Eine bemerkenswerte Bio- und Lithofazies an der Basis des Unter-Hauterivium Nordwestdeutschlands

Im östlichen Teil des Niedersächsischen Beckens ist das Trans gressionskonglomerat des Unter-Hauterivium-Meeres ("Hilskon- glomerat") in Küsten- und Schwellennähe durch einen hohen, meist organogenen Karbonatgehalt (Biosparit), Biomikrit, Kalk und Mergelstein) sowie Brauneisengeröll- und Quarzsandführung gekennzeichnet. Gleichzeitig weisen diese Basisschichten des Unter-Hauterivium hier einen außergewöhnlichen Fauneninhalt auf ("Sonderfazies”), der im küstenferneren Bereich des östlichen wie auch im Gesamtbereich des mittleren und westlichen Niedersächsischen Beckens bisher nicht beobachtet werden konnte ("Normalfazies"). In der Mikrofauna erscheinen, z.T. im Faunenbild dominierend, Foraminiferen mediterraner Herkunft (Trocholina, Meandrospira Cyclammina u.a.). Auch die Megafauna der "Sonderfazies" ist durch Warm- und Flachwasserformen (Kalkschwämme, Korallen, Bryozoen, Serpuliden, Seelilien) charakterisiert. Da auch in der östlichen Fortsetzung des Norddeutsch-Polnischen Unterkreide-Meeres (Brandenburg, Mecklenburg) u.a. eben falls die Foraminiferen-Gattungen Trocholina und Cyclammina sowie Bryozoen und Seelilien beobachtet werden konnten und im Hauterivium lediglich über die südpolnische Meeresstraße eine Verbindung zum mediterranen Meeresraum bestand, müssen warme Meeresströmungen aus südöstlicher Richtung als Ursache für den Karbonatreichtum der Sedimente und deren Besiedelung durch benthische "Warmwasserformen" angenommen werden. Auch die Ammoniten-Gattung Endemoceras ist nach Untersuchungen von THIERMANN (1963) auf diesem Wege in das Niedersächsische Becken eingewandert. Da die Unterkreide-Transgression mit Konglomerat- und Aufarbeitungshorizonten in einigen küsten- und schwellennahen Bereichen des nordwestdeutschen Unterkreide-Meeres bereits im höheren Valanginium oder aber erst im höheren Unter-Hauteri- vium (z.B. Fallsteingebiet) bzw. tiefem Ober-Hauterivium (z.B. Westerberg b. Alfeld) erfolgte, ist das sog. "Hilskon- glomerat" i.w.S. nicht als synchrone Bildung anzusehen. Allerdings konnten der spezifische petrographische Charakter sowie die typische Fauaenvergesellschaftung der "Sonderfazies" bisher nur im Basiskonglomerat des Unter-Hauterivium und nur im östlichen Teil des Niedersächsischen Beckens beobachtet werden. Daraus ließe sich ableiten, daß nur für einen (im geologischen Maßstab!) enger begrenzten Zeitraum (tieferes Unter- Hauterivium) die zur Entstehung der "Sonderfazies" notwendigen hydrologischen und klimatischen Voraussetzungen gegeben waren. So nimmt der Karbonatgehalt der Sedimente bis zum Unter-Aptium deutlich ab; nur im höheren Ober-Hauterivium steigen die Karbonatgehalte wieder stärker an, um dann im Barremium und Unter- Aptium die im Durchschnitt geringsten Werte der borealen Unterkreide NW-Deutschlands zu erreichen. Erst im Ober-Aptium steigen die Karbonatgehalte wieder an, sinken im Unter-Albium deutlich ab und nehmen vom Mittel-Albium bis Cenomanium kontinuierlich zu. Parallel zum abnehmenden Karbonatgehalt der Sedimente verschwinden bereits im Hauterivium Korallen, Kalkschwämme und Bryozoen, im höchsten Ober-Hauterivium auch die Crinoiden. Erst im höheren Unter-Albium erscheinen wieder Crinoiden im Faunenbild der Bodentier-Vergesellschaftungen. Daraus läßt sich eine deutliche Temperaturabnahme - zumindest im Bodenwasserbereich - infolge fehlender warmer Meeres-Strömungen, verbunden mit einer Zunahme der Wassertiefe im Beckenbereich vom Unter-Barremium bis Unter-Aptium, ableiten. Nach beträchtlicher regionaler Ausweitung der Meeresräume während des Albium kennzeichnen abseits der Küsten- und Schwellenbereiche erstmalig pelagische Faziesverhältnisse das lithologische und faunistische Bild der höheren Unterkreide NW-Deutschlands

Radical innovations as supply chain disruptions? A paradox between change and stability

Supply chains withstand multiple tensions, some of which are paradoxical. Radical product and process innovations bring such tensions to the forefront by disrupting supply chains. Using two illustrations, this article considers the paradoxical tension between change and stability in upstream supply chains, which becomes particularly salient after radical innovation. Furthermore, the article discusses why and how paradox theory can help firms understand and manage this pressing tension between stability and change. This article then presents future research opportunities for using paradox theory to investigate other persistent post-innovation tensions in upstream supply chains. The aim of this article is to encourage new studies that develop responses to such paradoxical tensions, an area ripe for research

The C2-domain protein QUIRKY and the receptor-like kinase STRUBBELIG localize to plasmodesmata and mediate tissue morphogenesis in Arabidopsis thaliana

Tissue morphogenesis in plants requires communication between cells, a process involving the trafficking of molecules through plasmodesmata (PD). PD conductivity is regulated by endogenous and exogenous signals. However, the underlying signaling mechanisms remain enigmatic. In Arabidopsis, signal transduction mediated by the receptor-like kinase STRUBBELIG (SUB) contributes to inter-cell layer signaling during tissue morphogenesis. Previous analysis has revealed that SUB acts non-cell-autonomously suggesting that SUB controls tissue morphogenesis by participating in the formation or propagation of a downstream mobile signal. A genetic screen identified QUIRKY (QKY), encoding a predicted membrane-anchored C2-domain protein, as a component of SUB signaling. Here, we provide further insight into the role of QKY in this process. We show that like SUB, QKY exhibits non-cell-autonomy when expressed in a tissue-specific manner and that non-autonomy of QKY extends across several cells. In addition, we report on localization studies indicating that QKY and SUB localize to PD but independently of each other. FRET-FLIM analysis suggests that SUB and QKY are in close contact at PD in vivo. We propose a model where SUB and QKY interact at PD to promote tissue morphogenesis, thereby linking RLK-dependent signal transduction and intercellular communication mediated by PD

Optical amplification and stability of spiroquaterphenyl compounds and blends

In this contribution, we present a systematic investigation on a series of spiroquaterphenyl compounds optimised for solid state lasing in the near ultraviolet (UV). Amplified spontaneous emission (ASE) thresholds in the order of 1 μJ/cm^2 are obtained in neat (undiluted) films and blends, with emission peaks at 390±1 nm for unsubstituted and meta-substituted quaterphenyls and 400±4 nm for para-ether substituted quaterphenyls. Mixing with a transparent matrix retains a low threshold, shifts the emission to lower wavelengths and allows a better access to modes having their intensity maximum deeper in the film. Chemical design and blending allow an independent tuning of optical and processing properties such as the glass transition

Observation of geometric phases in quantum erasers

We introduce a simple experiment involving a double-slit interferometer by which one can learn basic concepts of quantum interference such as which-path marking, quantum erasers, and geometric phases. Each of them exhibits seemingly mysterious phenomena in quantum physics. In our experiment, we use the double-slit interference of visible light with the polarization as an internal state to demonstrate the disappearance of fringes by which-path marking, recovery of interference using quantum erasers, and the rapid shifting of the fringe pattern induced by the geometric phase. We also present a simple theoretical analysis of an interferometer with an internal state.Comment: 7 pages, 14 figure

DNA Resection at Chromosome Breaks Promotes Genome Stability by Constraining Non-Allelic Homologous Recombination

DNA double-strand breaks impact genome stability by triggering many of the large-scale genome rearrangements associated with evolution and cancer. One of the first steps in repairing this damage is 5′→3′ resection beginning at the break site. Recently, tools have become available to study the consequences of not extensively resecting double-strand breaks. Here we examine the role of Sgs1- and Exo1-dependent resection on genome stability using a non-selective assay that we previously developed using diploid yeast. We find that Saccharomyces cerevisiae lacking Sgs1 and Exo1 retains a very efficient repair process that is highly mutagenic to genome structure. Specifically, 51% of cells lacking Sgs1 and Exo1 repair a double-strand break using repetitive sequences 12–48 kb distal from the initial break site, thereby generating a genome rearrangement. These Sgs1- and Exo1-independent rearrangements depend partially upon a Rad51-mediated homologous recombination pathway. Furthermore, without resection a robust cell cycle arrest is not activated, allowing a cell with a single double-strand break to divide before repair, potentially yielding multiple progeny each with a different rearrangement. This profusion of rearranged genomes suggests that cells tolerate any dangers associated with extensive resection to inhibit mutagenic pathways such as break-distal recombination. The activation of break-distal recipient repeats and amplification of broken chromosomes when resection is limited raise the possibility that genome regions that are difficult to resect may be hotspots for rearrangements. These results may also explain why mutations in resection machinery are associated with cancer

Well-width dependence of exciton-phonon scattering in InxGa1 - xAs/GaAs single quantum wells

The temperature and density dependencies of the exciton dephasing time in In0.18Ga0.82As/GaAs single quantum wells with different thicknesses have been measured by degenerate four-wave mixing. The exciton-phonon scattering contribution to the dephasing is isolated by extrapolating the dephasing rate to zero-exciton density. From the temperature dependence of this rate we have deduced the linewidth broadening coefficients for acoustic and optical phonons. We find acoustic-phonon coefficients that increase from 1.6 to 3 μeV/K when increasing the well width from 1 to 4 nm. This is in quantitative agreement with theoretical predictions when the spatial extension of the exciton wave function, strongly penetrating into the GaAs barrier in thin InxGa1-xAs quantum wells, is taken into account. The optical-phonon coefficient does not show a systematic dependence on well thickness, and is comparable with the value for bulk GaAs

Spider Silk Constructs Enhance Axonal Regeneration and Remyelination in Long Nerve Defects in Sheep

BACKGROUND: Surgical reapposition of peripheral nerve results in some axonal regeneration and functional recovery, but the clinical outcome in long distance nerve defects is disappointing and research continues to utilize further interventional approaches to optimize functional recovery. We describe the use of nerve constructs consisting of decellularized vein grafts filled with spider silk fibers as a guiding material to bridge a 6.0 cm tibial nerve defect in adult sheep. METHODOLOGY/PRINCIPAL FINDINGS: The nerve constructs were compared to autologous nerve grafts. Regeneration was evaluated for clinical, electrophysiological and histological outcome. Electrophysiological recordings were obtained at 6 months and 10 months post surgery in each group. Ten months later, the nerves were removed and prepared for immunostaining, electrophysiological and electron microscopy. Immunostaining for sodium channel (NaV 1.6) was used to define nodes of Ranvier on regenerated axons in combination with anti-S100 and neurofilament. Anti-S100 was used to identify Schwann cells. Axons regenerated through the constructs and were myelinated indicating migration of Schwann cells into the constructs. Nodes of Ranvier between myelin segments were observed and identified by intense sodium channel (NaV 1.6) staining on the regenerated axons. There was no significant difference in electrophysiological results between control autologous experimental and construct implantation indicating that our construct are an effective alternative to autologous nerve transplantation. CONCLUSIONS/SIGNIFICANCE: This study demonstrates that spider silk enhances Schwann cell migration, axonal regrowth and remyelination including electrophysiological recovery in a long-distance peripheral nerve gap model resulting in functional recovery. This improvement in nerve regeneration could have significant clinical implications for reconstructive nerve surgery