Exploratory assessment of left ventricular strain-volume loops in severe aortic valve diseases.

Objectives The purpose of this study was to examine left ventricular (LV) strain (ԑ)-volume loops to provide novel insight into the haemodynamic cardiac consequences of aortic valve stenosis (AS) and aortic valve regurgitation (AR). Methods 27 participants were retrospectively recruited: AR (n = 7), AS (n = 10) and controls (n = 10). Standard transthoracic echocardiography was utilised to obtain apical 4 chamber images to construct ԑ-volume relationships were assessed by: Early systolic ԑ (ԑ_ES), slope of ԑ-volume relation during systole (Sslope), End-systolic peak ԑ (peak ԑ), Diastolic uncoupling (systolic ԑ-diastolic ԑ at same volume) during early diastole (UNCOUP_ED) and late diastole (UNCOUP_LD). ROC-curves were used to determine the ability to detect impaired LV function. Results Whilst LV ejection fraction was comparable between groups, longitudinal peak ԑ was similarly reduced compared to controls. In contrast, ԑ_ES and Sslope were lower in both pathologies compared to controls (P  0.05) to distinguish AS vs Controls, AR vs Controls and AS vs AR, respectively. Conclusions Temporal changes in ԑ-volume characteristics provide novel insight into the haemodynamic cardiac impact of AS and AR. Contrary to traditional measures (i.e. ejection fraction, peak ԑ), these novel measures successfully distinguish between the haemodynamic cardiac impact of AS and AR. This article is protected by copyright. All rights reserved

Effects of preload manipulation on right ventricular contractility: invasive pressure-area loop versus non-invasive strain-area loop.

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The Acute Impact of Changes to Haemodynamic Load on the Left Ventricular Strain-Volume Relationship in Young and Older Men.

OBJECTIVES: Chronic changes in left ventricular (LV) haemodynamics, for example induced by increased afterload (i.e., hypertension), mediate changes in LV function. This study examined the proof-of-concept that: 1. the LV longitudinal strain (ԑ)-volume loop is sensitive to detect an acute increase in afterload, and 2. these effects differ between healthy young versus older men. METHODS: Thirty-five healthy male volunteers were recruited including 19 young (24±2 yr) and 16 older participants (67±5 yr). Tests were performed prior to, during and after 10-min recovery from acute manipulation of afterload. Real-time haemodynamic data was obtained and LV longitudinal ԑ-volume loops were calculated from 4-chamber images using 2D-echocardiography. RESULTS: Inflation of the anti-G-suit resulted in an immediate increase in heart rate, blood pressure and systemic vascular resistance, and a decrease in stroke volume (all P0.05). Manipulation of cardiac haemodynamics caused comparable effects in young versus older men (all P>0.05). CONCLUSIONS: Acute increases in afterload immediately change the diastolic phase of the LV longitudinal ԑ-volume loop in young and older men. This supports the potency of the LV longitudinal ԑ-volume loop to provide novel insights into dynamic cardiac function in humans in vivo

5-Year prognostic value of the right ventricular strain-area loop in patients with pulmonary hypertension.

AIMS: Patients with pre-capillary pulmonary hypertension (PH) show poor survival, often related to right ventricular (RV) dysfunction. In this study, we assessed the 5-year prognostic value of a novel echocardiographic measure that examines RV function through the temporal relation between RV strain (ϵ) and area (i.e. RV ϵ-area loop) for all-cause mortality in PH patients. METHODS AND RESULTS: Echocardiographic assessments were performed in 143 PH patients (confirmed by right heart catheterization). Transthoracic echocardiography was utilized to assess RV ϵ-area loop. Using receiver operating characteristic curve-derived cut-off values, we stratified patients in low- vs. high-risk groups for all-cause mortality. Kaplan-Meier survival curves and uni-/multivariable cox-regression models were used to assess RV ϵ-area loop's prognostic value (independent of established predictors: age, sex, N-terminal pro B-type natriuretic peptide, 6-min walking distance). During follow-up 45 (31%) patients died, who demonstrated lower systolic slope, peak ϵ, and late diastolic slope (all P < 0.05) at baseline. Univariate cox-regression analyses identified early systolic slope, systolic slope, peak ϵ, early diastolic uncoupling, and early/late diastolic slope to predict all-cause mortality (all P < 0.05), whilst peak ϵ possessed independent prognostic value (P < 0.05). High RV loop-score (i.e. based on number of abnormal characteristics) showed poorer survival compared to low RV loop-score (Kaplan-Meier: P < 0.01). RV loop-score improved risk stratification in high-risk patients when added to established predictors. CONCLUSION: Our data demonstrate the potential for RV ϵ-area loops to independently predict all-cause mortality in patients with pre-capillary PH. The non-invasive nature and simplicity of measuring the RV ϵ-area loop, support the potential clinical relevance of (repeated) echocardiography assessment of PH patients

Exercise Training Induces Left- but not Right-sided Cardiac Remodelling in Olympic Rowers

Whilst the athlete’s heart has been extensively described, less work has focused on the potential for elite athletes to demonstrate further cardiac remodelling upon an increase in training volume. Moreover, little work explored potential side-specific cardiac remodelling. Therefore, we examined the impact of an increase in training volume across 9-months in elite rowers on left- and right-sided cardiac structure, function and mechanics (i. e. longitudinal, radial and circumferential strain, twist and strain-volume loops). As part of the preparations to the 2012 Olympic Games, twenty-seven elite rowers (26.4±3.7years, 19 male) underwent echocardiography prior to and post (9 months) an increase in training volume (24 to 30–35 h weekly). Training increased left ventricular structure, including wall thickness, diameter, volume, mass and LV twist (all p0.05). The 9-month intervention showed no change in right ventricular/atrial structure, function or mechanics (all p>0.05). In conclusion, our data revealed that 9-month increased training volume in elite rowers induced left-sided (but not right-sided) structural remodelling, concomitant with an increase in left ventricular twist, with some changes larger in women