a0(980)-f0(980) mixing and isospin violation in the reactions pN -> d a0, pd -> 3He/3H a0 and dd -> 4He a0

It is demonstrated that f_0-a_0 mixing can lead to a comparatively large isospin violation in the reactions pN -> da_0, pd -> ^3He/^3H a_0 and dd -> ^4He a_0 close to the corresponding production thresholds. The observation of such mixing effects is possible, e.g., by measuring the forward-backward asymmetry in the reaction pn -> d a_0^0 -> d eta pi^0.Comment: 14 pages, 5 figure

Nonmesonic decay of the Lambda-hyperon in hypernuclei produced by p+Au collisions

The lifetime of the Lambda-hyperon for the nonmesonic decay Lambda N ---> N N has been determined by a measurement at COSY Juelich of the delayed fission of heavy hypernuclei produced in proton - Au collisions at T_p=1.9 GeV. It is found that heavy hypernuclei with mass numbers A= 180 +- 5 and atomic numbers Z= 74 +-2 fission with a lifetime 130ps +- 13ps (stat.) +- 15ps (syst.) . This value together with the results obtained for other heavy hypernuclei in previous investigations indicates (on the confidence level of 0.9) a violation of the phenomenological Delta I = 1/2 rule for Lambda N ---> NN transitions as known from the weak mesonic decays of kaons and hyperons. PACS: {13.30.-a}{Decays of baryons} {13.75.Ev}{Hyperon-nucleon interaction} {21.80}{Hypernuclei} {25.80.Pw}{Hyperon-induced reactions}Comment: 3 pages, 2 Postscript figures, uses svepj.clo and svjour.cls. submitted to European Physical Journal

The lifetime of the Lambda hyperon bound in hypernuclei produced by p+U collisions

The nonmesonic decay of the Lambda hyperon has been investigated by observation of delayed fission from heavy hypernuclei produced in proton-U collisions at Tp = 1.9 GeV. The lifetime of heavy hypernuclei with masses A approximately 220 obtained in the present work, i.e. tau = 138 +- 6 (stat.) +-m 17 (syst.) ps, is the most accurate result for heavy hypernuclei produced in proton and antiproton induced collisions on a U target so far. PACS: {13.30.-a}{Decays of baryons} {13.75.Ev}{Hyperon-nucleon interaction} {21.80}{Hypernuclei} {25.80.Pw}{Hyperon-induced reactions}Comment: 16 pages, 4 Postscript figures, uses file appolb.cls (included), submitted to Acta Physica Polonica B, http://th-www.if.uj.edu.pl/act

Nonmesonic decay of the Lambda hyperon in nuclear matter - implications on the weak Lambda-N interaction

The lifetime of the Lambda hyperon in heavy hypernuclei as measured by the COSY-13 Collaboration in proton - Au, Bi and U collisions has been analysed to yield tau(Lambda) = (145 +- 11) ps. This value for tau(Lambda) is compatible with the lifetime extracted from antiproton annihilation on Bi and U targets, however, much more accurate. We find that the dependence of the lifetime tau(Lambda) on the mass of hypernuclei indicates a violation of the phenomenological Delta I = 1/2 rule known from the weak mesonic decays of strange particles. PACS: {13.30.-a}{Decays of baryons} {13.75.Ev}{Hyperon-nucleon interaction} {21.80}{Hypernuclei} {25.80.Pw}{Hyperon-induced reactions}Comment: 21 pages, 11 PostScript figures, EPJA in prin

Near threshold eta meson production in the d+d->alpha+eta reaction

The d+d->alpha+eta reaction has been investigated near threshold using the ANKE facility at COSY-Juelich. Both total and differential cross sections have been measured at two excess energies, Q=2.6 MeV and 7.7 MeV, with a subthreshold measurement being undertaken at Q=-2.6 MeV to study the physical background. While consistent with isotropy at the lower energy, the angular distribution reveals a pronounced anisotropy at the higher one, indicating the presence of higher partial waves. Options for the decomposition into partial amplitudes and their consequences for determination of the s-wave eta-alpha scattering length are discussed.Comment: 8pp, fig.3 added, normalisation in eq.4.1 correcte

Medium effects in the production and pi0 gamma decay of omega-mesons in pA collisions in the GeV region

The omega-resonance production and its pi0 gamma decay in p-A reactions close to threshold is considered within the Intranuclear Cascade (INC) Model. The pi0 gamma invariant mass distribution shows two components which correspond to the omega decay 'inside' and 'outside' the nucleus, respectively. The 'inside' component is distorted by medium effects, which introduce a mass shift as well as collisional broadening for the omega-meson and its decaying pion. The relative contribution of the 'inside' component is analyzed in detail for different kinematical conditions and nuclear targets. It is demonstrated that a measurement of the correlation in azimuthal angle between the pi0 and gamma momenta allows to separate events related to the 'inside' omega decay from different sources of background when uncorrelated pi0's and gamma's are produced.Comment: 24 pages, 11 figure

Evidence of kaon nuclear and Coulomb potential effects on soft K+ production from nuclei

The ratio of forward K+ production on copper, silver and gold targets to that on carbon has been measured at proton beam energies between 1.5 and 2.3 GeV as a function of the kaon momentum p_K using the ANKE spectrometer at COSY-Juelich. The strong suppression in the ratios observed for p_K<200-250 MeV/c can be ascribed to a combination of Coulomb and nuclear repulsion in the K+A system. This opens a new way to investigate the interaction of K+-mesons in the nuclear medium. Our data are consistent with a K+A nuclear potential of V_K~20 MeV at low kaon momenta and normal nuclear density. Given the sensitivity of the data to the kaon potential, the current experimental precision might allow one to determine V_K to better than 3 MeV.Comment: 9 pages, 3 figures; changed conten

An Antibody Directed Against the Fusion Peptide of Junin Virus Envelope Glycoprotein GPC Inhibits pH-Induced Membrane Fusion

The arenavirus envelope glycoprotein (GPC) initiates infection in the host cell through pH-induced fusion of the viral and endosomal membranes. As in other class I viral fusion proteins, this process proceeds through a structural reorganization in GPC in which the ectodomain of the transmembrane fusion subunit (G2) engages the host cell membrane and subsequently refolds to form a highly stable six-helix bundle structure that brings the two membranes into apposition for fusion. Here, we describe a G2-directed monoclonal antibody, F100G5, that prevents membrane fusion by binding to an intermediate form of the protein on the fusion pathway. Inhibition of syncytium formation requires that F100G5 be present concomitant with exposure of GPC to acidic pH. We show that F100G5 recognizes neither the six-helix bundle nor the larger trimer-of-hairpins structure in the postfusion form of G2. Rather, Western blot analysis using recombinant proteins and a panel of alanine-scanning GPC mutants revealed that F100G5 binding is dependent on an invariant lysine residue (K283) near the N terminus of G2, in the so-called fusion peptide that inserts into the host cell membrane during the fusion process. The F100G5 epitope is located in the internal segment of the bipartite GPC fusion peptide, which also contains four conserved cysteine residues, raising the possibility that this fusion peptide may be highly structured. Collectively, our studies indicate that F100G5 identifies an on-path intermediate form of GPC. Binding to the transiently exposed fusion peptide may interfere with G2 insertion into the host cell membrane. Strategies to effectively target fusion peptide function in the endosome may lead to novel classes of antiviral agents

Measurement of the isospin-filtering dd -> 4He K+ K- reaction at Q=39 MeV

The total cross section for the dd -> 4He K+ K- reaction has been measured at a beam momentum of 3.7 GeV/c, corresponding to an excess energy of 39 MeV, which is the maximum possible at the Cooler Synchrotron COSY-J\"{u}lich. A deuterium cluster-jet target and the ANKE forward magnetic spectrometer, placed inside the storage ring, have been employed in this investigation. We find a total cross section of sigma(tot) < 14 pb, which brings into question the viability of investigating the dd -> 4He a0(980) reaction as a means of studying isospin violation.Comment: Five pages with three eps figure