33 research outputs found
Microwave-assisted synthesis of meso-carboxyalkyl-BODIPYs and an application to fluorescence imaging
Please read abstract in the article.http://pubs.rsc.org/en/Journals/JournalIssues/OB2021-09-21hj2021Nuclear Medicin
Teaching of Energy Issues: A debate proposal for a GLobal Reorientation
The growing awareness of serious difficulties in the learning of energy issues has produced a great deal of research, most of which is focused on specific conceptual aspects. In our opinion, the difficulties pointed out in the literature are interrelated and connected to other aspects (conceptual as well as procedural and axiological), which are not sufficiently taken into account in previous research. This paper aims to carry out a global analysis in order to avoid the more limited approaches that deal only with individual aspects. From this global analysis we have outlined 24 propositions that are put forward for debate to lay the foundations for a profound reorientation of the teaching of energy topics in upper high school courses, in order to facilitate a better scientific understanding of these topics, avoid many students' misconceptions and enhance awareness of the current situation of planetary emergency
Towards the Development of a Targeted Albumin-Binding Radioligand for Theranostic Applications: Synthesis, Radiolabelling and Preliminary In Vivo Studies
GluCAB is a newly synthesised macrocyclic radioligand designed to bind in vivo to albumin (HSA) for the purpose of development as a dual-targeting oncological theranostic agent. Subsequent to its synthesis and 64Cu-radiolabelling, this radioligand has show a prolonged circulation time in healthy mice but with appropriate systemic clearance within 24 h. This radioligand meets the criteria to be further investigated for tumour targeting and uptake
In Vivo Albumin-Binding of a C-Functionalized Cyclam Platform for 64Cu-PET/CT Imaging in Breast Cancer Model
In the aim to design small molecules capable of binding in vivo to albumin to form
bioconjugates, a second generation GluCAB derivative(Glucose-Chelator-Albumin
Bioconjugate) has been synthesized and studied for in vivo 64Cu-PET/CT imaging in breast cancer mice models
together with its first-generation analogue. This series of radioligands - also
capable of complexing therapeutic isotopes and therefore classified as
theranostic agents - are working on the principle of tumor targeting through
the Enhanced Permeability and Retention (EPR) effect as well as glucose
metabolism