1,804 research outputs found
GHR transcript heterogeneity may explain the phenotypic variability in patients with homozygous GHR pseudoexon (6 Psi) mutation
Running the hypothesis of a bio molecular approach to psychiatric disorder characterization and fatty acids therapeutical choices
Aviation and climate change
We describe the current status of knowledge regarding the contribution of aviation to anthropogenic climate forcing. The emissions and associated radiative forcings from aviation are compared to those from other modes of transport. The different analytical metrics used to quantify climate forcing are presented showing their relevancies and uncertainties. The discussion then focuses on the use of radiative forcing, one of the most commonly used metric, in accounting for the climate change contribution from aviation with a particular look at how the contribution from CO2 and non-CO2 greenhouse gases can be compared.O. Dessens acknowledges funding from QUANTIFY (European Union 6th Framework Program under contract number 003893)
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Latitudinal variation of the effect of aviation NOx emissions on atmospheric ozone and methane and related climate metrics
We evaluate the response to regional and latitudinal changes in aircraft NOx emissions using several climate metrics (radiative forcing (RF), Global Warming Potential (GWP), Global Temperature change Potential (GTP)). Global chemistry transport model integrations were performed with sustained perturbations in regional aircraft and aircraft-like NOx emissions. The RF due to the resulting ozone and methane changes is then calculated. We investigate the impact of emission changes for specific geographical regions (approximating to USA, Europe, India and China) and cruise altitude emission changes in discrete latitude bands covering both hemispheres. We find that lower latitude emission changes (per Tg N) cause ozone and methane RFs that are about a factor of 6 larger than those from higher latitude emission changes. The net RF is positive for all experiments. The meridional extent of the RF is larger for low latitude emissions. GWPs for all emission changes are positive, with tropical emissions having the largest values; the sign of the GTP depends on the choice of time horizon.GR acknowledges funding through the EU FP6 QUANTIFY Project. MOK acknowledges funding from NERC through the AIM Project. KS acknowledges support from the EU FP7 ECLIPSE project
Macroscopic nucleation phenomena in continuum media with long-range interactions
Nucleation, commonly associated with discontinuous transformations between
metastable and stable phases, is crucial in fields as diverse as atmospheric
science and nanoscale electronics. Traditionally, it is considered a
microscopic process (at most nano-meter), implying the formation of a
microscopic nucleus of the stable phase. Here we show for the first time, that
considering long-range interactions mediated by elastic distortions, nucleation
can be a macroscopic process, with the size of the critical nucleus
proportional to the total system size. This provides a new concept of
"macroscopic barrier-crossing nucleation". We demonstrate the effect in
molecular dynamics simulations of a model spin-crossover system with two
molecular states of different sizes, causing elastic distortions.Comment: 12 pages, 4 figures. Supplementary information accompanies this paper
at http://www.nature.com/scientificreport
Whole-exome sequencing gives additional benefits compared to candidate gene sequencing in the molecular diagnosis of children with growth hormone or IGF-1 insensitivity
Ipsen UK!(HLS).
Sandoz Pharmaceutical
Luminescent properties of Bi-doped polycrystalline KAlCl4
We observed an intensive near-infrared luminescence in Bi-doped KAlCl4
polycrystalline material. Luminescence dependence on the excitation wavelength
and temperature of the sample was studied. Our experimental results allow
asserting that the luminescence peaked near 1 um belongs solely to Bi+ ion
which isomorphically substitutes potassium in the crystal. It was also
demonstrated that Bi+ luminescence features strongly depend on the local ion
surroundings
Successful treatment of fusarium solani ecthyma gangrenosum in a patient affected by leukocyte adhesion deficiency type 1 with granulocytes transfusions
<p>Abstract</p> <p>Background</p> <p>Ecthyma gangrenosum (EG) manifests as a skin lesion affecting patients suffering extreme neutropenia and is commonly associated with <it>Pseudomonas aeruginosa </it>in immunocompromised patients. Leukocyte adhesion deficiency I (LAD I) which count among primary immunodeficiency syndromes of the innate immunity, is an autosomal recessive disorder characterized in its severe phenotype by a complete defect in CD18 expression on neutrophils, delayed cord separation, chronic skin ulcers mainly due to recurrent bacterial and fungal infections, leucocytosis with high numbers of circulating neutrophils and an accumulation of abnormally low number of neutrophils at sites of infection.</p> <p>Case Presentation</p> <p>We report at our knowledge the first case of a child affected by LAD-1, who experienced during her disease course a multi-bacterial and fungal EG lesion caused by <it>fusarium solani</it>. Despite targeted antibiotics and anti-fungi therapy, the lesion extended for as long as 18 months and only massive granulocytes pockets transfusions in association with G-CSF had the capacity to cure this lesion.</p> <p>Conclusion</p> <p>We propose that granulocytes pockets transfusions will be beneficial to heal EG especially in severely immunocompromised patients.</p
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