.: New results on $$(b, c)$$ ( b , c ) -inverses. Linear Multilinear Algebra 66(3), 447–458 (2018)Ke Y.Y., Višnjić J., Chen J.L.: One sided $$(b,c)$$ ( b , c ) -inverse in rings (2016). arXiv:1607.06230v1Liu, X.J., Jin, H.W., Cvetković-Ilić, D.S.: The absorption laws for the generalized inverses. Appl. Math. Comput. 219, 2053–2059 (2012)Mary, X.: On generalized inverse and Green’s relations. Linear Algebra Appl. 434, 1836–1844 (2011)Mary, X., Patrício, P.: Generalized inverses modulo $$\cal{H}$$ H in semigroups and rings. Linear Multilinear Algebra 61(8), 1130–1135 (2013)Mosić, D., Cvetković-Ilić, D.S.: Reverse order law for the Moore-Penrose inverse in $$C^*$$ C ∗ -algebras. Electron. J. Linear Algebra 22, 92–111 (2011)Rakić, D.S.: A note on Rao and Mitra’s constrained inverse and Drazin’s $$(b, c)$$ ( b , c ) -inverse. Linear Algebra Appl. 523, 102–108 (2017)Rakić, D.S., Dinčić, N.Č., Djordjević, D.S.: Group, Moore–Penrose, core and dual core inverse in rings with involution. Linear Algebra Appl. 463, 115–133 (2014)Wang, L., Castro-González, N., Chen, J.L.: Characterizations of outer generalized inverses. Can. Math. Bull. 60(4), 861–871 (2017)Wei, Y.M.: A characterization and representation of the generalized inverse $$A^{(2)}_{T, S}$$ A T , S ( 2 ) and its applications. Linear Algebra Appl. 280, 87–96 (1998)Xu, S.Z., Benítez, J.: Existence criteria and expressions of the $$(b, c)$$ ( b , c ) -inverse in rings and its applications. Mediterr. J. Math. 15, 14 (2018)Zhu, H.H., Chen, J.L., Patrício, P.: Further results on the inverse along an element in semigroups and rings. Linear Multilinear Algebra 64(3), 393–403 (2016)Zhu, H.H., Chen, J.L., Patrício, P.: Reverse order law for the inverse along an element. Linear Multilinear Algebra 65, 166–177 (2017)Zhu, H.H., Chen, J.L., Patrício, P., Mary, X.: Centralizer’s applications to the inverse along an element. Appl. Math. Comput. 315, 27–33 (2017)Zhu, H.H., Zhang, X.X., Chen, J.L.: Centralizers and their applications to generalized inverses. Linear Algebra Appl. 458, 291–300 (2014