Combined endoscopic and laparoscopic surgery (CELS) for early colon cancer in high-risk patients

Background Local excision of early colon cancers could be an option in selected patients with high risk of complications and no sign of lymph node metastasis (LNM). The primary aim was to assess feasibility in high-risk patients with early colon cancer treated with Combined Endoscopic and Laparoscopic Surgery (CELS). Methods A non-randomized prospective feasibility study including 25 patients with Performance Status score ≥ 1 and/or American Society of Anesthesiologists score ≥ 3, and clinical Union of International Cancer Control stage-1 colon cancer suitable for CELS resection. The primary outcome was failure of CELS resection, defined as either: Incomplete resection (R1/R2), local recurrence within 3 months, complication related to CELS within 30 days (Clavien–Dindo grade ≥ 3), death within 30 days or death within 90 days due to complications to surgery. Results Fifteen patients with clinical T1 (cT1) and ten with clinical T2 (cT2) colon cancer and without suspicion of metastases were included. Failure occurred in two patients due to incomplete resections. Histopathological examination classified seven patients as having pT1, nine as pT2, six as pT3 adenocarcinomas, and three as non-invasive tumors. In three patients, the surgical strategy was changed intraoperatively to conventional colectomy due to tumor location or size. Median length of stay was 1 day. Seven patients had completion colectomy performed due to histological high-risk factors. None had LNM. Conclusions In selected patients, CELS resection was feasible, and could spare some patients large bowel resection

明人“传奇”称名的观念基础及其渊源

A chemically selective laser ion source has been used in a $\beta$-decay study of heavy Ag isotopes into even-even Cd nuclides. Gamma-spectroscopic techniques in time-resolving event-by-event and multiscaling modes have permitted the identification of the first 2$^+$ and 4$^+$ levels in $^{126}$Cd$_{78}$, $^{128}$Cd$_{80}$, and tentatively the 2$^+$ state in $^{130}$Cd$_{82}$. From a comparison of these new states in $_{48}$Cd with the $E(2^+)$ and $E(4^+)/E(2^+)$ level systematics of $_{46}$Pd and $_{52}$Te isotopes and several recent model predictions, possible evidence for a weakening of the spherical $N=82$ neutron-shell below double-magic $^{132}$Sn is obtained