Cumulative Exposure Assessment of Triazole Pesticides

In the EFSA opinion on identification of new approaches to assess cumulative and synergistic risks from pesticides to human health a tiered approach for cumulative risk assessment has been proposed. The first tier is a deterministic approach using average and large portion consumption statistics. The higher tiers include probabilistic exposure assessment and Benchmark Dose (BMD) modeling. The aim of this study is to demonstrate the feasibility and applicability of a higher tier assessment of cumulative exposure using probabilistic modeling in combination with the relative potency factor (RPF) approach. The RPFs are used to weigh the toxicity of each pesticide relative to the toxicity of a chosen index compound (pesticide). In this report the authors address both the short-term and long-term cumulative exposure to triazoles using different statistical model

Impact of foods with health logo on ssaturated fat, sodium and sugar intake of young Dutch adults

Objective Health logos are introduced to distinguish foods with ‘healthier’ nutrient composition from regular foods. In the present study, we evaluated the effects of changed food compositions according to health logo criteria on the intake of saturated fat, sugar and sodium in a Dutch population of young adults. Design Foods in the Dutch food composition table were evaluated against nutrient criteria for logo eligibility. Three replacement scenarios were compared with the nutrient intake ‘as measured’ in the Dutch consumption survey. The foods not complying with health logo criteria were replaced either by ‘virtual’ foods exactly complying with the health logo criteria, with real 2007 market shares (scenario I) and 100 % market shares (scenario II), or by existing similar foods with a composition that already complied with the health logo criteria (scenario III). Results The percentage reduction in nutrient intake with the current 2007 market shares of ‘health logo foods’ was -2·5 % for SFA, 0 % for sodium and -1 % for sugar. With a 100 % market share these reductions would be -10 % for SFA, -4 % for sodium and -6 % for sugar. This may lead to a reduction of -40 % for SFA, -23 % for sodium and -36 % for sugar in the most optimal replacement scenario. Conclusions With ‘health logo foods’, available in 2007 and current consumption patterns, small reductions can be achieved for SFA and sugar. For additional reductions, lowering the fat/sodium content of meat (products) towards health logo criteria and drinks without sugar towards limits far below health logo criteria would be the most effective reformulation strategy

The 2008 Dutch NRL/IAG proficiency test for detection of animal proteins in feed

The results of a proficiency test for the detection of animal proteins in animal feed by microscopy, PCR (DNA detection) and immunoassay methods are presented in this report

THE RESOURCE NEXUS Preface and introduction to the Routledge Handbook

Demand for natural resources has grown rapidly for decades, and is expected to continue growing. These trends lead to repercussions, risks, and threats for humans and ecosystems at different scales. The challenges of sustainable resource management and governance are on numerous agendas, ranging from the G7 and G20 summits to UNEP’s International Resource Panel, World Economic Forum, SDG implementation, and a growing community of international scholars. Research highlights the importance of accounting for the interdependencies of resource use and sustainability goals such as eliminating hunger, mitigating climate change, and expanding energy access. There is a need to understand interdependencies and the feasibility of more integrated approaches. Debate is often framed in terms of a “nexus” between water, energy, and food (sometimes including other resources). The main aim of this handbook is to come to grips with what the nexus is about, provide a reference textbook with an overview, and a survey on emerging and cutting-edge research, and application of the concept. This handbook is edited by five dedicated scholars, drawing on different schools of thought from different continents. Assembling a wide group of more than 50 authors across a host of disciplines and interdisciplinary fields, this volume rests on a thorough review of relevant literature and, in emerging with a distinct and original perspective, it conceptualizes the resource nexus as a heuristic for understanding critical interlinkages between uses of different natural resources for systems of provision such as water, energy, and food. The editors organized a symposium which took place in London in March 2015, debating various aspects of the resource nexus and refining the concept and defining the structure of the handbook. All chapters have been reviewed several times

The Importance of DNA Repair in Tumor Suppression

The transition from a normal to cancerous cell requires a number of highly specific mutations that affect cell cycle regulation, apoptosis, differentiation, and many other cell functions. One hallmark of cancerous genomes is genomic instability, with mutation rates far greater than those of normal cells. In microsatellite instability (MIN tumors), these are often caused by damage to mismatch repair genes, allowing further mutation of the genome and tumor progression. These mutation rates may lie near the error catastrophe found in the quasispecies model of adaptive RNA genomes, suggesting that further increasing mutation rates will destroy cancerous genomes. However, recent results have demonstrated that DNA genomes exhibit an error threshold at mutation rates far lower than their conservative counterparts. Furthermore, while the maximum viable mutation rate in conservative systems increases indefinitely with increasing master sequence fitness, the semiconservative threshold plateaus at a relatively low value. This implies a paradox, wherein inaccessible mutation rates are found in viable tumor cells. In this paper, we address this paradox, demonstrating an isomorphism between the conservatively replicating (RNA) quasispecies model and the semiconservative (DNA) model with post-methylation DNA repair mechanisms impaired. Thus, as DNA repair becomes inactivated, the maximum viable mutation rate increases smoothly to that of a conservatively replicating system on a transformed landscape, with an upper bound that is dependent on replication rates. We postulate that inactivation of post-methylation repair mechanisms are fundamental to the progression of a tumor cell and hence these mechanisms act as a method for prevention and destruction of cancerous genomes.Comment: 7 pages, 5 figures; Approximation replaced with exact calculation; Minor error corrected; Minor changes to model syste