80 research outputs found

    Atopic dermatitis-like disease in a rat model

    No full text
    The Atopic dermatitis (AD) is a most important topic in clinical dermatology. In fact, the pathogenesis of this chronic inflammatory skin disease, primarily characterized by pruritus and dry skin, is still far from being fully understood. To look further into this complex disease, male adult Wistar rats (n = 10) were used as a model where acetone (AA) acted as the active challenger in a 3-day treatment setting, and compared with water (AW). On day 3, one hour after the last treatment, the AA area exhibited higher transepidermal water loss (TEWL), capillary blood flow, and reduced hydration when compared to AW. The scratching behavior was markedly higher in the AA treated group (n = 5) than in the AW group (n = 5). These interesting results justify the application of this model as a clinical experimental tool for AD research
    corecore