Role of distinct natural killer cell subsets in anticancer response

Natural killer (NK) cells, the prototypic member of innate lymphoid cells, are important effectors of anticancer immune response. These cells can survey and control tumor initiation due to their capability to recognize and kill malignant cells and to regulate the adaptive immune response via cytokines and chemokines release. However, several studies have shown that tumor-infiltrating NK cells associated with advanced disease can have profound functional defects and display protumor activity. This evidence indicates that NK cell behavior undergoes crucial alterations during cancer progression. Moreover, a further level of complexity is due to the extensive heterogeneity and plasticity of these lymphocytes, implying that different NK cell subsets, endowed with specific phenotypic and functional features, may be involved and play distinct roles in the tumor context. Accordingly, many studies reported the enrichment of selective NK cell subsets within tumor tissue, whereas the underlying mechanisms are not fully elucidated. A malignant microenvironment can significantly impact NK cell activity, by recruiting specific subpopulations and/or influencing their developmental programming or the acquisition of a mature phenotype; in particular, neoplastic, stroma and immune cells, or tumor-derived factors take part in these processes. In this review, we will summarize and discuss the recently acquired knowledge on the possible contribution of distinct NK cell subsets in the control and/or progression of solid and hematological malignancies. Moreover, we will address emerging evidence regarding the role of different components of tumor microenvironment on shaping NK cell response

Scanning and data extraction from crop collecting mission documents

Poster presented at TDWG 2009, Montpellier (France). 9 - 13 Nov 2009

The Post-Newtonian Limit of f(R)-gravity in the Harmonic Gauge

A general analytic procedure is developed for the post-Newtonian limit of $f(R)$-gravity with metric approach in the Jordan frame by using the harmonic gauge condition. In a pure perturbative framework and by using the Green function method a general scheme of solutions up to $(v/c)^4$ order is shown. Considering the Taylor expansion of a generic function $f$ it is possible to parameterize the solutions by derivatives of $f$. At Newtonian order, $(v/c)^2$, all more important topics about the Gauss and Birkhoff theorem are discussed. The corrections to "standard" gravitational potential ($tt$-component of metric tensor) generated by an extended uniform mass ball-like source are calculated up to $(v/c)^4$ order. The corrections, Yukawa and oscillating-like, are found inside and outside the mass distribution. At last when the limit $f\rightarrow R$ is considered the $f(R)$-gravity converges in General Relativity at level of Lagrangian, field equations and their solutions.Comment: 16 pages, 10 figure

Growing up in the inner city: Exploring the adolescent development and acculturation of urban suicidal Latinas.

This chapter examines how adolescent development and acculturation impact suicidal behavior among Latinas living in the US inner city. After providing an overview of conceptual and empirical premises underlying immigrant youth development, acculturation, and suicidal behaviors, the article discusses cultural influences on Latina adolescents and their families. Drawing on data collected between 2005 and 2009, it then explores the various individual and interpersonal changes that Latina teens go through as a result of developmental and acculturative processes and how these changes relate to risks for suicide attempts. Based on cases that illustrate the developmental and acculturation trajectories of Latina nonattempters and attempters, the chapter suggests that acculturation to street culture shapes the suicidal behavior of Latina teens growing up in urban poverty

Treatment narratives of suicidal Latina teens

In this article, we examine the treatment narratives of Latina adolescent suicide attempters to understand their experiences undergoing care. For this study, we conducted content and thematic analysis of 68 interviews with Latina adolescent suicide attempters. Most teens who described positive experiences undergoing treatment (n = 39, 44.1%) did so when discussing outpatient mental health services (n = 30, 72.9%). Latinas felt that the providers who fostered their autonomy and connectedness helped them become active agents in their recovery. Clinicians serving suicidal Latinas must allow them to exercise agency while feeling emotionally connected to providers. To help Latinas manage their suicidality, treatments need to address the teens’ developmental needs

Aspirations of Latina adolescent suicide attempters

Parents’ aspirations and expectations are communicated to their offspring. Children internalize their parents’ aspirations and accept some of the expectations while rejecting others, all part of the developmental process and identity-consolidation. When the aspirations and expectations of youth and parents are incongruent, the outcomes in youths’ behavior can be deleterious, such as when adolescents manifest suicidal behaviors. We examined aspirations expressed by 12 Latina adolescent suicide attempters and their parents and compared them to 12 non-suicidal Latinas and parents. Qualitative analyses revealed that incongruence of aspirations between girls and their parents were greater among suicidal teens. Suicidal and non-suicidal Latinas presented contrasting aspirations: the former on gaining independence and the latter on completing their education and pursuing careers. Findings may inform developmental research and ways in which clinicians and policymakers can help Latinas achieve their own and their parents’ aspirations

Growing up in the inner city: Exploring the adolescent development and acculturation of urban suicidal Latinas.

This chapter examines how adolescent development and acculturation impact suicidal behavior among Latinas living in the US inner city. After providing an overview of conceptual and empirical premises underlying immigrant youth development, acculturation, and suicidal behaviors, the article discusses cultural influences on Latina adolescents and their families. Drawing on data collected between 2005 and 2009, it then explores the various individual and interpersonal changes that Latina teens go through as a result of developmental and acculturative processes and how these changes relate to risks for suicide attempts. Based on cases that illustrate the developmental and acculturation trajectories of Latina nonattempters and attempters, the chapter suggests that acculturation to street culture shapes the suicidal behavior of Latina teens growing up in urban poverty

Treatment narratives of suicidal Latina teens

In this article, we examine the treatment narratives of Latina adolescent suicide attempters to understand their experiences undergoing care. For this study, we conducted content and thematic analysis of 68 interviews with Latina adolescent suicide attempters. Most teens who described positive experiences undergoing treatment (n = 39, 44.1%) did so when discussing outpatient mental health services (n = 30, 72.9%). Latinas felt that the providers who fostered their autonomy and connectedness helped them become active agents in their recovery. Clinicians serving suicidal Latinas must allow them to exercise agency while feeling emotionally connected to providers. To help Latinas manage their suicidality, treatments need to address the teens’ developmental needs

Can Better Mother-Daughter Relations Reduce the Chance of a Suicide Attempt among Latinas?

National surveys and other research on adolescent Latinas show that adolescent females have higher rates of suicidal ideation, planning, and attempts than other ethnic and racial minority youth. Internalizing behaviors and family conflicts are commonly associated with suicidality in research on adolescents. In the case of Latinas, we explore the connection between adolescent Hispanic cultural involvement, mother-adolescent mutuality, internalizing behaviors, and suicidality. This paper presents data from a study of 232 Latinas, some with a recent history of suicide attempts (n = 122). The results show that higher adolescent Hispanic cultural involvement was associated with greater mother-daughter mutuality and thus led to reduction in the likelihood of suicide attempts. The relationship between mother-daughter mutuality and suicide attempts among Latinas is mediated by specific internalizing behaviors (withdrawn depressive). Our findings highlight the positive effect that Latino cultural values have in the relationship between Latina adolescent and their mothers and confirm the importance that internalizing behaviors and the mother-daughter relationship have for suicide attempters

Treatment narratives of suicidal Latina teens

In this article, we examine the treatment narratives of Latina adolescent suicide attempters to understand their experiences undergoing care. For this study, we conducted content and thematic analysis of 68 interviews with Latina adolescent suicide attempters. Most teens who described positive experiences undergoing treatment (n = 39, 44.1%) did so when discussing outpatient mental health services (n = 30, 72.9%). Latinas felt that the providers who fostered their autonomy and connectedness helped them become active agents in their recovery. Clinicians serving suicidal Latinas must allow them to exercise agency while feeling emotionally connected to providers. To help Latinas manage their suicidality, treatments need to address the teens’ developmental needs