1,973 research outputs found
Generalized Spring Tensor Model: A New Improved Load Balancing Method in Cloud Computing
Significant characteristics of cloud computing such as elasticity, scalability and payment model attract businesses to replace their legacy infrastructure with the newly offered cloud technologies. As the number of the cloud users is growing rapidly, extensive load volume will affect performance and operation of the cloud. Therefore, it is essential to develop smarter load management methods to ensure effective task scheduling and efficient management of resources. In order to reach these goals, varieties of algorithms have been explored and tested by many researchers. But so far, not many operational load balancing algorithms have been proposed that are capable of forecasting the future load patterns in cloud-based systems. The aim of this research is to design an effective load management tool, characterized by collective behavior of the workflow tasks and jobs that is able to predict various dynamic load patterns occurring in cloud networks. The results show that the proposed new load balancing algorithm can visualize the network load by projecting the existing relationships among submitted tasks and jobs. The visualization can be particularly useful in terms of monitoring the robustness and stability of the cloud systems. © Springer International Publishing Switzerland 2015
Hints of R-parity violation in B decays into
In this article we show that the recently observed enhanced semi-leptonic and
leptonic decay rates of the B meson into \tau \nu modes can be explained within
the frame work of R-parity violating (RPV) MSSM. In particular, RPV
contributions involving the exchange of right-handed down-type squarks give a
universal contribution to the B+ --> \tau \nu, B --> D \tau \nu and the B -->
D* \tau \nu decays. We find that the masses and couplings that explain the
enhanced B decay rates are phenomelogically viable and the squarks can possibly
be observed at the LHC.Comment: 8 pages and 3 figures; Updated section 2 and 3, but results are
unmodifie
A new CP violating observable for the LHC
We study a new type of CP violating observable that arises in three body
decays that are dominated by an intermediate resonance. If two interfering
diagrams exist with different orderings of final state particles, the required
CP-even phase arises due to the different virtualities of the resonance in each
of the two diagrams. This method can be an important tool for accessing new CP
phases at the LHC and future colliders.Comment: 22 pages, v2: discussion of charged particle decays and a few
references added v3: typos corrected, matches published versio
Long Lived Fourth Generation and the Higgs
A chiral fourth generation is a simple and well motivated extension of the
standard model, and has important consequences for Higgs phenomenology. Here we
consider a scenario where the fourth generation neutrinos are long lived and
have both a Dirac and Majorana mass term. Such neutrinos can be as light as 40
GeV and can be the dominant decay mode of the Higgs boson for Higgs masses
below the W-boson threshold. We study the effect of the Majorana mass term on
the Higgs branching fractions and reevaluate the Tevatron constraints on the
Higgs mass. We discuss the prospects for the LHC to detect the semi-invisible
Higgs decays into fourth generation neutrino pairs. Under the assumption that
the lightest fourth generation neutrino is stable, it's thermal relic density
can be up to 20% of the observed dark matter density in the universe. This is
in agreement with current constraints on the spin dependent neutrino-neutron
cross section, but can be probed by the next generation of dark matter direct
detection experiments.Comment: v1: 19 pages, 5 figures; v2: References added; v3: version to appear
in JHE
Dynamical R-parity Breaking at the LHC
In a class of extensions of the minimal supersymmetric standard model with
(B-L)/left-right symmetry that explains the neutrino masses, breaking R-parity
symmetry is an essential and dynamical requirement for successful gauge
symmetry breaking. Two consequences of these models are: (i) a new kind of
R-parity breaking interaction that protects proton stability but adds new
contributions to neutrinoless double beta decay and (ii) an upper bound on the
extra gauge and parity symmetry breaking scale which is within the large hadron
collider (LHC) energy range. We point out that an important prediction of such
theories is a potentially large mixing between the right-handed charged lepton
() and the superpartner of the right-handed gauge boson (), which leads to a brand new class of R-parity violating interactions of
type and \widetilde{d^c}^\dagger\u^c
e^c. We analyze the relevant constraints on the sparticle mass spectrum and
the LHC signatures for the case with smuon/stau NLSP and gravitino LSP. We note
the "smoking gun" signals for such models to be lepton flavor/number violating
processes: (or ) and
(or ) without
significant missing energy. The predicted multi-lepton final states and the
flavor structure make the model be distinguishable even in the early running of
the LHC.Comment: 30 pages, 13 figures, 6 tables, reference adde
Light neutralino dark matter in the MSSM and its implication for LHC searches for staus
It was shown in a previous study that a lightest neutralino with mass below
30 GeV was severely constrained in the minimal supersymmetric standard model
(MSSM), unless it annihilates via a light stau and thus yields the observed
dark matter abundance. In such a scenario, while the stau is the
next-to-lightest supersymmetric particle (NLSP), the charginos and the other
neutralinos as well as sleptons of the first two families are also likely to be
not too far above the mass bounds laid down by the Large Electron Positron
(LEP) collider. As the branching ratios of decays of the charginos and the
next-to-lightest neutralino into staus are rather large, one expects
significant rates of tau-rich final states in such a case. With this in view,
we investigate the same-sign ditau and tri-tau signals of this scenario at the
Large Hadron Collider (LHC) for two MSSM benchmark points corresponding to
light neutralino dark matter. The associated signal rates for these channels
are computed, for the centre-of-mass energy of 14 TeV. We find that both
channels lead to appreciable rates if the squarks and the gluino are not too
far above a TeV, thus allowing to probe scenarios with light neutralinos in the
14 TeV LHC run with 10-100 fb^{-1}.Comment: 19p, 4 Fig
Distinctions in gastric cancer gene expression signatures derived from laser capture microdissection versus histologic macrodissection
<p>Abstract</p> <p>Background</p> <p>Gastric cancer samples obtained by histologic macrodissection contain a relatively high stromal content that may significantly influence gene expression profiles. Differences between the gene expression signature derived from macrodissected gastric cancer samples and the signature obtained from isolated gastric cancer epithelial cells from the same biopsies using laser-capture microdissection (LCM) were evaluated for their potential experimental biases.</p> <p>Methods</p> <p>RNA was isolated from frozen tissue samples of gastric cancer biopsies from 20 patients using both histologic macrodissection and LCM techniques. RNA from LCM was subject to an additional round of T7 RNA amplification. Expression profiling was performed using Affymetrix HG-U133A arrays. Genes identified in the expression signatures from each tissue processing method were compared to the set of genes contained within chromosomal regions found to harbor copy number aberrations in the tumor samples by array CGH and to proteins previously identified as being overexpressed in gastric cancer.</p> <p>Results</p> <p>Genes shown to have increased copy number in gastric cancer were also found to be overexpressed in samples obtained by macrodissection (LS <it>P </it>value < 10<sup>-5</sup>), but not in array data generated using microdissection. A set of 58 previously identified genes overexpressed in gastric cancer was also enriched in the gene signature identified by macrodissection (LS <it>P </it>< 10<sup>-5</sup>), but not in the signature identified by microdissection (LS <it>P </it>= 0.013). In contrast, 66 genes previously reported to be underexpressed in gastric cancer were enriched in the gene signature identified by microdissection (LS <it>P </it>< 10<sup>-5</sup>), but not in the signature identified by macrodissection (LS <it>P </it>= 0.89).</p> <p>Conclusions</p> <p>The tumor sampling technique biases the microarray results. LCM may be a more sensitive collection and processing method for the identification of potential tumor suppressor gene candidates in gastric cancer using expression profiling.</p
Efficacy of weekly teriparatide does not vary by baseline fracture probability calculated using FRAX
Summary
The aim of this study was to determine the efficacy of once-weekly teriparatide as a function of baseline fracture risk. Treatment with once-weekly teriparatide was associated with a statistically significant 79 % decrease in vertebral fractures, and in the cohort as a whole, efficacy was not related to baseline fracture risk.
Introduction
Previous studies have suggested that the efficacy of some interventions may be greater in the segment of the population at highest fracture risk as assessed by the FRAX® algorithms. The aim of the present study was to determine whether the antifracture efficacy of weekly teriparatide was dependent on the magnitude of fracture risk.
Methods
Baseline fracture probabilities (using FRAX) were computed from the primary data of a phase 3 study (TOWER) of the effects of weekly teriparatide in 542 men and postmenopausal women with osteoporosis. The outcome variable comprised morphometric vertebral fractures. Interactions between fracture probability and efficacy were explored by Poisson regression.
Results
The 10-year probability of major osteoporotic fractures (without BMD) ranged from 7.2 to 42.2 %. FRAX-based hip fracture probabilities ranged from 0.9 to 29.3 %. Treatment with teriparatide was associated with a 79 % (95 % CI 52–91 %) decrease in vertebral fractures assessed by semiquantitative morphometry. Relative risk reductions for the effect of teriparatide on the fracture outcome did not change significantly across the range of fracture probabilities (p = 0.28). In a subgroup analysis of 346 (64 %) participants who had FRAX probabilities calculated with the inclusion of BMD, there was a small but significant interaction (p = 0.028) between efficacy and baseline fracture probability such that high fracture probabilities were associated with lower efficacy.
Conclusion
Weekly teriparatide significantly decreased the risk of morphometric vertebral fractures in men and postmenopausal women with osteoporosis. Overall, the efficacy of teriparatide was not dependent on the level of fracture risk assessed by FRAX in the cohort as a whole
Mixed Mediation of Supersymmetry Breaking with Anomalous U(1) Gauge Symmetry
Models with anomalous U(1) gauge symmetry contain various superfields which
can have nonzero supersymmetry breaking auxiliary components providing the
origin of soft terms in the visible sector, e.g. the U(1) vector superfield,
the modulus or dilaton superfield implementing the Green-Schwarz anomaly
cancellation mechanism, U(1)-charged but standard model singlet matter
superfield required to cancel the Fayet-Iliopoulos term, and finally the
supergravity multiplet. We examine the relative strength between these
supersymmetry breaking components in a simple class of models, and find that
various different mixed mediations of supersymmetry breaking, involving the
modulus, gauge, anomaly and D-term mediations, can be realized depending upon
the characteristics of D-flat directions and how those D-flat directions are
stabilized with a vanishing cosmological constant. We identify two parameters
which represent such properties and thus characterize how the various
mediations are mixed. We also discuss the moduli stabilization and soft terms
in a variant of KKLT scenario, in which the visible sector K\"ahler modulus is
stabilized by the D-term potential of anomalous U(1) gauge symmetry.Comment: 30 pages, 5 figure
Collider signatures of goldstini in gauge mediation
We investigate the collider signatures of the multiple goldstini scenario in
the framework of gauge mediation. This class of models is characterized by a
visible sector (e.g. the MSSM or any extension) coupled by gauge interactions
to more than one SUSY breaking sector. The spectrum consists of a light
gravitino LSP, behaving as a goldstino, and a number of neutral fermions (the
pseudo-goldstini) with a mass between that of the LSP and that of the lightest
particle of the observable sector (LOSP). We consider the two situations where
the LOSP is either a gaugino-like neutralino or a stau and we assume only one
pseudo-goldstino of a mass of O(100) GeV. The coupling of the LOSP to the
pseudo-goldstino can be enhanced with respect to those of the gravitino giving
rise to characteristic signatures. We show that the decay modes of the LOSP
into a SM particle and a pseudo-goldstino can be significant. For both LOSP
scenarios we analyze (pseudo)-goldstini production at colliders. Compared to
standard gauge mediation the final state spectrum is softer and more
structured.Comment: v2: analysis of the stau LOSP scenario added, sections rearranged,
and Introduction and Conclusions rewritten to include the added scenario.
Version to appear in JHE
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