IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection

Funding: This work was funded by a Career Development Fellowship (1028634) and a project grant (GRNT1028641) awarded to AHa by the Australian National Health & Medical Research Council (NHMRC). IS was supported by The University of Queensland Centennial and IPRS Scholarships. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Effects of Engineered Nanoparticles on the Assembly of Exopolymeric Substances from Phytoplankton

The unique properties of engineered nanoparticles (ENs) that make their industrial applications so attractive simultaneously raise questions regarding their environmental safety. ENs exhibit behaviors different from bulk materials with identical chemical compositions. Though the nanotoxicity of ENs has been studied intensively, their unintended environmental impacts remain largely unknown. Herein we report experimental results of EN interactions with exopolymeric substances (EPS) from three marine phytoplankton species: Amphora sp., Ankistrodesmus angustus and Phaeodactylum tricornutum. EPS are polysaccharide-rich anionic colloid polymers released by various microorganisms that can assemble into microgels, possibly by means of hydrophobic and ionic mechanisms. Polystyrene nanoparticles (23 nm) were used in our study as model ENs. The effects of ENs on EPS assembly were monitored with dynamic laser scattering (DLS). We found that ENs can induce significant acceleration in Amphora sp. EPS assembly; after 72 hours EN-EPS aggregation reached equilibrium, forming microscopic gels of ∼4–6 µm in size. In contrast, ENs only cause moderate assembly kinetic acceleration for A. angustus and P. tricornutum EPS samples. Our results indicate that the effects of ENs on EPS assembly kinetics mainly depend on the hydrophobic interactions of ENs with EPS polymers. The cycling mechanism of EPS is complex. Nonetheless, the change of EPS assembly kinetics induced by ENs can be considered as one potential disturbance to the marine carbon cycle

Developing a virtual coach for chronic patients:A user study on the impact of similarity, familiarity and realism

Healthcare costs are increasing dramatically due to disproportional consumption of healthcare resources by chronic patients. Automated forms of health coaching can contribute to improved patient self-management while reducing costs due to increased scalability and availability of the use of human health coaches. Embodied Conversational Agents (ECAs) seem to be good candidates to function as automated coaches, as they introduce a social component to human-computer interactions which makes them particularly suitable to influence a user’s attitude or behavior. To date, there is limited knowledge on the impact of appearance-related characteristics of an ECA as a virtual coach among a chronically ill elderly population. The primary aim of this study is to investigate the impact of three appearance cues on user acceptance: (i) similarity; (ii) familiarity; and (iii) realism. Findings demonstrate that patients (a) preferred the realistic-looking ECA over the more stylized one; (b) showed no preference for the familiar over the unfamiliar ECAs (but did evaluate the unfamiliar ECAs as more positive than the familiar one); and (c) evaluated an ECA as virtual coach for self-management support as useful