Ages on weathered Plio-Pleistocene tephra sequences, western North Island, New Zealand

Using the zircon fission-track method, we have obtained five ages on members of two strongly-weathered silicic, Pliocene-Pleistocene tephra sequences, the Kauroa and Hamilton Ash formations, in western North Island, New Zealand. These are the first numerical ages to be obtained directly on these deposits. Of the Kauroa Ash sequence, member K1 (basal unit) was dated at 2.24 ± 0.29 Ma, confirming a previous age of c. 2.25 Ma obtained (via tephrochronology)from K/Ar ages on associated basalt lava. Members K2 and K3 gave indistinguishable ages between 1.68 ± 0.12 and 1.43 ± 0.17 Ma. Member K12, a correlative of Oparau Tephra and probably also Ongatiti Ignimbrite, was dated at 1.28 ± 0.11 Ma, consistent with an age of 1.23 ± 0.02 Ma obtained by various methods on Ongatiti Ignimbrite. Palaeomagnetic measurements indicated that members K13 to K15 (top unit, Waiterimu Ash) are aged between c. 1.2 Ma and 0.78 Ma. Possible sources of the Kauroa Ash Formation include younger volcanic centres in the southern Coromandel Volcanic Zone or older volcanic centres in the Taupo Volcanic Zone, or both. Of the Hamilton Ash sequence, the basal member Ohinewai Ash (HI) was dated at 0.38 ± 0.04 Ma. This age matches those obtained by various methods on Rangitawa Tephra of 0.34-0.35 Ma, supporting correlation with this Whakamaru-caldera derived deposit. The origin of the other Hamilton Ash beds is unknown but various younger volcanic centres in the Taupo Volcanic Zone are possible sources. The topmost member, Tikotiko Ash (H6-H7), is estimated to be aged between c. 0.18 and 0.08 Ma. Various silicic pyroclastic deposits documented in North Island and in marine cores may be co-eval with members of the Kauroa Ash and Hamilton Ash sequences on the basis of their age

Arithmetically Cohen-Macaulay Bundles on complete intersection varieties of sufficiently high multidegree

Recently it has been proved that any arithmetically Cohen-Macaulay (ACM) bundle of rank two on a general, smooth hypersurface of degree at least three and dimension at least four is a sum of line bundles. When the dimension of the hypersurface is three, a similar result is true provided the degree of the hypersurface is at least six. We extend these results to complete intersection subvarieties by proving that any ACM bundle of rank two on a general, smooth complete intersection subvariety of sufficiently high multi-degree and dimension at least four splits. We also obtain partial results in the case of threefolds.Comment: 15 page

Neurology

Contains research objectives and reports on six research projects.National Science Foundation (Grant G-16526)National Institutes of Health (Grant MH-04737-03)U.S. Public Health Service (B-3055-3)U.S. Public Health Service (B-3090-3)U.S. Public Health Service (MH-06175-01A1)Office of Naval Research (Nonr-1841(70))Air Force (AFOSR 155-63)Army Chemical Corps (DA- 18-108-405-CML-942

Characterization of breast tissue using energy-dispersive X-ray diffraction computed tomography

Abstract A method for sample characterization using energy-dispersive X-ray diffraction computed tomography (EDXRDCT) is presented. The procedures for extracting diffraction patterns from the data and the corrections applied are discussed. The procedures were applied to the characterization of breast tissue samples, 6 mm in diameter. Comparison with histological sections of the samples confirmed the possibility of grouping the patterns into five families, corresponding to adipose tissue, fibrosis, poorly differentiated cancer, well differentiated cancer, and benign tumour

Insulin Glargine in the Intensive Care Unit: A Model-Based Clinical Trial Design

Online 4 Oct 2012Introduction: Current succesful AGC (Accurate Glycemic Control) protocols require extra clinical effort and are impractical in less acute wards where patients are still susceptible to stress-induced hyperglycemia. Long-acting insulin Glargine has the potential to be used in a low effort controller. However, potential variability in efficacy and length of action, prevent direct in-hospital use in an AGC framework for less acute wards. Method: Clinically validated virtual trials based on data from stable ICU patients from the SPRINT cohort who would be transferred to such an approach are used to develop a 24-hour AGC protocol robust to different Glargine potencies (1.0x, 1.5x and 2.0x regular insulin) and initial dose sizes (dose = total insulin over prior 12, 18 and 24 hours). Glycemic control in this period is provided only by varying nutritional inputs. Performance is assessed as %BG in the 4.0-8.0mmol/L band and safety by %BG<4.0mmol/L. Results: The final protocol consisted of Glargine bolus size equal to insulin over the previous 18 hours. Compared to SPRINT there was a 6.9% - 9.5% absolute decrease in mild hypoglycemia (%BG<4.0mmol/L) and up to a 6.2% increase in %BG between 4.0 and 8.0mmol/L. When the efficacy is known (1.5x assumed) there were reductions of: 27% BG measurements, 59% insulin boluses, 67% nutrition changes, and 6.3% absolute in mild hypoglycemia. Conclusion: A robust 24-48 clinical trial has been designed to safely investigate the efficacy and kinetics of Glargine as a first step towards developing a Glargine-based protocol for less acute wards. Ensuring robustness to variability in Glargine efficacy significantly affects the performance and safety that can be obtained

Stability of homogeneous bundles on P^3

We study the stability of some homogeneous bundles on P^3 by using their representations of the quiver associated to the homgeneous bundles on P^3. In particular we show that homogeneous bundles on P^3 whose support of the quiver representation is a parallelepiped are stable, for instance the bundles E whose minimal free resolution is of the kind 0 --> S^{l_1, l_2, l_3} V (t) --> S^{l_1 +s, l_2, l_3} V (t+s) --> E --> 0 are stable.Comment: to appear in Geometriae Dedicata http://www.springer.com/mathematics/geometry/journal/1071

Neurology

Contains reports on six research projects.United States Public Health Service (B-3055-4, B-3090-4, MH-06175-02)United States Navy, Office of Naval Research (Contract Nonr-1841(70))United States Air Force (AF49(638)-1313), administered by the Electronic Systems Laboratory, M. I. T

PLASMAPHERESIS IN RAYNAUD'S DISEASE

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22629/1/0000179.pd

The repulsive lattice gas, the independent-set polynomial, and the Lov\'asz local lemma

We elucidate the close connection between the repulsive lattice gas in equilibrium statistical mechanics and the Lovasz local lemma in probabilistic combinatorics. We show that the conclusion of the Lovasz local lemma holds for dependency graph G and probabilities {p_x} if and only if the independent-set polynomial for G is nonvanishing in the polydisc of radii {p_x}. Furthermore, we show that the usual proof of the Lovasz local lemma -- which provides a sufficient condition for this to occur -- corresponds to a simple inductive argument for the nonvanishing of the independent-set polynomial in a polydisc, which was discovered implicitly by Shearer and explicitly by Dobrushin. We also present some refinements and extensions of both arguments, including a generalization of the Lovasz local lemma that allows for "soft" dependencies. In addition, we prove some general properties of the partition function of a repulsive lattice gas, most of which are consequences of the alternating-sign property for the Mayer coefficients. We conclude with a brief discussion of the repulsive lattice gas on countably infinite graphs.Comment: LaTex2e, 97 pages. Version 2 makes slight changes to improve clarity. To be published in J. Stat. Phy

Response of soil health indicators to dung, urine and mineral fertilizer application in temperate pastures

Healthy soils are key to sustainability and food security. In temperate grasslands, not many studies have focused on soil health comparisons between contrasting pasture systems under different management strategies and treatment applications (e.g. manures and inorganic fertilisers). The aim of this study was to assess the responses of soil health indicators to dung, urine and inorganic N fertiliser in three temperate swards: permanent pasture not ploughed for at least 20 years (PP), high sugar ryegrass with white clover targeted at 30% coverage reseeded in 2013 (WC), and high sugar ryegrass reseeded in 2014 (HG). This study was conducted on the North Wyke Farm Platform (UK) from April 2017 to October 2017. Soil health indicators including soil organic carbon (SOC, measured by loss of ignition and elemental analyser), dissolved organic carbon (DOC), total nitrogen (TN), C:N ratio, soil C and N bulk isotopes, pH, bulk density (BD), aggregate stability, ergosterol concentration (as a proxy for fungi biomass), and earthworms (abundance, mass and density) were measured and analysed before and after application of dung and N fertilizer, urine and N fertiliser, and only N fertiliser. The highest SOC, TN, DOC, ergosterol concentration and earthworms as well as the lowest BD were found in PP, likely due to the lack of ploughing. Differences among treatments were observed due to the application of dung, resulting in an improvement in chemical indicators of soil health after 50 days of its application. Ergosterol concentration was significantly higher before treatment applications than at the end of the experiment. No changes were detected in BD and aggregate stability after treatment applications. We conclude that not enough time had passed for the soil to recover after the ploughing and reseeding of the permanent pasture, independently of the sward composition (HG or WC). Our results highlight the strong influence of the soil management legacy in temperate pasture and the positive effects of dung application on soil health over the short term. In addition, we point out the relevance of using standardised methods to report soil health indicators and some methodological limitations