RUNX oncoproteins and miRNA networks

News on: An AML1-ETO/miR-29b-1 regulatory circuit modulates phenotypic properties of acute myeloid leukemia cells by Zaidi et al. Oncotarget. 2017; 8:39994-40005. https://doi.org/10.18632/oncotarget.18127

THE TAKEOFF IN THE LONG JUMP AND OTHER RUNNING JUMPS

Despite its importance to success in the long jump, the takeoff has been accorded little attention by sports biomechanists. We conducted a study to determine the characteristics of an athlete's technique that determine the vertical velocity gained during the takeoff. We found that the vasti, soleus and gastrocnemius experienced a lengthening-shortening sequence of actions during the takeoff and that enhancement due to use of the stretchshollen cycle did not make a significant contribution to the vertical velocity developed via these muscles. Standing and running vertical jumps from a two-feet takeoff were found to involve different modes of muscle action. Running long and vertical jumps and sprinting involve almost identical modes of muscle action. The results of our study of the long jump appear, therefore, to apply to running jumps in general and to sprint running

Two-stage optimization method for efficient power converter design including light load operation

Power converter efficiency is always a hot topic for switch mode power supplies. Nowadays, high efficiency is required over a wide load range, e.g., 20%, 50% and 100% load. Computer-aided design optimization is developed in this research work, to optimize off-line power converter efficiency from light load to full load. A two-stage optimization method to optimize power converter efficiency from light load to full load is proposed. The optimization procedure first breaks the converter design variables into many switching frequency loops. In each fixed switching frequency loop, the optimal designs for 20%, 50% and 100% load are derived separately in the first stage, and an objective function using the optimization results in the first stage is formed in the second stage to consider optimizing efficiency at 20%, 50% and 100% load. Component efficiency models are also established to serve as the objective functions of optimizations. Prototypes 400V to 12V/25A 300W two-FET forward converters are built to verify the optimization results

Letter from James M. Hay to John Muir, [ca. 1901 Oct ?].

[D]P.S. Mend & bring your wife & daughters with you when you come.[A]Co\u27y & is now employed by an Insurance Co\u27y - with a good deal of Open air work. He is the Agent at Waterloo in the neighborhood of Liverpool, & comes occasionaly to spend the week end with us. When are you Coming to visit the old Country again? to inspect the glaciers, & tell us some of your wonderful stories. We would all like you to come & make this place your head quarters for a while You see you are a born traveller & I stay at home02731 [B]And finally & last of all What is to be done with those vagabond Anarchists! This dastardly assassniation of your worthy President has stirred the heart of the whole British poeple. Next to the death of our Noble Queen, there is nothing that has so universaly & so deeply touched us as this sad [event?]. The penalty for assassination of [illegible] [illegible] should be Solitary Confinement for life - &[C]& a similar punishment should be meted out to all those who preach & teach & recommend it, They are more culpable than the half witted crazy idiot who sometimes does the Deed. Now my dear Muir we all send our kindest regards. & let us know when your next visit to here is to come offYour affectionate CousinJas M Hay[pro.?] John MuirMartine

Preparation, Redox and Substitution Reactions of Solvated Metal Ions in Non Aqueous Media

Solvated iron(II), in MeCN solution, is prepared by oxidation of iron metal with WF6 , NOPF6 and PF5 or by fluoride ion transfer from FeF2 to PF5 or AsF5. Fe(NCMe)6 3+ is not produced from oxidation of iron metal, fluoride ion transfer from FeF3 or oxidation of Fe(NCMe)6 2+. Fe(NCMe)6 2+ is oxidised, by Cl2 producing FeCl4-. A ligand is necessary to stabilise Fe(lll) in MeCN

Origin and meaning of the New Testament term Parousia

Just at the time when the outline for this thesis had been determined and the work begun I had the disturbing privilege of reading the manuscript for chapter eight of James Barr's book 'The Semantics of Biblical Language' (1). In this chapter, entitled 'Some Principles of Kittel's Dictionary', Kittel is charged with pursuing a history of concepts by means of a dictionary of words. The pursuit of a history of concepts is of course recognised as quite valid, but not by means of the lexical method of the TWNT. This raised some questions in my own mind about the approach that I had adopted for this thesis. I had before me the article on ' parousia' by A. Oepke (2), which in some measure does merit the criticism made by James Barr (3). I also had before me the research of P. L. Schoonheim published under the title 'Een Semasiologisch Onderzoek Van Parousia' (4), which, as the title suggests, confines itself in large measure to a strictly linguistic analysis of the problem. It did not seem to me however that either quite answered the questions uppermost in my own mind: why did so many of the New Testament writers judge this term equal to the task of giving expression to the concept of the coming of Christ, and what is its relationship to that concept. With some hesitation I would suggest that Oepke failed in part because he was too much concerned with the larger concept of the coming of God to man, and Schoonheim because the task of exegesis was made subservient to his lingusitic analysis. In saying this of course I do not want for a moment to depreciate the value of either of these works. The latter especially I found to be most helpful. But the problem of the relationship of the word to the concept still remained, and great care had to be taken that the method by which these questions might be answered did not fall prey to the criticisms offered by Barr

An Investigation of the Reliability of Root and Shoot Growth Inhibition of Germinating Seedlings in Determining Relative Phytotoxicity of Various Chemical Compounds

Previous to 1940, sodium chlorate, certain boron compounds, and arsenic compounds were established as soil sterilants. Immediately prior to this time, the use of sulphuric acid and substituted phenols had attracted some attention and favor as selective herbicide. When 2, 4-D (2,4-dichlorophenoxyacetic acid) becomes available as an herbicide its spectacular efficiency not only facilitated its wide acceptance but also aroused a new and greater interests in chemical weed control. In response to demand for new herbicides to meet the recognized inadequacies of 2, 4-D and the older herbicides, many chemicals of possible herbicidal value are now being synthesized and screened by numerous formulators. The procedures of screening vary from simple single plant laboratory tests to extensive greenhouse and field trials. None of these procedures are completely satisfactory in that they were developed to estimate a reaction similar to that exhibited by hormone type growth regulators such as 2, 4-D. This paper reports a laboratory screening test designed to give an adequate evaluation of chemical compounds with respect to their herbicidal potentialities. The basis for this test was derived from earlier work done with systemic growth regulators, and it was recognized that the various compounds to be tested might not all react in a similar manner. Greenhouse trials with the same chemicals were run simultaneously to check the accuracy and reliability of the laboratory test

Letter from James M. Hay to John Muir, 1893 Sep 28.

Delta Chambers,Liverpool, 28 Sep., 1893. My dear Cousin Muir, We duly received your kind and interesting letter from on board the good ship Campania, and have since noticed the paragraph of her safe arrival in Hew York, having made a fairly good passage - as to time, of 5 3/4 days, barring the fogs. Since then, no doubt unless detained by friends there, you have been speeding across the continent of North America to your beloveds at home, in San Francisco, where I hope you found all well and glad to welcome you back. lour visit here, though short, was a very pleasant one to all of us, and leaves behind it pleasant memories. Now then, since after a lapse of 50 years we have got more fully in touch with each other we must let it go. Through the Lunams we have had an inkling now and then of your doings and often had a reading of your mother\u27s kind and affectionate letters to them, but now that you are no myth, and having seen you in the flesh and face to face, we shall look for a closer friendship and shall be glad of a fuller acquaintance of all your doings and your whereabouts. There are few who could be in greater sympathy with the business of your life or who would give a more attentive ear to its recital. I only wish there had been more time to have brought you in touch with some of our scientific men here, but cherish the hope that since you have found the way, and find it so easy, you may indulge us with a repetition of your visit and that before any of us are very much older. Maggie went home to Dunbar last Friday where her mother would have arrived an hour or two before her, having left Chernside for good. My wife left yesterday for Arnside for a few days\u27 quiet, perfect quiet, in the country - country of which she is so passionately fond. My eldest boy, John, just the Monday after you sailed, knocked us up, after the midnight hour, arriving then from his long walking ramble of five weeks in the finest condition of brown ruddy health. He resumes his work at University College next Monday. James is back to the School of Art. We all send our kindest love to you. My wee piggie sends her own special love to Helen and Wanda and wonders if Helen has learned to read as well as to write, the time you have been away! The enclosed two letters came a few days ago, one after the other. 1 hope they do not happen to be of pressing importance, for I did not hasten to dispatch them, thinking that others might follow, and I would send them all together, but there two are all that came. Our Rockferry friends Uncle Hardie and Aunt Polly and Aunt Sophia are all in their ordinary and would send their love too were tney at my elbow just now. Remember us all very kindly to your venerable old Mother, and remind her that altho we may never meet again on this earth, it is our joy to know that we shall all meet again in that House above of many mansions which our Father is preparing for us. Ever your affec. cousin, James Li. HayJohn Muir, Esq., Martinez, California

Letter from Ja[me]s M. Hay to [Margaret Hay] Lunam, 1893 Jul 9.

Mersey View House,Birkenhead, 9 July, 1893.My dear Mrs. Lunam;I duly received your note and was much interested in your account of Mr. John Muir\u27s visit. I write specially to say that no doubt when he is about to return to his American home he will do so by way of Liverpool, and we offer him a hearty welcome to our house here for the few days he may have to spare after his visit to Switzerland and the wonders of the Continent.I should like to introduce him to one or two here, Sir isdward Hussell, for example, a man of culture and who could introduce him to any other man it would be interesting to know. Now he .may have left Dunbar by this time for his tour in the Highlands, but surely you will have opportunities of communication with him from time to time. Wow mind and do this - let him be made acquainted with our desire. I would also take a run through with him to the famous city of Chester, which every American visits when first he comes to the old country.I am resting in bed this evening instead of going to church, which accounts for me using the pencil. I hope you and Maggie are both well and enjoying this glorious hot weather.and how is my old pet, your worthy pastor. I often sympathize with him fighting all alone as he does with those wild beasts at Sphesus. I would so like to see him wear the crown of victory here below before he passes away to wear it in celestial regions. My kind love to you both, and ever believe me,Your affectionate cousin,James M. HayMrs. Lunam,Westfield, Dunbar.Now don\u27t lose sight of John Muir, but urge my message upon him.0617