2,823 research outputs found
Crystalline electric field effects in the electrical resistivity of PrOsSb
The temperature and magnetic field dependencies of the electrical
resistivity of the recently discovered heavy fermion superconductor
\PrOsSb{} have features that are associated with the splitting of the Pr
Hund's rule multiplet by the crystalline electric field (CEF). These features
are apparently due to magnetic exchange and aspherical Coulomb scattering from
the thermally populated CEF-split Pr energy levels. The data
in zero magnetic field can be described well by calculations based on CEF
theory for various ratios of magnetic exchange and aspherical Coulomb
scattering, and yield CEF parameters that are qualitatively consistent with
those previously derived from magnetic susceptibility, specific heat, and
inelastic neutron scattering measurements. Calculated isotherms for a
ground state qualitatively account for the `dome-shaped' feature
in the measured isotherms.Comment: 8 pages, 2 figures, submitted to Journal of Physics: Condensed Matte
Systematic review and meta-analysis of temozolomide in animal models of glioma:was clinical efficacy predicted?
Background:Malignant glioma is an aggressive tumour commonly associated with a dismal outcome despite optimal surgical and radio-chemotherapy. Since 2005 temozolomide has been established as first-line chemotherapy. We investigate the role of in vivo glioma models in predicting clinical efficacy.Methods:We searched three online databases to systematically identify publications testing temozolomide in animal models of glioma. Median survival and number of animals treated were extracted and quality was assessed using a 12-point scale; random effects meta-analysis was used to estimate efficacy. We analysed the impact of study design and quality and looked for evidence of publication bias.Results:We identified 60 publications using temozolomide in models of glioma, comprising 2443 animals. Temozolomide prolonged survival by a factor of 1.88 (95% CI 1.74-2.03) and reduced tumour volume by 50.4% (41.8-58.9) compared with untreated controls. Study design characteristics accounted for a significant proportion of between-study heterogeneity, and there was evidence of a significant publication bias.Conclusion:These data reflect those from clinical trials in that temozolomide improves survival and reduces tumour volume, even after accounting for publication bias. Experimental in vivo glioma studies of temozolomide differ from those of other glioma therapies in their consistent efficacy and successful translation into clinical medicine
The iron law of democratic socialism: British and Austrian influences on the young Karl Polanyi
This article has been made available through the Brunel Open Access Publishing Fund.A central thesis of Karl Polanyi's The great transformation concerns the tensions between capitalism and democracy: the former embodies the principle of inequality, while democracy represents that of equality. This paper explores the intellectual heritage of this thesis, in the ‘functional theory’ of G.D.H. Cole and Otto Bauer and in the writings of Eduard Bernstein. It scrutinizes Polanyi's relationship with Bernstein's ‘evolutionary socialism’ and charts his ‘double movement’ vis-à-vis Marxist philosophy: in the 1910s he reacted sharply against Marxism's deterministic excesses, but he then, in the 1920s, engaged in sympathetic dialogue with Austro-Marxist thinkers. The latter, like Bernstein, disavowed economic determinism and insisted upon the importance and autonomy of ethics. Yet they simultaneously predicted a law-like expansion of democracy from the political to the economic arena. Analysis of this contradiction provides the basis for a concluding discussion that reconsiders the deterministic threads in Polanyi's oeuvre. Whereas for some Polanyi scholars these attest to his residual attraction to Marxism, I argue that matters are more complex. While Polanyi did repudiate the more rigidly deterministic of currents in Marxist philosophy, those to which he was attracted, notably Bernstein's ‘revision’ and Austro-Marxism, incorporated a deterministic fatalism of their own, in respect of democratization. Herein lies a more convincing explanation of Polanyi's incomplete escape from a deterministic philosophy of history, as exemplified in his masterwork, The great transformation
Building governance and energy efficiency: Mapping the interdisciplinary challenge
Improving the energy efficiency of multi-owned properties (MoPs)—commonly known as apartment or condominium buildings—is central to the achievement of European energy targets. However, little work to date has focused on how to facilitate retrofit in this context. Drawing on interdisciplinary Social Sciences and Humanities expertise in academia, policy and practice, this chapter posits that decision-making processes within MoPs might provide a key to the retrofit challenge. Existing theories or models of decision-making, applied in the MoP context, might help to explain how collective retrofit decisions are taken—or overlooked. Insights from case studies and practitioners are also key. Theories of change might then be employed to develop strategies to facilitate positive retrofit decisions. The chapter maps the issues and sets an agenda for further interdisciplinary research in this novel area
International capital mobility in an era of globalisation: adding a political dimension to the 'Feldstein–Horioka Puzzle'
The debate about the scope of feasible policy-making in an era of globalisation continues to be set within the context of an assumption that national capital markets are now perfectly integrated at the international level. However, the empirical evidence on international capital mobility contradicts such an assumption. As a consequence, a significant puzzle remains. Why is it, in a world in which the observed pattern of capital flows is indicative of a far from globalised reality, that public policy continues to be constructed in line with more extreme variants of the globalisation hypothesis? I attempt to solve this puzzle by arguing that ideas about global capital market integration have an independent causal impact on political outcomes which extends beyond that which can be attributed to the extent of their actual integration
Multipolar Interactions in the Anderson Lattice with Orbital Degeneracy
Microscopic investigation is performed for intersite multipolar interactions
in the orbitally degenerate Anderson lattice, with CeB taken as an
exemplary target. In addition to the intermediate state,
Hund's-rule ground states are included as intermediate states for the
interactions. The conduction-band states are taken as plane waves and the
hybridization as spherically symmetric. The spatial dependences of multipolar
interactions are given by the relative weight of partial wave components along
the pair of sites. It is clarified how the the anisotropy arises in the
interactions depending on the orbital degeneracy and the spatial configuration.
The stability of the antiferro-quadrupole order in the phase II of
CeB is consistent with our model. Moreover, the pseudo-dipole interactions
follow a tendency required by the phenomenological model for the phase III.Comment: 30 pages, 4 figure
Role of the Hsp90 cochaperone, FKBPL, in oestrogen receptor signalling and breast cancer growth and survival
Crossover between Fermi Liquid and non-Fermi Liquid in Orbitally Degenerate Kondo Systems
Entanglement of spin and orbital Kondo effect is investigated on the basis of
a Kondo-type exchange model with twofold orbital degeneracy. By using Wilson's
numerical renormalization-group method, we examine dynamical and thermal
properties respecting the difference in time-reversal property of multipole
operators. In the presence of particle-hole symmetry, the model has a new
non-Fermi-liquid fixed point with a fractional entropy. The spectral intensity
of the quadrupole susceptibility diverges in the zero-frequency limit, while
the dipole susceptibility shows a Fermi-liquid-like behavior. This is
understood by mapping to the two-channel Kondo model, in which the dipole
moment is mapped onto the operators with the scaling dimension ,
while the quadrupole moment onto the operators with another scaling dimension
. Even for a fairly particle-hole asymmetric case with the
Fermi-liquid ground state, the non-Fermi-liquid behavior has significant
influences in electric and thermal properties.Comment: 7 pages, 9 figures, to appear in J. Phys Soc. Jpn. Vol. 68 No. 12,
title changed and some corrections mad
Physical education as Olympic education
Introduction
In a recent paper (Parry, 1998, p. 64), I argued that
the justification of PE activities lies in their capacity to facilitate the development of certain human excellences of a valued kind. Of course, the problem now lies in specifying those ‘human excellences of a valued kind’, and (for anyone) this task leads us into the area of philosophical anthropology.
I suggested that the way forward for Physical Education lies in the philosophical anthropology (and the ethical ideals) of Olympism, which provide a specification of a variety of human values and excellences which:
•have been attractive to human groups over an impressive span of time and space
•have contributed massively to our historically developed conceptions of ourselves
•have helped to develop a range of artistic and cultural conceptions that have defined Western culture.
•have produced a range of physical activities that have been found universally satisfying and challenging.
Although physical activities are widely considered to be pleasurable, their likelihood of gaining wide acceptance lies rather in their intrinsic value, which transcends the simply hedonic or relative good. Their ability to furnish us with pleasurable experiences depends upon our prior recognition in them of opportunities for the development and expression of valued human excellences. They are widely considered to be such opportunities for the expression of valued human excellences because, even when as local instantiations, their object is to challenge our common human propensities and abilities.
I claimed that Olympic ideals may be seen not merely as inert ‘ideals’, but living ideas which have the power to remake our notions of sport in education, seeing sport not as mere physical activity but as the cultural and developmental activity of an aspiring, achieving, well-balanced, educated and ethical individual.
This paper seeks to make good that claim by trying to develop a case for Physical Education as Olympic Education. I begin by setting out various accounts and conceptions of the Olympic Idea; then I suggest a unifying and organising account of the philosophical anthropology of Olympism; and this is followed by the practical application of that account in two examples of current ethical issues. Finally, I seek to present an account of Physical Education as Olympic Education
The arithmetic-geometric scaling spectrum for continued fractions
To compare continued fraction digits with the denominators of the
corresponding approximants we introduce the arithmetic-geometric scaling. We
will completely determine its multifractal spectrum by means of a number
theoretical free energy function and show that the Hausdorff dimension of sets
consisting of irrationals with the same scaling exponent coincides with the
Legendre transform of this free energy function. Furthermore, we identify the
asymptotic of the local behaviour of the spectrum at the right boundary point
and discuss a connection to the set of irrationals with continued fraction
digits exceeding a given number which tends to infinity.Comment: 22 pages, 1 figur
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