Patientenorientierte Versorgung chronisch Kranker

Schaeffer D, Müller-Mundt G. Patientenorientierte Versorgung chronisch Kranker. In: Pfaff H, Schrappe M, Lauterbach KW, Engelmann U, Halber M, eds. Gesundheitsversorgung und Disease-Management. Grundlagen und Anwendungen der Versorgungsforschung. Bern, Göttingen, Toronto, Seattle: Huber; 2003: 143-148

Impairment of neocortical metabolism predicts progression in Alzheimer's disease

Studied prediction of progression rates of Alzheimer's disease (AD) in a prospective multicenter cohort study of 186 patients (mean age 63.2 yrs) with possible or probable AD, mostly with presenile onset. In a cross-sectional analysis at entry, impairment of glucose metabolism in temporoparietal or frontal association areas measured with positron emission tomography was significantly associated with dementia severity, clinical classification as possible vs probable AD, presence of multiple cognitive deficits and history of progression. A prospective longitudinal analysis showed a significant association between initial metabolic impairment and subsequent clinical deterioration. In patients with mild cognitive deficits at entry, the risk of deterioration was up to 4.7 times higher if the metabolism was severely impaired than with mild or absent metabolic impairment