Progression of myopathology in Kearns-Sayre syndrome

We report on the progression of myopathology by comparing two biopsies from a patient with a Kearns-Sayre-Syndrome. The first biopsy was taken in 1979 and showed 10% ragged-red fibers. Myopathic changes were slight including internal nuclei and fiber splitting in 10% of the fibers. Electron microscopy revealed typical mitochondrial abnormalities with regard to number and shape. In 1989 a second biopsy was performed for an extended analysis of mitochondrial DNA. This time less than 5% of all fibers were ragged-red. Severe myopathic changes could be detected which so far has rarely been reported in mitochondrial cytopathy

Restricted equilibrium ensembles: Exact equation of state of a model glass

We investigate the thermodynamic properties of a toy model of glasses: a hard-core lattice gas with nearest neighbor interaction in one dimension. The time-evolution is Markovian, with nearest-neighbor and next-nearest neighbor hoppings, and the transition rates are assumed to satisfy detailed balance condition, but the system is non-ergodic below a glass temperature. Below this temperature, the system is in restricted thermal equilibrium, where both the number of sectors, and the number of accessible states within a sector grow exponentially with the size of the system. Using partition functions that sum only over dynamically accessible states within a sector, and then taking a quenched average over the sectors, we determine the exact equation of state of this system.Comment: 6 pages, 2 figure

Film calibration for the Skylab/ATM S-056 X-ray telescope

The sensitometry and film calibration effort for the Skylab/ATM S-056 X-ray telescope is summarized. The apparatus and procedures used are described together with the two types of flight film used, Kodak SO-212 and SO-242. The sensitometry and processing of the flight film are discussed, and the results are presented in the form of the characteristic curves and related data. The use of copy films is also discussed

Prelude to Cycle 23: The Case for a Fast-Rising, Large Amplitude Cycle

For the common data-available interval of cycles 12 to 22, we show that annual averages of sunspot number for minimum years (R(min)) and maximum years (R(max)) and of the minimum value of the aa geomagnetic index in the vicinity of sunspot minimum (aa(min)) are consistent with the notion that each has embedded within its respective record a long-term, linear, secular increase. Extrapolating each of these fits to cycle 23, we infer that it will have R(min) = 12.7 +/- 5.7, R(max) = 176.7 +/- 61.8, and aa(min) = 21.0 +/- 5.0 (at the 95-percent level of confidence), suggesting that cycle 23 will have R(min) greater than 7.0, R(max) greater than 114.9, and aa(min) greater than 16.0 (at the 97.5-percent level of confidence). Such values imply that cycle 23 will be larger than average in size and, consequently (by the Waidmeier effect), will be a fast riser. We also infer from the R(max) and aa(min) records the existence of an even- odd cycle effect, one in which the odd-following cycle is numerically larger in value than the even-leading cycle. For cycle 23, the even-odd cycle effect suggests that R(max) greater than 157.6 and aa(min) greater than 19.0, values that were recorded for cycle 22, the even-leading cycle of the current even-odd cycle pair (cycles 22 and 23). For 1995, the annual average of the aa index measured about 22, while for sunspot number, it was about 18. Because aa(min) usually lags R(min) by 1 year (true for 8 of 11 cycles) and 1996 seems destined to be the year of R(min) for cycle 23, it may be that aa(min) will occur in 1997, although it could occur in 1996 in conjunction with R(min) (true for 3 of 11 cycles). Because of this ambiguity in determining aa(min), no formal prediction based on the correlation of R(max) against aa(min), having r = 0.90, or of R(max) against the combined effects of R(min) and aa(min)-the bivariate technique-having r = 0.99, is possible until 1997, at the earliest

Gauging the Nearness and Size of Cycle Minimum

By definition, the conventional onset for the start of a sunspot cycle is the time when smoothed sunspot number (i.e., the 12-month moving average) has decreased to its minimum value (called minimum amplitude) prior to the rise to its maximum value (called maximum amplitude) for the given sunspot cycle. On the basis (if the modern era sunspot cycles 10-22 and on the presumption that cycle 22 is a short-period cycle having a cycle length of 120 to 126 months (the observed range of short-period modern era cycles), conventional onset for cycle 23 should not occur until sometime between September 1996 and March 1997, certainly between June 1996 and June 1997, based on the 95-percent confidence level deduced from the mean and standard deviation of period for the sample of six short-pei-iod modern era cycles. Also, because the first occurrence of a new cycle, high-latitude (greater than or equal to 25 degrees) spot has always preceded conventional onset of the new cycle by at least 3 months (for the data-available interval of cycles 12-22), conventional onset for cycle 23 is not expected until about August 1996 or later, based on the first occurrence of a new cycle 23, high-latitude spot during the decline of old cycle 22 in May 1996. Although much excitement for an earlier-occurring minimum (about March 1996) for cycle 23 was voiced earlier this year, the present study shows that this exuberance is unfounded. The decline of cycle 22 continues to favor cycle 23 minimum sometime during the latter portion of 1996 to the early portion of 1997

On the Importance of Cycle Minimum in Sunspot Cycle Prediction

The characteristics of the minima between sunspot cycles are found to provide important information for predicting the amplitude and timing of the following cycle. For example, the time of the occurrence of sunspot minimum sets the length of the previous cycle, which is correlated by the amplitude-period effect to the amplitude of the next cycle, with cycles of shorter (longer) than average length usually being followed by cycles of larger (smaller) than average size (true for 16 of 21 sunspot cycles). Likewise, the size of the minimum at cycle onset is correlated with the size of the cycle's maximum amplitude, with cycles of larger (smaller) than average size minima usually being associated with larger (smaller) than average size maxima (true for 16 of 22 sunspot cycles). Also, it was found that the size of the previous cycle's minimum and maximum relates to the size of the following cycle's minimum and maximum with an even-odd cycle number dependency. The latter effect suggests that cycle 23 will have a minimum and maximum amplitude probably larger than average in size (in particular, minimum smoothed sunspot number Rm = 12.3 +/- 7.5 and maximum smoothed sunspot number RM = 198.8 +/- 36.5, at the 95-percent level of confidence), further suggesting (by the Waldmeier effect) that it will have a faster than average rise to maximum (fast-rising cycles have ascent durations of about 41 +/- 7 months). Thus, if, as expected, onset for cycle 23 will be December 1996 +/- 3 months, based on smoothed sunspot number, then the length of cycle 22 will be about 123 +/- 3 months, inferring that it is a short-period cycle and that cycle 23 maximum amplitude probably will be larger than average in size (from the amplitude-period effect), having an RM of about 133 +/- 39 (based on the usual +/- 30 percent spread that has been seen between observed and predicted values), with maximum amplitude occurrence likely sometime between July 1999 and October 2000

On Determining the Rise, Size, and Duration Classes of a Sunspot Cycle

The behavior of ascent duration, maximum amplitude, and period for cycles 1 to 21 suggests that they are not mutually independent. Analysis of the resultant three-dimensional contingency table for cycles divided according to rise time (ascent duration), size (maximum amplitude), and duration (period) yields a chi-square statistic (= 18.59) that is larger than the test statistic (= 9.49 for 4 degrees-of-freedom at the 5-percent level of significance), thereby, inferring that the null hypothesis (mutual independence) can be rejected. Analysis of individual 2 by 2 contingency tables (based on Fisher's exact test) for these parameters shows that, while ascent duration is strongly related to maximum amplitude in the negative sense (inverse correlation) - the Waldmeier effect, it also is related (marginally) to period, but in the positive sense (direct correlation). No significant (or marginally significant) correlation is found between period and maximum amplitude. Using cycle 22 as a test case, we show that by the 12th month following conventional onset, cycle 22 appeared highly likely to be a fast-rising, larger-than-average-size cycle. Because of the inferred correlation between ascent duration and period, it also seems likely that it will have a period shorter than average length