Human-Like Guide Robot that Proactively Explains Exhibits

We developed an autonomous human-like guide robot for a science museum. Its identifies individuals, estimates the exhibits at which visitors are looking, and proactively approaches them to provide explanations with gaze autonomously, using our new approach called speak-and-retreat interaction. The robot also performs such relation-building behaviors as greeting visitors by their names and expressing a friendlier attitude to repeat visitors. We conducted a field study in a science museum at which our system basically operated autonomously and the visitors responded quite positively. First-time visitors on average interacted with the robot for about 9 min, and 94.74% expressed a desire to interact with it again in the future. Repeat visitors noticed its relation-building capability and perceived a closer relationship with it

Departure time choice equilibrium and optimal transport problems

This paper presents a systematic approach for analyzing the departure-time choice equilibrium (DTCE) problem of a single bottleneck with heterogeneous commuters. The approach is based on the fact that the DTCE is equivalently represented as a linear programming problem with a special structure, which can be analytically solved by exploiting the theory of optimal transport combined with a decomposition technique. By applying the proposed approach to several types of models with heterogeneous commuters, it is shown that the dynamic equilibrium distribution of departure times exhibits striking regularities under mild assumptions regarding schedule delay functions, in which commuters sort themselves according to their attributes, such as desired arrival times, schedule delay functions (value of times), and travel distances to a destination

A new look at departure time choice equilibrium models with heterogeneous users

This paper presents a systematic approach for analyzing the departure-time choice equilibrium (DTCE) problem of a single bottleneck with heterogeneous commuters. The approach is based on the fact that the DTCE is equivalently represented as a linear programming problem with a special structure, which can be analytically solved by exploiting the theory of optimal transport combined with a decomposition technique. By applying the proposed approach to several types of models with heterogeneous commuters, it is shown that (i) the essential condition for emerging equilibrium “sorting patterns,” which have been known in the literature, is that the schedule delay functions have the “Monge property,” (ii) the equilibrium problems with the Monge property can be solved analytically, and (iii) the proposed approach can be applied to a more general problem with more than two types of heterogeneities

骨髄間葉系細胞シートはラット脊髄離断損傷後にグリア瘢痕形成を抑制し、軸索再生と後肢運動機能改善を促進する。

OBJECTIVE Transplantation of bone marrow stromal cells (BMSCs) is a theoretical potential as a therapeutic strategy in the treatment of spinal cord injury (SCI). Although a scaffold is sometimes used for retaining transplanted cells in damaged tissue, it is also known to induce redundant immunoreactions during the degradation processes. In this study, the authors prepared cell sheets made of BMSCs, which are transplantable without a scaffold, and investigated their effects on axonal regeneration, glial scar formation, and functional recovery in a completely transected SCI model in rats. METHODS BMSC sheets were prepared from the bone marrow of female Fischer 344 rats using ascorbic acid and were cryopreserved until the day of transplantation. A gelatin sponge (GS), as a control, or BMSC sheet was transplanted into a 2-mm-sized defect of the spinal cord at the T-8 level. Axonal regeneration and glial scar formation were assessed 2 and 8 weeks after transplantation by immunohistochemical analyses using anti-Tuj1 and glial fibrillary acidic protein (GFAP) antibodies, respectively. Locomotor function was evaluated using the Basso, Beattie, and Bresnahan scale. RESULTS The BMSC sheets promoted axonal regeneration at 2 weeks after transplantation, but there was no significant difference in the number of Tuj1-positive axons between the sheet- and GS-transplanted groups. At 8 weeks after transplantation, Tuj1-positive axons elongated across the sheet, and their numbers were significantly greater in the sheet group than in the GS group. The areas of GFAP-positive glial scars in the sheet group were significantly reduced compared with those of the GS group at both time points. Finally, hindlimb locomotor function was ameliorated in the sheet group at 4 and 8 weeks after transplantation. CONCLUSIONS The results of the present study indicate that an ascorbic acid-induced BMSC sheet is effective in the treatment of SCI and enables autologous transplantation without requiring a scaffold.博士（医学）・甲第656号・平成28年11月24日© Copyright 2016 American Association of Neurological SurgeonsThe definitive version is available at " http://dx.doi.org/10.3171/2016.8.SPINE16250

Mechanosensory trichome cells evoke a mechanical stimuli–induced immune response in Arabidopsis thaliana

Perception of pathogen-derived ligands by corresponding host receptors is a pivotal strategy in eukaryotic innate immunity. In plants, this is complemented by circadian anticipation of infection timing, promoting basal resistance even in the absence of pathogen threat. Here, we report that trichomes, hair-like structures on the epidermis, directly sense external mechanical forces, including raindrops, to anticipate pathogen infections in Arabidopsis thaliana. Exposure of leaf surfaces to mechanical stimuli initiates the concentric propagation of intercellular calcium waves away from trichomes to induce defence-related genes. Propagating calcium waves enable effective immunity against pathogenic microbes through the CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 3 (CAMTA3) and mitogen-activated protein kinases. We propose an early layer of plant immunity in which trichomes function as mechanosensory cells that detect potential risks