75 research outputs found
Molecular motors robustly drive active gels to a critically connected state
Living systems often exhibit internal driving: active, molecular processes
drive nonequilibrium phenomena such as metabolism or migration. Active gels
constitute a fascinating class of internally driven matter, where molecular
motors exert localized stresses inside polymer networks. There is evidence that
network crosslinking is required to allow motors to induce macroscopic
contraction. Yet a quantitative understanding of how network connectivity
enables contraction is lacking. Here we show experimentally that myosin motors
contract crosslinked actin polymer networks to clusters with a scale-free size
distribution. This critical behavior occurs over an unexpectedly broad range of
crosslink concentrations. To understand this robustness, we develop a
quantitative model of contractile networks that takes into account network
restructuring: motors reduce connectivity by forcing crosslinks to unbind.
Paradoxically, to coordinate global contractions, motor activity should be low.
Otherwise, motors drive initially well-connected networks to a critical state
where ruptures form across the entire network.Comment: Main text: 21 pages, 5 figures. Supplementary Information: 13 pages,
8 figure
Tipping Points in 1-dimensional Schelling Models with Switching Agents
Schelling’s spacial proximity model was an early agent-based model, illustrating how ethnic segregation can emerge, unwanted, from the actions of citizens acting according to individual local preferences. Here a 1-dimensional unperturbed variant is studied under switching agent dynamics, interpretable as being open in that agents may enter and exit the model. Following the authors’ work (Barmpalias et al., FOCS, 2014) and that of Brandt et al. (Proceedings of the 44th ACM Symposium on Theory of Computing (STOC 2012), 2012), rigorous asymptotic results are established. The dynamic allows either type to take over almost everywhere. Tipping points are identified between the regions of takeover and staticity. In a generalization of the models considered in [1] and [3], the model’s parameters comprise the initial proportions of the two types, along with independent values of the tolerance for each type. This model comprises a 1-dimensional spin-1 model with spin dependent external field, as well as providing an example of cascading behaviour within a network
Methylene Blue injection via superior mesenteric artery microcatheter for focused enterectomy in the treatment of a bleeding small intestinal arteriovenous malformation
A Review of One-Way and Two-Way Experiments to Test the Isotropy of the Speed of Light
As we approach the 125th anniversary of the Michelson-Morley experiment in
2012, we review experiments that test the isotropy of the speed of light.
Previous measurements are categorized into one-way (single-trip) and two-way
(round-trip averaged or over closed paths) approaches and the level of
experimental verification that these experiments provide is discussed. The
isotropy of the speed of light is one of the postulates of the Special Theory
of Relativity (STR) and, consequently, this phenomenon has been subject to
considerable experimental scrutiny. Here, we tabulate significant experiments
performed since 1881 and attempt to indicate a direction for future
investigation.Comment: Updated Fig. 7 and references; Revised sections 3.2 and 4. Accepted
in the Indian Journal of Physics on March 30, 201
The Biochemistry, Ultrastructure, and Subunit Assembly Mechanism of AMPA Receptors
The AMPA-type ionotropic glutamate receptors (AMPA-Rs) are tetrameric ligand-gated ion channels that play crucial roles in synaptic transmission and plasticity. Our knowledge about the ultrastructure and subunit assembly mechanisms of intact AMPA-Rs was very limited. However, the new studies using single particle EM and X-ray crystallography are revealing important insights. For example, the tetrameric crystal structure of the GluA2cryst construct provided the atomic view of the intact receptor. In addition, the single particle EM structures of the subunit assembly intermediates revealed the conformational requirement for the dimer-to-tetramer transition during the maturation of AMPA-Rs. These new data in the field provide new models and interpretations. In the brain, the native AMPA-R complexes contain auxiliary subunits that influence subunit assembly, gating, and trafficking of the AMPA-Rs. Understanding the mechanisms of the auxiliary subunits will become increasingly important to precisely describe the function of AMPA-Rs in the brain. The AMPA-R proteomics studies continuously reveal a previously unexpected degree of molecular heterogeneity of the complex. Because the AMPA-Rs are important drug targets for treating various neurological and psychiatric diseases, it is likely that these new native complexes will require detailed mechanistic analysis in the future. The current ultrastructural data on the receptors and the receptor-expressing stable cell lines that were developed during the course of these studies are useful resources for high throughput drug screening and further drug designing. Moreover, we are getting closer to understanding the precise mechanisms of AMPA-R-mediated synaptic plasticity
A Guide to Medications Inducing Salivary Gland Dysfunction, Xerostomia, and Subjective Sialorrhea: A Systematic Review Sponsored by the World Workshop on Oral Medicine VI
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