Probing into Emily’s Tragedy

A rose for Emily is regarded as the most famous short story written by William Faulker. Emily, the protagonist of the story, leads a tragic life. This paper contends that the main cause to her tragedy is her inharmonious relations with the society. Accordingly, this paper analyzes the relationship between Emily and the officials of the town, her father, the town residents and her relatives. Consequently, this paper concludes that the underlining reason for Emily’s tragedy is her failure in social relations. Key words: Emily, tragedy, inharmonious Résumé Une rose pour Emily est considéré comme la plus connue nouvelle de William Faulker. L’héroïne Emily mène une vie tragéqui. L’auteur pense que c’est ses relations inharmonieuses avec la société qui cause sa tragédie. Donc, cet article analyse les relaltions inharmonieuses entre Emily et les officiers du bourg, son père, les habitants du bourg et ses parents, et signale que la raison profonde de la tragédie d’Emily reside dans l’échec de ses relations sociales. Mots clés: Emily, la tragédie, inharmonieux 摘 要 《獻給愛米麗的玫瑰》被認為是威廉•福克納昀著名的短篇小說。小說女主人公愛米麗具有濃重的悲劇色彩。本文認為導致愛米麗悲劇的是她周圍社會的不和諧的關係。有鑒於此，本文分析了女主人公愛米麗與鎮上官員、其父親、鎮上居民以及其親戚的種種不和諧的關係，從而指出社會關係的失敗是導致愛米麗 悲劇的深刻原因。關鍵詞： 愛米麗；悲劇；不和

Particle diode: Rectification of interacting Brownian ratchets

Transport of Brownian particles interacting with each other via the Morse potential is investigated in the presence of an ac driving force applied locally at one end of the chain. By using numerical simulations, we find that the system can behave as a particle diode for both overdamped and underdamped cases. For low frequencies, the transport from the free end to the ac acting end is prohibited, while the transport from the ac acting end to the free end is permitted. However, the polarity of the particle diode will reverse for medium frequencies. There exists an optimal value of the well depth of the interaction potential at which the average velocity takes its maximum. The average velocity $\upsilon$ decreases monotonically with the system size $N$ by a power law $\upsilon \propto N^{-1}$.Comment: 7 pages, 9 figure

An association study between polymorphism of alcohol dehydrogenase (ADH1B), aldehyde dehydrogenase (ALDH2), cytochrome (CYP4502E1), Catechol-OMethyltransferase (COMT) and 5-hydroxytryptamine transporter (5-HTT)...

Full Title: An association study between polymorphism of alcohol dehydrogenase (ADH1B), aldehyde dehydrogenase (ALDH2), cytochrome (CYP4502E1), Catechol-OMethyltransferase (COMT) and 5-hydroxytryptamine transporter (5-HTT) genes in Yunnan Han population with alcohol dependenceAbstact: Alcohol dependence (AD) is a complex disease resulting from the inheritance of several susceptible genes and multiple environmental determinants. The aim of this study was to identify the genetic risk factors which include alcohol metabolizing genes and neurotransmitter related genes for alcoholism in Yunnan Han population. Eight allelic variants of five genes were genotyped from 332 Yunnan Han individuals (including 118 alcohol-dependent patients (DSM-IV criteria) and 214 controls) using PCRRFLP method. Those polymorphic sites included alcohol dehydrogenase (ADH1B), aldehyde dehydrogenase (ALDH2), cytochrome P-4502E1 (CYP2E1) PstI, Catechol-O-Methyltransferase (COMT) rs2075507 (5’region), rs737865 (intron1), rs4680 (Val158Met), rs165599 (3’region) and serotonin transporter (5-HTTLPR). Both genotype and allele frequencies of ALDH2 and CYP4502E1 as well as the allele frequency of ADH1B gene differed significantly between AD group and control group. The proportion of ALDH2 *1/*2 genotype and *2 allele was significantly smaller in patients than that in controls (X2 = 6.554, p = 0.038; X2 = 4.906, p = 0.027), while the proportion of c2 allele of CYP4502E1 was significantly higher (X2 = 4.410, p = 0.036). Compared with the controls, the frequencies of the 5-HTTLPR L/L genotype and COMT rs737865 C/C genotype were significantly lower in AD group. Twelve COMT haplotypes (rs2075507, rs737865, rs4680 and rs165599) defined as H1 to H12 were obtained in this major minority population. The prevalence of the haplotype H1 ‘‘A-C-A-A’’ was significantly greater in alcoholics than the prevalence in their respective control group. There were no significant differences in the genotype frequencies of the COMT rs2075507, rs4680 and rs165599 polymorphisms between alcoholics and controls. COMT rs2075507 and rs737865 polymorphisms were in complete linkage disequilibrium in Han population of Yunnan Province. This study indicates that polymorphisms of ADH1B, ALDH2, CYP4502E1, COMT and 5-HTT were significantly associated with AD in Han majority. The ADH1B *2, ALDH2 *2 alleles, 5-HTTLPR L/L genotype and C/C genotype of the COMT rs737865 polymorphism had an important role in reducing the risk of AD while the c2 allele of CYP4502E1 increased the risk of AD. Therefore, the A-C-A-A haplotype may be a dangerous factor leading to AD.Key words: Yunnan Han population, polymorphism, alcohol dependence, genetic risk factor

Serum ApoB levels in depressive patients: associated with cognitive deficits

Cognitive deficits have been regarded as one of the most significant clinical symptoms of depressive disorder. Accumulating evidence has shown that apolipoprotein B (ApoB) levels, which are responsible for inducing neurodegeneration, may be involved in cognitive deficits. This study examines cognitive deficits, and the correlation of serum ApoB levels with cognitive deficits of depressive disorder. 90 depressive patients and 90 healthy controls with matched age and gender were recruited. Cognition was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Serum ApoB levels in depressive patients were measured by immunoturbidimetric method. Our results showed that depressive patients had lower scores of cognition including RBANS total score and subscales of language and delayed memory (all, p \u3c 0.001) than healthy controls after controlling for the variables. The differences in cognitive functions also passed Bonferroni corrections. Serum ApoB levels were negatively correlated with delayed memory score in depressive patients (r = −0.30, p = 0.01). Furthermore, stepwise multivariate regression analysis indicated that serum ApoB levels independently contributed to delayed memory in depressive patients (t = −2.68, p = 0.01). Our findings support that serum ApoB levels may be involved in delayed memory decline in depressive patients. Depressive patients also experience greater cognitive deficits, especially in delayed memory and language than healthy controls