51 research outputs found
Effects of viscous dissipation and boundary conditions on forced convection in a channel occupied by a saturated porous medium
Forced convection with viscous dissipation in a parallel plate channel filled by a saturated porous medium is investigated numerically. Three different viscous dissipation models are examined. Two different sets of wall conditions are considered: isothermal and isoflux. Analytical expressions are also presented for the asymptotic temperature profile and the asymptotic Nusselt number. With isothermal walls, the Brinkman number significantly influences the developing Nusselt number but not the asymptotic one. At constant wall heat flux, both the developing and the asymptotic Nusselt numbers are affected by the value of the Brinkman number. The Nusselt number is sensitive to the porous medium shape factor under all conditions considered
Effects of viscous dissipation and boundary conditions on forced convection in a channel occupied by a saturated porous medium
Forced convection with viscous dissipation in a parallel plate channel filled by a saturated porous medium is investigated numerically. Three different viscous dissipation models are examined. Two different sets of wall conditions are considered: isothermal and isoflux. Analytical expressions are also presented for the asymptotic temperature profile and the asymptotic Nusselt number. With isothermal walls, the Brinkman number significantly influences the developing Nusselt number but not the asymptotic one. At constant wall heat flux, both the developing and the asymptotic Nusselt numbers are affected by the value of the Brinkman number. The Nusselt number is sensitive to the porous medium shape factor under all conditions considered
Non Linear Current Response of a Many-Level Tunneling System: Higher Harmonics Generation
The fully nonlinear response of a many-level tunneling system to a strong
alternating field of high frequency is studied in terms of the
Schwinger-Keldysh nonequilibrium Green functions. The nonlinear time dependent
tunneling current is calculated exactly and its resonance structure is
elucidated. In particular, it is shown that under certain reasonable conditions
on the physical parameters, the Fourier component is sharply peaked at
, where is the spacing between
two levels. This frequency multiplication results from the highly nonlinear
process of photon absorption (or emission) by the tunneling system. It is
also conjectured that this effect (which so far is studied mainly in the
context of nonlinear optics) might be experimentally feasible.Comment: 28 pages, LaTex, 7 figures are available upon request from
[email protected], submitted to Phys.Rev.
The role of sulfoglucuronosyl glycosphingolipids in the pathogenesis of monoclonal IgM paraproteinemia and peripheral neuropathy
In IgM paraproteinemia and peripheral neuropathy, IgM M-protein secretion by B cells leads to a T helper cell response, suggesting that it is antibody-mediated autoimmune disease involving carbohydrate epitopes in myelin sheaths. An immune response against sulfoglucuronosyl glycosphingolipids (SGGLs) is presumed to participate in demyelination or axonal degeneration in the peripheral nervous system (PNS). SGGLs contain a 3-sulfoglucuronic acid residue that interacts with anti-myelin-associated glycoprotein (MAG) and the monoclonal antibody anti-HNK-1. Immunization of animals with sulfoglucuronosyl paragloboside (SGPG) induced anti-SGPG antibodies and sensory neuropathy, which closely resembles the human disease. These animal models might help to understand the disease mechanism and lead to more specific therapeutic strategies. In an in vitro study, destruction or malfunction of the blood-nerve barrier (BNB) was found, resulting in the leakage of circulating antibodies into the PNS parenchyma, which may be considered as the initial key step for development of disease
Genetic alterations in the 3q26.31-32 locus confer an aggressive prostate cancer phenotype
10.1038/s42003-020-01175-xCommunications Biology3144
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