Chemical transport across the ITCZ in the central Pacific during an El Niño-Southern Oscillation cold phase event in March-April 1999

We examine interhemispheric transport processes that occurred over the central Pacific during the PEM-Tropics B mission (PTB) in March-April 1999 by correlating the observed distribution of chemical tracers with the prevailing and anomalous windfields. The Intertropical Convergence Zone (ITCZ) had a double structure during PTB, and interhemispheric mixing occurred in the equatorial region between ITCZ branches. The anomalously strong tropical easterly surface wind had a large northerly component across the equator in the central Pacific, causing transport of aged, polluted air into the Southern Hemisphere (SH) at altitudes below 4 km. Elevated concentrations of chemical tracers from the Northern Hemisphere (NH) measured south of the equator in the central Pacific during PTB may represent an upper limit because the coincidence of seasonal and cold phase ENSO conditions are optimum for this transport. Stronger and more consistent surface convergence between the northeasterly and southeasterly trade winds in the Southern Hemisphere (SH) resulted in more total convective activity in the SH branch of the ITCZ, at about 6° S. The middle troposphere between 4-7 km was a complex shear zone between prevailing northeasterly winds at low altitudes and southwesterly winds at higher altitudes. Persistent anomalous streamline patterns and the chemical tracer distribution show that during PTB most transport in the central Pacific was from SH to NH across the equator in the upper troposphere. Seasonal differences in source strength caused larger interhemispheric gradients of chemical tracers during PTB than during the complementary PEM-Tropics A mission in September-October 1996. Copyright 2001 by the American Geophysical Union

A meteorological overview of the Pacific Exploratory Mission (PEM) Tropics period

NASA's Pacific Exploratory Mission-Tropics (PEM-T) experiment investigated the atmospheric chemistry of a large portion of the tropical and subtropical Pacific Basin during August to October 1996. This paper summarizes meteorological conditions over the PEM-T domain. Mean flow patterns during PEM-T are described. Important circulation systems near the surface include subtropical anticyclones, the South Pacific Convergence Zone (SPCZ), the Intertropical Convergence Zone (ITCZ), and middle latitude transient cyclones. The SPCZ and ITCZ are areas of widespread ascent and deep convection; however, there is relatively little lightning in these oceanic regions. A large area of subsidence is associated with the subtropical anticyclone centered near Easter Island. PEM-T occurred during a period of near normal sea surface temperatures. When compared to an 11 year climatology (1986-1996), relatively minor circulation anomalies are observed during PEM-T. Some of these circulation anomalies are consistent with much stronger anomalies observed during previous La Nina events. In general, however, the 1996 PEM-T period appears to be climatologically representative. Meteorological conditions for specific flights from each major operations area are summarized. The vertical distribution of ozone along selected DC-8 flights is described using the DIAL remote sensing system. These ozone distributions are related to thermodynamic soundings obtained during aircraft maneuvers and to backward trajectories that arrived at locations along the flight tracks. Most locations in the deep tropics are found to have relatively small values of tropospheric ozone. Backward trajectories calculated from global gridded analyses show that much of this air originates from the east and has not passed over land within 10 days. The deep convection associated with the ITCZ and SPCZ also influences the atmospheric chemistry of these regions. Flights over portions of the subtropics and middle latitudes document layers of greatly enhanced tropospheric ozone, sometimes exceeding 80 ppbv. In situ carbon monoxide in these layers often exceeds 90 ppbv. These regions are located near, and especially south of Tahiti, Easter Island, and Fiji. The layers of enhanced ozone usually correspond to layers of dry air, associated with widespread subsiding air. The backward trajectories show that air parcels arriving in these regions originate from the west, passing over Australia and even extending back to southern Africa. These are regions of biomass burning. The in situ chemical measurements support the trajectory-derived origins of these ozone plumes. Thus the enhanced tropospheric ozone over the central Pacific Basin may be due to biomass burning many thousands of kilometers away. Middle-latitude portions of the PEM-T area are influenced by transient cyclones, and the DC-8 traversed tropopause folds during several flights. The flight area just west of Ecuador experiences outflow from South America. Thus the biomass burning that is prevalent over portions of Brazil influences this area. Copyright 1999 by the American Geophysical Union

Chemical characteristics of Pacific tropospheric air in the region of the Intertropical Convergence Zone and South Pacific Convergence Zone

The Pacific Exploratory Mission (PEM)-Tropics provided extensive aircraft data to study the atmospheric chemistry of tropospheric air in Pacific Ocean regions, extending from Hawaii to New Zealand and from Fiji to east of Easter Island. This region, especially the tropics, includes some of the cleanest tropospheric air of the world and, as such, is important for studying atmospheric chemical budgets and cycles. The region also provides a sensitive indicator of the global-scale impact of human activity on the chemistry of the troposphere, and includes such important features as the Pacific "warm pool," the Intertropical Convergence Zone (ITCZ), the South Pacific Convergence Zone (SPCZ), and Walker Cell circulations. PEM-Tropics was conducted from August to October 1996. The ITCZ and SPCZ are major upwelling regions within the South Pacific and, as such, create boundaries to exchange of tropospheric air between regions to the north and south. Chemical data obtained in the near vicinity of the ITCZ and the SPCZ are examined. Data measured within the convergent zones themselves are not considered. The analyses show that air north and south of the convergent zones have different chemical signatures, and the signatures are reflective of the source regions and transport histories of the air. Air north of the ITCZ shows a modest urban/industrialized signature compared to air south of the ITCZ. The chemical signature of air south of the SPCZ is dominated by combustion emissions from biomass burning, while air north of the SPCZ is relatively clean and of similar composition to ITCZ south air. Chemical signature differences of air north and south of the zones are most pronounced at altitudes below 5 km, and, as such, show that the ITCZ and SPCZ are effective low-altitude barriers to the transport of tropospheric air. At altitudes of 8 to 10 km, chemical signatures are less dissimilar, and air backward trajectories (to 10 days) show cross-convergent-zone flow. At altitudes below about 5 km, little cross-zonal flow is observed. Chemical signatures presented include over 30 trace chemical species including ultrafine, fine, and heated-fine (250°C) aerosol. Copyright 1999 by the American Geophysical Union

Reading In-Between the Lines: An Analysis of Dissenter

Efforts by content creators and social networks to enforce legal and policy-based norms, e.g. blocking hate speech and users, has driven the rise of unrestricted communication platforms. One such recent effort is Dissenter, a browser and web application that provides a conversational overlay for any web page. These conversations hide in plain sight - users of Dissenter can see and participate in this conversation, whereas visitors using other browsers are oblivious to their existence. Further, the website and content owners have no power over the conversation as it resides in an overlay outside their control. In this work, we obtain a history of Dissenter comments, users, and the websites being discussed, from the initial release of Dissenter in Feb. 2019 through Apr. 2020 (14 months). Our corpus consists of approximately 1.68M comments made by 101k users commenting on 588k distinct URLs. We first analyze macro characteristics of the network, including the user-base, comment distribution, and growth. We then use toxicity dictionaries, Perspective API, and a Natural Language Processing model to understand the nature of the comments and measure the propensity of particular websites and content to elicit hateful and offensive Dissenter comments. Using curated rankings of media bias, we examine the conditional probability of hateful comments given left and right-leaning content. Finally, we study Dissenter as a social network, and identify a core group of users with high comment toxicity.Comment: Accepted at IMC 202

Large-scale air mass characteristics observed over the remote tropical Pacific Ocean during March-April 1999: Results from PEM-Tropics B field experiment

Eighteen long-range flights over the Pacific Ocean between 38° S to 20° N and 166° E to 90° W were made by the NASA DC-8 aircraft during the NASA Pacific Exploratory Mission (PEM) Tropics B conducted from March 6 to April 18, 1999. Two lidar systems were flown on the DC-8 to remotely measure vertical profiles of ozone (O3), water vapor (H2O), aerosols, and clouds from near the surface to the upper troposphere along their flight track. In situ measurements of a wide range of gases and aerosols were made on the DC-8 for comprehensive characterization of the air and for correlation with the lidar remote measurements. The transition from northeasterly flow of Northern Hemispheric (NH) air on the northern side of the Intertropical Convergence Zone (ITCZ) to generally easterly flow of Southern Hemispheric (SH) air south of the ITCZ was accompanied by a significant decrease in O3, carbon monoxide, hydrocarbons, and aerosols and an increase in H2O. Trajectory analyses indicate that air north of the ITCZ came from Asia and/or the United States, while the air south of the ITCZ had a long residence time over the Pacific, perhaps originating over South America several weeks earlier. Air south of the South Pacific Convergence Zone (SPCZ) came rapidly from the west originating over Australia or Africa. This air had enhanced O3 and aerosols and an associated decrease in H2O. Average latitudinal and longitudinal distributions of O3 and H2O were constructed from the remote and in situ O3 and H2O data, and these distributions are compared with results from PEM-Tropics A conducted in August-October 1996. During PEM-Tropics B, low O3 air was found in the SH across the entire Pacific Basin at low latitudes. This was in strong contrast to the photochemically enhanced O3 levels found across the central and eastern Pacific low latitudes during PEM-Tropics A. Nine air mass types were identified for PEM-Tropics B based on their O3, aerosols, clouds, and potential vorticity characteristics. The data from each flight were binned by altitude according to air mass type, and these results showed the relative observational frequency of the different air masses as a function of altitude in seven regions over the Pacific. The average chemical composition of the major air mass types was determined from in situ measurements in the NH and SH, and these results provided insight into the origin, lifetime, and chemistry of the air in these regions. Copyright 2001 by the American Geophysical Union

Renal impairment in a rural African antiretroviral programme

Background: There is little knowledge regarding the prevalence and nature of renal impairment in African populations initiating antiretroviral treatment, nor evidence to inform the most cost effective methods of screening for renal impairment. With the increasing availability of the potentially nephrotixic drug, tenofovir, such information is important for the planning of antiretroviral programmes Methods: (i) Retrospective review of the prevalence and risk factors for impaired renal function in 2189 individuals initiating antiretroviral treatment in a rural African setting between 2004 and 2007 (ii) A prospective study of 149 consecutive patients initiating antiretrovirals to assess the utility of urine analysis for the detection of impaired renal function. Severe renal and moderately impaired renal function were defined as an estimated GFR of ≤ 30 mls/min/1.73 m2 and 30–60 mls/min/1.73 m2 respectively. Logistic regression was used to determine odds ratio (OR) of significantly impaired renal function (combining severe and moderate impairment). Co-variates for analysis were age, sex and CD4 count at initiation. Results: (i) There was a low prevalence of severe renal impairment (29/2189, 1.3% 95% C.I. 0.8–1.8) whereas moderate renal impairment was more frequent (287/2189, 13.1% 95% C.I. 11.6–14.5) with many patients having advanced immunosuppression at treatment initiation (median CD4 120 cells/μl). In multivariable logistic regression age over 40 (aOR 4.65, 95% C.I. 3.54–6.1), male gender (aOR 1.89, 95% C.I. 1.39–2.56) and CD4<100 cells/ul (aOR 1.4, 95% C.I. 1.07–1.82) were associated with risk of significant renal impairment (ii) In 149 consecutive patients, urine analysis had poor sensitivity and specificity for detecting impaired renal function. Conclusion: In this rural African setting, significant renal impairment is uncommon in patients initiating antiretrovirals. Urine analysis alone may be inadequate for identification of those with impaired renal function where resources for biochemistry are limited

Spatiotemporally localized solitons in resonantly absorbing Bragg reflectors

We predict the existence of spatiotemporal solitons (``light bullets'') in two-dimensional self-induced transparency media embedded in a Bragg grating. The "bullets" are found in an approximate analytical form, their stability being confirmed by direct simulations. These findings suggest new possibilities for signal transmission control and self-trapping of light.Comment: RevTex, 3 pages, 2 figures, to be published in PR

Spatiotemporally Localized Multidimensional Solitons in Self-Induced Transparency Media

"Light bullets" are multi-dimensional solitons which are localized in both space and time. We show that such solitons exist in two- and three-dimensional self-induced-transparency media and that they are fully stable. Our approximate analytical calculation, backed and verified by direct numerical simulations, yields the multi-dimensional generalization of the one-dimensional Sine-Gordon soliton.Comment: 4 pages, 4 figures, to appear in Phys. Rev. Let

Circulating Angiogenic Factors Associated with Response and Survival in Patients with Acute Graft-versus-Host Disease: Results from Blood and Marrow Transplant Clinical Trials Network 0302 and 0802

AbstractCirculating angiogenic factors (AF) reflect tissue healing capacity, although some AF can also contribute to inflammation and are indicative of endothelial dysfunction. The AF milieu in acute graft-versus-host disease (aGVHD) has not been broadly characterized. We hypothesized that patients with abundant AF involved in repair/regeneration versus those mediating damage/inflammation would have improved outcomes. Circulating AF known predominantly for repair/regeneration (epidermal growth factor [EGF], fibroblast growth factor-1 and -2, heparin binding–EGF–like growth factor, and vascular endothelial growth factor-A [VEGF-A], -C, and -D) and for damage/inflammation (angiopoietin-2, endothelin-1, soluble endoglin [sEng], follistatin [FS], leptin, and placental growth factor [PlGF]) were measured in a discovery set of hematopoietic cell recipients with grade III and IV aGVHD and compared with controls, then validated in 2 aGVHD cohorts enrolled in Blood and Marrow Transplant Clinical Trials Network (BMT CTN) trials 0302 (n = 105, serum) and 0802 (n = 158, plasma) versus controls without aGVHD (n = 53, serum). Levels of EGF and VEGF-A were lower than in controls at the onset of aGVHD in both trials and higher with complete response to first-line aGVHD therapy in CTN 0802. FS and PlGF were elevated in aGVHD measured in either serum or plasma. At day 28 after initial aGVHD therapy, elevated FS was an independent negative prognostic factor for survival in both cohorts (hazard ratio, 9.3 in CTN 0302; 2.8 in CTN 0802). These data suggest that circulating AF are associated with clinical outcomes after aGVHD and, thus, may contribute to both pathogenesis and recovery