18 research outputs found
The study of aqueous extract of Pterocarpus marsupium Roxb. on cytokine TNF-α in type 2 diabetic rats
Objective: This study was designed to investigate the effect of aqueous
extract of Pterocarpus marsupium Roxb. on elevated inflammatory
cytokine, tumor necrosis factor (TNF)-α in type 2 diabetic rats.
Materials and Methods: Type 2 diabetes was induced by administering
streptozotocin (90 mg/kg, i.p.) in a neonatal rat model. Aqueous
extract of P. marsupium at a dose of 100 and 200 mg/kg was given orally
to desired group of animals for a period of 4 weeks. After 4 weeks of
drug treatment, parameters such as fasting blood glucose, postprandial
blood glucose, and TNF-α in serum were analyzed. Results: Aqueous
extract of P. marsupium at both doses, i.e., 100 and 200 mg/kg,
decreased the fasting and postprandial blood glucose in type 2 diabetic
rats. The 200 mg/kg had more pronounced effect on postprandial
hyperglycemia. The drug also improved the body weight of diabetic
animals. Cytokine TNF-α was found to be elevated in untreated
diabetic rats due to chronic systemic inflammation. The aqueous extract
at both doses significantly (P < 0.001) decreased the elevated
TNF-α level in type 2 diabetic rats. Conclusion: Modulation of
cytokine TNF-α by the rasayana drug P. marsupium is related with
its potential anti-diabetic activity