The influence of non-steroidal anti-inflammatory drugs and paracetamol used for pain control of orthodontic tooth movement: a systematic review

ABSTRACT The present study aimed to perform a systematic literature review to determine if there is a non-steroidal anti-inflammatory drug (NSAID) that interferes less within tooth movement. This research was performed according to the PRISMA statement. Articles were searched in eight electronic databases (PubMed, Scopus, Embase, Web of Science, LILACS, SciELO, Google Scholar, and Open Grey). Only experimental studies on male Wistar rats were selected, which included experiments related to the influence of NSAIDs on orthodontic movement. Studies in animals with pathological conditions, literature review articles, letters to the editor and/or editorials, case reports, abstracts, books, and book chapters were excluded. Each of the steps of this systematic literature review was performed by two examiners independently. Results: the total sample consisted of 505 articles, from which 6 studies were eligible after a qualitative analysis. From the drugs assessed, paracetamol was unanimous for not interfering within orthodontic movement when compared to the control group. However, drugs such as aspirin, ibuprofen, sodium diclofenac, and selective cyclooxygenase-2 inhibitors caused a reduction in tooth movement when compared to the control group. Conclusion: paracetamol could be considered the drug of choice for pain relief because it interferes less within tooth movement

Evaluation Of Root Resorption Associated With Orthodontic Movement In Stressed Rats.

AIM: The aim of this study was to investigate the effects of acute and chronic systemic stress response on orthodontically induced root resorption. METHODS: Male Wistar rats were restrained during 1 hour a day by stress models of short (3 days) and long duration (40 days), while control group was not submitted to restraint (N.=10/group). The upper left first molars of all rats were moved mesially by a fixed orthodontic appliance exerting 50 g force upon insertion during the last 14 days of the experiment. Then, animals were killed for blood collection and mensuration of plasmatic corticosterone by radioimmunoassay; the tissues around mesial root of the first molar were processed for histological and histochemical techniques with tartrate-resistant acid phosphatase. The degree of root resorption and the number of odontoclasts were evaluated, being the contralateral side of each animal serving as its control (split-mouth design). RESULTS: The results revealed that the plasmatic levels of corticosterone were significantly higher in both the stressed groups than in the control one. There were no significant differences in the degree of root resorption and in the number of odontoclasts on the root between the 3 groups studied. CONCLUSIONS: These results indicate that systemic stress alone can not be considered a risk factor for root resorption induced by orthodontic tooth movement.5711-1256957

Estudo da reabsorção radicular apical após o uso de aparelho extrabucal no tratamento da má oclusão do tipo Classe II, 1ª divisão dentária Study of apical root resorption after occipital headgear wear on the treatment of dental Class II, division 1 malocclusion

OBJETIVO: o presente estudo verificou o efeito do uso do aparelho extrabucal (AEB) sobre a intensidade da reabsorção radicular apical nos primeiros molares permanentes superiores submetidos à ação do aparelho. MÉTODOS: foram avaliadas as radiografias periapicais da região dos primeiros molares permanentes superiores, bilateralmente, de 19 jovens leucodermas, do gênero feminino, com idades entre 8 e 10 anos, com má oclusão do tipo Classe II, 1ª divisão dentária, pré e pós-tratamento com AEB de tração alta. As 76 radiografias foram divididas em dois grupos, de acordo com o grau de formação radicular. O grupo A consistiu de 18 radiografias com formação radicular incompleta, com exceção da raiz palatina, ao início do tratamento e 18 ao final. O grupo B consistiu de 20 radiografias com formação radicular completa ao início do tratamento e 20 ao final. Mensurou-se os comprimentos radiculares utilizando um paquímetro digital e submeteu-se as medidas obtidas ao teste de erro do método e à análise estatística (teste t de Student) para verificar as diferenças no comprimento radicular antes e após o tratamento com o AEB. RESULTADOS: no grupo A ocorreu um aumento significativo dos comprimentos radiculares, enquanto no grupo B as diferenças dos comprimentos radiculares não foram significativas. As medidas pós-tratamento no grupo A não diferiram das medidas pré-tratamento no grupo B, ou seja, os dentes com formação radicular incompleta ao início do tratamento apresentaram crescimento radicular normal durante o tratamento ativo. CONCLUSÃO: concluiu-se que o uso do AEB não influenciou negativamente na formação radicular e não provocou reabsorção apical nos molares submetidos à ação do aparelho, sugerindo que o AEB não apresentou riscos à estrutura e formação radicular quando corretamente indicado e aplicado.<br>AIM: The aim of this study was to verify the effect of occipital headgear wear on the intensity of apical root resorption of the upper first permanent molars submitted to the action of the appliance. METHODS: Were evaluated periapical X-rays of 19 leucoderms young female - with ages between 8 and 10 years, with dental Class II, division 1 malocclusion, before and after orthodontic treatment, using high-pull headgear. The 76 X-rays were divided into two groups according to their root formation. Group A consisted of 18 X-rays with incomplete root formation, except for the palatine root, before treatment and 18 after treatment. Group B consisted of 20 X-rays where root formation was completed before treatment and 20 after treatment. The root lengths were measured with digital caliper and the registered measures were submitted to the error of the method and statistical analysis, Student t test, to verify the differences regarding the root length before and after the treatment with occipital headgear. RESULTS: In group A, there was a significant increase of the root lengths, while in the group B the differences were not significant. Posttreatment Group A showed no significant differences with the mean root lengths of pretreatment group B, in other words, teeth with incomplete root formation at onset of orthodontic treatment presented normal root growth during the active treatment. CONCLUSION: Therefore, it was concluded that high-pull headgear didn't influence negatively in the root formation and it didn't provoke apical resorption of the molars submitted to the action of the appliance, suggesting that occipital headgear doesn't present risks to the root structure and formation when correctly indicated and applied