Reviewing quality of governance:New perspectives and future research

In the concluding chapter, the editors address the central topics of the book as well as some lessons learnt on quality of governance. Public values do matter, but how do they relate (and conflict), with many actors involved in public governance, including at street level and in public-private networks? A broad panorama of values appears to be important for the quality of governance, but the interpretation of the values differs and context is always relevant (macro, meso, and micro). Thus, the work in progress and the chapter define an agenda for future research and offers food for thought for all levels of governance

Astrocytes: biology and pathology

Astrocytes are specialized glial cells that outnumber neurons by over fivefold. They contiguously tile the entire central nervous system (CNS) and exert many essential complex functions in the healthy CNS. Astrocytes respond to all forms of CNS insults through a process referred to as reactive astrogliosis, which has become a pathological hallmark of CNS structural lesions. Substantial progress has been made recently in determining functions and mechanisms of reactive astrogliosis and in identifying roles of astrocytes in CNS disorders and pathologies. A vast molecular arsenal at the disposal of reactive astrocytes is being defined. Transgenic mouse models are dissecting specific aspects of reactive astrocytosis and glial scar formation in vivo. Astrocyte involvement in specific clinicopathological entities is being defined. It is now clear that reactive astrogliosis is not a simple all-or-none phenomenon but is a finely gradated continuum of changes that occur in context-dependent manners regulated by specific signaling events. These changes range from reversible alterations in gene expression and cell hypertrophy with preservation of cellular domains and tissue structure, to long-lasting scar formation with rearrangement of tissue structure. Increasing evidence points towards the potential of reactive astrogliosis to play either primary or contributing roles in CNS disorders via loss of normal astrocyte functions or gain of abnormal effects. This article reviews (1) astrocyte functions in healthy CNS, (2) mechanisms and functions of reactive astrogliosis and glial scar formation, and (3) ways in which reactive astrocytes may cause or contribute to specific CNS disorders and lesions

Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice

Bisphenol A (BPA) is a man-made compound used to make polycarbonate plastics and epoxy resins; public health concerns have been fueled by findings that BPA exposure can reduce sex differences in brain and some behaviors. We asked if a low BPA dose, within the range measured in humans, ingested during pregnancy, would affect social behaviors in prepubertal mice. We noted sex differences in social interactions whereby females spent more time sitting side-by-side, while males engaged in more exploring and sitting alone. In addition BPA increased display of nose-to-nose contacts, play solicitations and approaches in both sexes. Interactions between sex and diet were found for self grooming, social interactions while sitting side-by-side and following the other mouse. In all these cases interactions were produced by differences between control and BPA females. We examined brains from embryos during late gestation to determine if gene expression differences might be correlated with some of the sexually dimorphic or BPA affected behaviors we observed. Because BPA treatments ended at birth we took the brains during embryogenesis to increase the probability of discovering BPA mediated effects. We also selected this embryonic age (E18.5) because it coincides with the onset of sexual differentiation of the brain. Interestingly, mRNA for the glutamate transporter, Slc1a1, was enhanced by exposure to BPA in female brains. Also we noted that BPA changed the expression of two of the three DNA methyltransferase genes, Dnmt1 and Dnmt3a. We propose that BPA affects DNA methylation of Sc1a1 during neural development. Sex differences in juvenile social interactions are affected by BPA and in particular this compound modifies behavior in females

Effects of Recipient Information and Urgency Cues on Phishing Detection

Phishing causes significant economic damage and erodes consumer trust in business communication. To better filter phishing emails, researchers have paid a substantial amount of attention to the characteristics of phishing emails. This study focused on the effects of recipient information and urgency cues on phishing detection. A total of 518 participants performed role-playing tasks in which they needed to discriminate legitimate emails and phishing emails. The results showed that the main effects of urgency cues and recipient information were significant. Under the condition of time constraints, the likelihood of replying to the phishing emails increased, and the likelihood of searching for the relevant information decreased. When recipient information was added to the phishing emails, the likelihood of replying to the phishing emails decreased, and the likelihood of deleting the phishing emails and searching the for relevant information increased. Meanwhile, the interaction effect of recipient information and time pressure was also significant. When recipient information was added to the phishing emails, the urgency cues had a significant negative effect on the detection behaviors. Under the condition of time constraints and recipient information addition, the likelihood of replying to the phishing emails increased, and the likelihood of deleting the phishing emails and searching for the relevant information decreased. These findings showed that phishing email characteristics strongly affect phishing susceptibility. A sense of urgency resulted in stress and impulsive behavior, and thus, the participants preferred quickly respond and perform less research. By exploring the mechanism underlying phishing processing, this study deepens the understanding of detecting deception and motivates more effective strategies or assistance systems to protect individuals from online fraud.</p