84 research outputs found

    Structural studies of T4S systems by electron microscopy

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    Abstract: Type IV secretion (T4S) systems are large dynamic nanomachines that transport DNA and/or proteins through the membranes of bacteria. Analysis of T4S system architecture is an extremely challenging task taking into account their multi protein organisation and lack of overall global symmetry. Nonetheless the last decade demonstrated an amazing progress achieved by X-ray crystallography and cryo-electron microscopy. In this review we present a structural analysis of this dynamic complex based on recent advances in biochemical, biophysical and structural studies

    ICAR: endoscopic skull‐base surgery

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    Spezielle Dosierung bei Kindern — erfolgreiche kurze Kombinationsbehandlung zur Elimination der Hemmkörper auf Dauer

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    Factor VIII Inhibitor Treatment with High Doses of Factor VIII

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    Controlled, cross‐sectional MRI

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