Co-ordinating retinal histogenesis: early cell cycle exit enhances early cell fate determination in the Xenopus retina

The laminar arrays of distinct cell types in the vertebrate retina are built by a histogenic process in which cell fate is correlated with birth order. To explore this co-ordination mechanistically, we altered the relative timing of cell cycle exit in the developing Xenopus retina and asked whether this affected the activity of neural determinants. We found that Xath5, a bHLH proneural gene that promotes retinal ganglion cell (RGC) fate, ( Kanekar, S., Perron, M., Dorsky, R., Harris, W. A., Jan, L. Y., Jan, Y. N. and Vetter, M. L. (1997) Neuron 19, 981-994), does not cause these cells to be born prematurely. To drive cells out of the cell cycle early, therefore, we misexpressed the cyclin kinase inhibitor, p27Xic1. We found that early cell cycle exit potentiates the ability of Xath5 to promote RGC fate. Conversely, the cell cycle activator, cyclin E1, which inhibits cell cycle exit, biases Xath5-expressing cells toward later neuronal fates. We found that Notch activation in this system caused cells to exit the cell cycle prematuely, and when it is misexpressed with Xath5, it also potentiates the induction of RGCs. The potentiation is counteracted by co-expression of cyclin E1. These results suggest a model of histogenesis in which the activity of factors that promote early cell cycle exit enhances the activity of factors that promote early cellular fates

Enhancement of Kerr nonlinearity via multi-photon coherence

We propose a new method of resonant enhancement of optical Kerr nonlinearity using multi-level atomic coherence. The enhancement is accompanied by suppression of the other linear and nonlinear susceptibility terms of the medium. We show that the effect results in a modification of the nonlinear Faraday rotation of light propagating in an Rb87 vapor cell by changing the ellipticity of the light.Comment: 4 pages, 3 figures Submitted to Optics Letter

On the Formation of Galaxy Halos: Comparing NGC 5128 and the Local Group Members

The metallicity distribution function (MDF) for the old red-giant stars in the halo of NGC 5128, the nearest giant elliptical galaxy, is virtually identical with the MDF for the old-disk stars in the LMC and also strongly resembles the halo MDF in M31. These galaxies all have high mean halo metallicities ( ~ -0.4$) with very small proportions of low-metallicity stars. These observations reinforce the view that metal-rich halos are quite normal for large galaxies of all types. Such systems are unlikely to have built up by accretion of pre-existing, gas-free small satellite galaxies, unless these satellites had an extremely shallow mass distribution (d log N / d log M > -1). We suggest that the halo of NGC 5128 is more likely to have assembled from hierarchical merging of gas-rich lumps in which the bulk of star formation took place during or after the merger stage.Comment: 10 pages, LaTeX, plus 3 figures in separate postscript files; Astronomical Journal, in press for December 200

Analysis of rolling bearing power loss models for twin screw oil injected compressor

The mechanical losses inside a screw compressor limit the performance of the compressor in terms of efficiency. These losses arise due to relative motion between elements inside the screw compressor. The estimation of mechanical losses predicted in the literature is around 10-15% of the total shaft power. One of the elements which contribute significantly to these losses is rolling element bearings. There are numerous mathematical models available which predict power losses in the rolling bearings. The objective of this paper is to study different models to predict power loss for rolling bearings and to predict the power losses for the bearings used for oil injected, twin screw compressor. A comparison between different power loss models for different operating conditions of compressor is also presented in this paper and results of analysis are compared with available experimental observations. The analysis helps to determine suitable power loss model for different operating conditions and more realistic predictions of the power losses. This allows designers for more accurate estimation of the performance of screw compressors

Large-N theory of strongly commensurate dirty-bosons: absence of transition in two dimensions

The spherical limit of strongly commensurate dirty-bosons is studied perturbatively at weak disorder and numerically at strong disorder in two dimensions (2D). We argue that disorder is not perfectly screened by interactions, and consequently that the ground state in the effective Anderson localisation problem always remains localised. As a result there is only a gapped Mott insulator phase in the theory. Comparisons with other studies and the parallel with disordered fermions in 2D are discussed. We conjecture that while for the physical cases N=2 (XY) and N=1 (Ising) the theory should have the ordered phase, it may not for N=3 (Heisenberg).Comment: 15 pages, 4 figures. Minor typographical errors correcte

Sagnac interferometry based on ultra-slow polaritons in cold atomic vapors

The advantages of light and matter-wave Sagnac interferometers -- large area on one hand and high rotational sensitivity per unit area on the other -- can be combined utilizing ultra-slow light in cold atomic gases. While a group-velocity reduction alone does not affect the Sagnac phase shift, the associated momentum transfer from light to atoms generates a coherent matter-wave component which gives rise to a substantially enhanced rotational signal. It is shown that matter-wave sensitivity in a large-area interferometer can be achieved if an optically dense vapor at sub-recoil temperatures is used. Already a noticeable enhancement of the Sagnac phase shift is possible however with much less cooling requirements.Comment: 4 pages, 3 figure

Deep learning with convolutional neural networks for decoding and visualization of EEG pathology

We apply convolutional neural networks (ConvNets) to the task of distinguishing pathological from normal EEG recordings in the Temple University Hospital EEG Abnormal Corpus. We use two basic, shallow and deep ConvNet architectures recently shown to decode task-related information from EEG at least as well as established algorithms designed for this purpose. In decoding EEG pathology, both ConvNets reached substantially better accuracies (about 6% better, ~85% vs. ~79%) than the only published result for this dataset, and were still better when using only 1 minute of each recording for training and only six seconds of each recording for testing. We used automated methods to optimize architectural hyperparameters and found intriguingly different ConvNet architectures, e.g., with max pooling as the only nonlinearity. Visualizations of the ConvNet decoding behavior showed that they used spectral power changes in the delta (0-4 Hz) and theta (4-8 Hz) frequency range, possibly alongside other features, consistent with expectations derived from spectral analysis of the EEG data and from the textual medical reports. Analysis of the textual medical reports also highlighted the potential for accuracy increases by integrating contextual information, such as the age of subjects. In summary, the ConvNets and visualization techniques used in this study constitute a next step towards clinically useful automated EEG diagnosis and establish a new baseline for future work on this topic.Comment: Published at IEEE SPMB 2017 https://www.ieeespmb.org/2017

Symmetric photon-photon coupling by atoms with Zeeman-split sublevels

We propose a simple scheme for highly efficient nonlinear interaction between two weak optical fields. The scheme is based on the attainment of electromagnetically induced transparency simultaneously for both fields via transitions between magnetically split F=1 atomic sublevels, in the presence of two driving fields. Thereby, equal slow group velocities and symmetric cross-coupling of the weak fields over long distances are achieved. By simply tuning the fields, this scheme can either yield giant cross-phase modulation or ultrasensitive two-photon switching.Comment: Modified scheme, 4 pages, 1 figur

Cooling and squeezing via quadratic optomechanical coupling

We explore the physics of optomechanical systems in which an optical cavity mode is coupled parametrically to the square of the position of a mechanical oscillator. We derive an effective master equation describing two-phonon cooling of the mechanical oscillator. We show that for high temperatures and weak coupling, the steady-state phonon number distribution is non-thermal (Gaussian) and that even for strong cooling the mean phonon number remains finite. Moreover, we demonstrate how to achieve mechanical squeezing by driving the cavity with two beams. Finally, we calculate the optical output and squeezing spectra. Implications for optomechanics experiments with the membrane-in-the-middle geometry or ultracold atoms in optical resonators are discussed.Comment: 4 pages, 3 figure