Evolving uses of oral reverse transcriptase inhibitors in the HIV-1 epidemic: From treatment to prevention

The HIV epidemic continues unabated, with no highly effective vaccine and no cure. Each new infection has significant economic, social and human costs and prevention efforts are now as great a priority as global antiretroviral therapy (ART) scale up. Reverse transcriptase inhibitors, the first licensed class of ART, have been at the forefront of treatment and prevention of mother to child transmission over the past two decades. Now, their use in adult prevention is being

On a class of integrable systems with a quartic first integral

31 pages, no figureInternational audienceWe generalize, to some extent, the results on integrable geodesic flows on two dimensional manifolds with a quartic first integral in the framework laid down by Selivanova and Hadeler. The local structure is first determined by a direct integration of the differential system which expresses the conservation of the quartic observable and is seen to involve a finite number of parameters. The global structure is studied in some details and leads to a class of models living on the manifolds S^2, H^2 or R^2. As special cases we recover Kovalevskaya's integrable system and a generalization of it due to Goryachev