72,724 research outputs found
Growth Patterns in the First Three Years of Life in Children with Classical Congenital Adrenal Hyperplasia Diagnosed by Newborn Screening and Treated with Low Doses of Hydrocortisone
Background: Linear growth is the best clinical parameter for monitoring metabolic control in classical congenital adrenal hyperplasia (CAH). Objective: To analyze growth patterns in children with CAH diagnosed by newborn screening and treated with relatively low doses of hydrocortisone during the first year of life. Patients and Methods: 51 patients (27 females) were diagnosed with classical CAH by newborn screening. All patients were treated with relatively low doses of hydrocortisone (9-15 mg/m(2) body surface area). 47 patients were additionally treated with fludrocortisone. Results: At birth, height SDS (H-SDS) was 1.1 +/- 1 in girls and 0.9 +/- 1.5 in boys. After 3 months, H-SDS decreased to 0.4 +/- 0.9 in girls and to 0.1 +/- 1.3 in boys. Over the 3-year period, H-SDS further decreased to -0.4 +/- 1.8 in girls and to -0.8 +/- 1 in boys and approached the genetic height potential (target H-SDS of girls -0.5 +/- 0.3 and target H-SDS of boys -0.9 +/- 0.7). During the first 9 months of age, growth velocity was slightly decreased in girls (18.2 +/- 1.9 cm) and boys (17.3 +/- 1.6 cm) when compared to a healthy reference population (girls 19.0 +/- 3.9 cm and boys 18.7 +/- 4.7 cm). At the age of 3 years, bone age was appropriate for chronological age in both girls (2.7 +/- 0.5 years) and boys (2.9 +/- 0.5 years). Conclusion: Birth length is above average in children with classical CAH, which might be the result of untreated hyperandrogenism in utero. With relatively low doses of hydrocortisone treatment, growth velocity decreases slightly during the first 9 months and H-SDS then approaches the genetic height potential. Copyright (C) 2010 S. Karger AG, Base
Effective models for gapped phases of strongly correlated quantum lattice models
We present a robust scheme to derive effective models non-perturbatively for
quantum lattice models when at least one degree of freedom is gapped. A
combination of graph theory and the method of continuous unitary
transformations (gCUTs) is shown to efficiently capture all zero-temperature
fluctuations in a controlled spatial range. The gCUT can be used either for
effective quasi-particle descriptions or for effective low-energy descriptions
in case of infinitely degenerate subspaces. We illustrate the method for 1d and
2d lattice models yielding convincing results in the thermodynamic limit. We
find that the recently discovered spin liquid in the Hubbard model on the
honeycomb lattice lies outside the perturbative strong-coupling regime. Various
extensions and perspectives of the gCUT are discussed.Comment: 6 pages, 5 figures, extended discussion on J2/J1 for the honeycomb
Hubbard model and on the properties of different generators for the
continuous unitary transformatio
Optimized implementation of the Lanczos method for magnetic systems
Numerically exact investigations of interacting spin systems provide a major
tool for an understanding of their magnetic properties. For medium size systems
the approximate Lanczos diagonalization is the most common method. In this
article we suggest two improvements: efficient basis coding in subspaces and
simple restructuring for openMP parallelization.Comment: 9 pages, 2 figues, submitted to Journal of Computational Physic
Unifying Magnons and Triplons in Stripe-Ordered Cuprate Superconductors
Based on a two-dimensional model of coupled two-leg spin ladders, we derive a
unified picture of recent neutron scattering data of stripe-ordered
La_(15/8)Ba_(1/8)CuO_4, namely of the low-energy magnons around the
superstructure satellites and of the triplon excitations at higher energies.
The resonance peak at the antiferromagnetic wave vector Q_AF in the
stripe-ordered phase corresponds to a saddle point in the dispersion of the
magnetic excitations. Quantitative agreement with the neutron data is obtained
for J= 130-160 meV and J_cyc/J = 0.2-0.25.Comment: 4 pages, 4 figures included updated version taking new data into
account; factor in spectral weight corrected; Figs. 2 and 4 change
Bounds on universal quantum computation with perturbed 2d cluster states
Motivated by the possibility of universal quantum computation under noise
perturbations, we compute the phase diagram of the 2d cluster state Hamiltonian
in the presence of Ising terms and magnetic fields. Unlike in previous analysis
of perturbed 2d cluster states, we find strong evidence of a very well defined
cluster phase, separated from a polarized phase by a line of 1st and 2nd order
transitions compatible with the 3d Ising universality class and a tricritical
end point. The phase boundary sets an upper bound for the amount of
perturbation in the system so that its ground state is still useful for
measurement-based quantum computation purposes. Moreover, we also compute the
local fidelity with the unperturbed 2d cluster state. Besides a classical
approximation, we determine the phase diagram by combining series expansions
and variational infinite Projected entangled-Pair States (iPEPS) methods. Our
work constitutes the first analysis of the non-trivial effect of few-body
perturbations in the 2d cluster state, which is of relevance for experimental
proposals.Comment: 7 pages, 4 figures, revised version, to appear in PR
Fate of the cluster state on the square lattice in a magnetic field
The cluster state represents a highly entangled state which is one central
object for measurement-based quantum computing. Here we study the robustness of
the cluster state on the two-dimensional square lattice at zero temperature in
the presence of external magnetic fields by means of different types of
high-order series expansions and variational techniques using infinite
Projected Entangled Pair States (iPEPS). The phase diagram displays a
first-order phase transition line ending in two critical end points.
Furthermore, it contains a characteristic self-dual line in parameter space
allowing many precise statements. The self-duality is shown to exist on any
lattice topology.Comment: 12 pages, 9 figure
Newtonian Limit of Conformal Gravity
We study the weak-field limit of the static spherically symmetric solution of
the locally conformally invariant theory advocated in the recent past by
Mannheim and Kazanas as an alternative to Einstein's General Relativity. In
contrast with the previous works, we consider the physically relevant case
where the scalar field that breaks conformal symmetry and generates fermion
masses is nonzero. In the physical gauge, in which this scalar field is
constant in space-time, the solution reproduces the weak-field limit of the
Schwarzschild--(anti)DeSitter solution modified by an additional term that,
depending on the sign of the Weyl term in the action, is either oscillatory or
exponential as a function of the radial distance. Such behavior reflects the
presence of, correspondingly, either a tachion or a massive ghost in the
spectrum, which is a serious drawback of the theory under discussion.Comment: 9 pages, comments and references added; the version to be published
in Phys. Rev.
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