Home-range use patterns and movements of the Siberian flying squirrel in urban forests: Effects of habitat composition and connectivity

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Epigenetic regulation of mucin genes in human cancers

Mucins are high molecular weight glycoproteins that play important roles in diagnostic and prognostic prediction and in carcinogenesis and tumor invasion. Regulation of expression of mucin genes has been studied extensively, and signaling pathways, transcriptional regulators, and epigenetic modification in promoter regions have been described. Detection of the epigenetic status of cancer-related mucin genes is important for early diagnosis of cancer and for monitoring of tumor behavior and response to targeted therapy. Effects of micro-RNAs on mucin gene expression have also started to emerge. In this review, we discuss the current views on epigenetic mechanisms of regulation of mucin genes (MUC1, MUC2, MUC3A, MUC4, MUC5AC, MUC5B, MUC6, MUC16, and MUC17) and the possible clinical applications of this epigenetic information

Are habitat loss, predation risk and climate related to the drastic decline in a Siberian flying squirrel population? A 15 year study

To devise effective conservation actions, it is important to know which factors are associated with the population parameters of a declining population. Using mark–recapture methods, we estimated the annual population size, growth rate and survival probability of an ear-tagged flying squirrel population over a 15-year period in a 4,500 ha study area in western Finland. The species is considered vulnerable, but detailed knowledge concerning population sizes or trends is lacking. The population parameters and changes therein were regressed against habitat availability, an indicator of predation pressure, and mean winter temperature (an indicator of climate change), to reveal potential reasons for trends in the population. The best-fit models suggested the annual growth rate to be below one, and on average it was 0.93 (±0.06; SE) across the 15-year period. The survival probability was about 0.22 (±0.03) for juveniles and 0.50 (±0.03) for adults. The population size of adult flying squirrels decreased from 65 (±11) individuals in 1995 to 29 (±6) individuals in 2009. The number of flying squirrels was associated with the amount of available habitat, but the decline in population size was more rapid than the loss of habitat area. If the current decreasing trend in habitat availability continues, the population might become extinct by the year 2020. To halt the population decline, it is necessary to refrain from clear-cutting mature spruce stands until new suitable habitats develop from the maturation of younger forests.peerReviewe