97 research outputs found
Incorporation of galactomannans in the diet of newly weaned piglets: Effect on bacteriological and some morphological characteristics of the small intestine
Copper phytoextraction with willow (Salix viminalis L.) under various Ca/Mg ratios. Part 1. Copper accumulation and plant morphology changes
Adição de Lipídios na Ração de Vacas Leiteiras: Parâmetros Fermentativos Ruminais, Produção e Composição do Leite
The GH/IGF1 axis in the kidney of young goats fed a protein-reduced diet
Feeding approaches for ruminants are changing to reduce N excretion as a major source of pollution. Based on the ruminohepatic cycle of N, it was assumed that the metabolism of ruminants could tolerate a reduced-protein diet well. However, metabolic changes such as a reduction in hepatic IGF1 mRNA expression, resulting in lower blood IGF1 levels due to decreased hepatic growth hormone receptor (GHR) expression, were found. Therefore, the aim of the present study was to determine the effect of a low-protein diet on the expression of GHR and subsequent IGF1 signalling in the renal cortex of young male goats to verify whether organ-specific synthesis of IGF1 mRNA expression occurs. Kidney cortex samples were obtained from eight goats fed a control diet (20% CP) and nine animals fed a reduced-protein diet (9% CP). The expression of GHR in the kidneys was reduced, whereas the expression of Janus kinase 2 (JAK2), suppressor of cytokine signalling 3 and signal transducers and activators of transcription 3 (STAT3) increased significantly. The stimulated JAK2 expression could modulate the expression of STAT3, which led to increased renal IGF1 mRNA expression. These results suggest that this increase in IGF1 mRNA expression in the kidneys is tissue-specific. This could be due to the autocrine/paracrine IGF1 effect on renal cell metabolism during a protein-reduced diet. These signalling pathways need further investigation to understand how and why low levels of protein stimulate IGF1 synthesis differently in the kidney than in the liver
Binding of biotinylated legume seed lectins with glycoproteins in blotted receptor-analogs: influence of incubation pH.
Increasing amounts of peas in the diet fed without or with spray-dried porcine plasma: effects on zootechnical performance of piglets
Biotechnologie en verbetering van de (voeder) verbetering. Op studiedag 'De zin van voederenzymes anno 1992', ingericht door NV Producten Trouw, 6 december 1991.
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