8,139 research outputs found
The influence of a biopsychosocial-based treatment approach to primary overt hypothyroidism: A protocol for a pilot study
Background
Hypothyroidism is a prevalent endocrine condition. Individuals with this disease are commonly managed through supplementation with synthetic thyroid hormone, with the aim of alleviating symptoms and restoring normal thyroid stimulating hormone levels. Generally this management strategy is effective and well tolerated. However, there is research to suggest that a significant proportion of hypothyroid sufferers are being inadequately managed. Furthermore, hypothyroid patients are more likely to have a decreased sense of well-being and more commonly experience constitutional and neuropsychiatric complaints, even with pharmacological intervention.
The current management of hypothyroidism follows a biomedical model. Little consideration has been given to a biopsychosocial approach to this condition. Within the chiropractic profession there is growing support for the use of a biopsychosocial-based intervention called Neuro-Emotional Technique (NET) for this population.
Methods/Design
A placebo-controlled, single-blinded, randomised clinical pilot-trial has been designed to assess the influence of Neuro-Emotional Technique on a population with primary overt hypothyroidism. A sample of 102 adults (≥18 years) who meet the inclusion criteria will be randomised to either a treatment group or a placebo group. Each group will receive ten treatments (NET or placebo) over a six week period, and will be monitored for six months. The primary outcome will involve the measurement of depression using the Depression, Anxiety and Stress Scale (DASS). The secondary outcome measures to be used are; serum thyroid stimulating hormone, serum free-thyroxine, serum free-triiodothyronine, serum thyroid peroxidase auto-antibodies, serum thyroglobulin auto-antibodies as well as the measurement of functional health and well-being using the Short-Form-36 Version 2. The emotional states of anxiety and stress will be measured using the DASS. Self-measurement of basal heart rate and basal temperature will also be included among the secondary outcome measures. The primary and secondary measures will be obtained at commencement, six weeks and six months. Measures of basal heart rate and basal temperature will be obtained daily for the six month trial period, with recording to commence one week prior to the intervention.
Discussion
The study will provide information on the influence of NET when added to existing management regimens in individuals with primary overt hypothyroidism
Dynamic scanning probe microscopy of adsorbed molecules on graphite
We have used a combined dynamic scanning tunneling and atomic force
microscope to study the organisation of weakly bound adsorbed molecules on a
graphite substrate. Specifically we have acquired images of islands of the
perylene derivative molecules. These weakly bound molecules may be imaged in
dynamic STM, in which the probe is oscillated above the surface. We show that
molecular resolution may be readily attained and that a similar mode of imaging
may be realised using conventional STM arrangement. We also show, using
tunnelling spectroscopy, the presence of an energy gap for the adsorbed
molecules confirming a weak molecule-substrate interaction.Comment: 11 pages, 2 figure
Sensitivity of predicted bioaerosol exposure from open windrow composting facilities to ADMS dispersion model parameters
Bioaerosols are released in elevated quantities from composting facilities and are associated with negative health effects, although dose-response relationships are not well understood, and require improved exposure classification. Dispersion modelling has great potential to improve exposure classification, but has not yet been extensively used or validated in this context. We present a sensitivity analysis of the ADMS dispersion model specific to input parameter ranges relevant to bioaerosol emissions from open windrow composting. This analysis provides an aid for model calibration by prioritising parameter adjustment and targeting independent parameter estimation. Results showed that predicted exposure was most sensitive to the wet and dry deposition modules and the majority of parameters relating to emission source characteristics, including pollutant emission velocity, source geometry and source height. This research improves understanding of the accuracy of model input data required to provide more reliable exposure predictions
Spectroscopic Survey of {\gamma} Doradus Stars I. Comprehensive atmospheric parameters and abundance analysis of {\gamma} Doradus stars
We present a spectroscopic survey of known and candidate \,Doradus
stars. The high-resolution, high signal-to-noise spectra of 52 objects were
collected by five different spectrographs. The spectral classification,
atmospheric parameters (\teff, , ), and chemical
composition of the stars were derived. The stellar spectral and luminosity
classes were found between G0-A7 and IV-V, respectively. The initial values for
\teff\ and \logg\ were determined from the photometric indices and spectral
energy distribution. Those parameters were improved by the analysis of hydrogen
lines. The final values of \teff, \logg\ and were derived from the iron
lines analysis. The \teff\ values were found between 6000\,K and 7900\,K, while
\logg\,values range from 3.8 to 4.5\,dex. Chemical abundances and
values were derived by the spectrum synthesis method. The values were
found between 5 and 240\,km\,s. The chemical abundance pattern of
\,Doradus stars were compared with the pattern of non-pulsating stars.
It turned out that there is no significant difference in abundance patterns
between these two groups. Additionally, the relations between the atmospheric
parameters and the pulsation quantities were checked. A strong correlation
between the and the pulsation periods of \,Doradus variables
was obtained. The accurate positions of the analysed stars in the H-R diagram
have been shown. Most of our objects are located inside or close to the blue
edge of the theoretical instability strip of \,Doradus.Comment: 18 pages, 13 figure
Matrix-free calcium in isolated chromaffin vesicles
Isolated secretory vesicles from bovine adrenal medulla contain 80 nmol of Ca2+ and 25 nmol
of Mg2+ per milligram of protein. As determined with a Ca2+-selective electrode, a further accumulation
of about 160 nmol of Ca2+/mg of protein can be attained upon addition of the Ca2+ ionophore A23187.
During this process protons are released from the vesicles, in exchange for Ca2+ ions, as indicated by the
decrease of the pH in the incubation medium or the release of 9-aminoacridine previously taken up by the
vesicles. Intravesicular Mg2+ is not released from the vesicles by A23 187, as determined by atomic emission
spectroscopy. In the presence of N H Q , which causes the collapse of the secretory vesicle transmembrane
proton gradient (ApH), Ca2+ uptake decreases. Under these conditions A23 187-mediated influx of Ca2+
and efflux of H+ cease at Ca2+ concentrations of about 4 pM. Below this concentration Ca2+ is even released
from the vesicles. At the Ca2+ concentration at which no net flux of ions occurs the intravesicular matrix
free Ca2+ equals the extravesicular free Ca2+. In the absence of NH4C1 we determined an intravesicular
pH of 6.2. Under these conditions the Ca2+ influx ceases around 0.15 pM. From this value and the known
pH across the vesicular membrane an intravesicular matrix free Ca2+ concentration of about 24 pM was
calculated. This is within the same order of magnitude as the concentration of free Ca2+ in the vesicles
determined in the presence of NH4C1. Calculation of the total Ca2+ present in the secretory vesicles gives
an apparent intravesicular Ca2+ concentration of 40 mM, which is a factor of lo4 higher than the free
intravesicular concentration of Ca2+. It can be concluded, therefore, that the concentration gradient of free
Ca2+ across the secretory vesicle membrane in the intact chromaffin cells is probably small, which implies
that less energy is required to accumulate and maintain Ca2+ within the vesicles than was previously
anticipated
Hard Instances of the Constrained Discrete Logarithm Problem
The discrete logarithm problem (DLP) generalizes to the constrained DLP,
where the secret exponent belongs to a set known to the attacker. The
complexity of generic algorithms for solving the constrained DLP depends on the
choice of the set. Motivated by cryptographic applications, we study sets with
succinct representation for which the constrained DLP is hard. We draw on
earlier results due to Erd\"os et al. and Schnorr, develop geometric tools such
as generalized Menelaus' theorem for proving lower bounds on the complexity of
the constrained DLP, and construct sets with succinct representation with
provable non-trivial lower bounds
Dynamics of quantum dissipation systems interacting with Fermion and Boson grand canonical bath ensembles: Hierarchical equations of motion approach
A hierarchical equations of motion formalism for a quantum dissipation system
in a grand canonical bath ensemble surrounding is constructed, on the basis of
the calculus-on-path-integral algorithm, together with the parametrization of
arbitrary non-Markovin bath that satisfies fluctuation-dissipation theorem. The
influence functionals for both the Fermion or Boson bath interaction are found
to be of the same path-integral expression as the canonical bath, assuming they
all satisfy the Gaussian statistics. However, the equation of motion formalism
are different, due to the fluctuation-dissipation theories that are distinct
and used explicitly. The implications of the present work to quantum transport
through molecular wires and electron transfer in complex molecular systems are
discussed.Comment: 12page
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HyperForest: A high performance multi-processor architecture for real-time intelligent systems
Intelligent Systems are characterized by the intensive use of computer power. The computer revolution of the last few years is what has made possible the development of the first generation of Intelligent Systems. Software for second generation Intelligent Systems will be more complex and will require more powerful computing engines in order to meet real-time constraints imposed by new robots, sensors, and applications. A multiprocessor architecture was developed that merges the advantages of message-passing and shared-memory structures: expendability and real-time compliance. The HyperForest architecture will provide an expandable real-time computing platform for computationally intensive Intelligent Systems and open the doors for the application of these systems to more complex tasks in environmental restoration and cleanup projects, flexible manufacturing systems, and DOE`s own production and disassembly activities
Ergodicity, Decisions, and Partial Information
In the simplest sequential decision problem for an ergodic stochastic process
X, at each time n a decision u_n is made as a function of past observations
X_0,...,X_{n-1}, and a loss l(u_n,X_n) is incurred. In this setting, it is
known that one may choose (under a mild integrability assumption) a decision
strategy whose pathwise time-average loss is asymptotically smaller than that
of any other strategy. The corresponding problem in the case of partial
information proves to be much more delicate, however: if the process X is not
observable, but decisions must be based on the observation of a different
process Y, the existence of pathwise optimal strategies is not guaranteed.
The aim of this paper is to exhibit connections between pathwise optimal
strategies and notions from ergodic theory. The sequential decision problem is
developed in the general setting of an ergodic dynamical system (\Omega,B,P,T)
with partial information Y\subseteq B. The existence of pathwise optimal
strategies grounded in two basic properties: the conditional ergodic theory of
the dynamical system, and the complexity of the loss function. When the loss
function is not too complex, a general sufficient condition for the existence
of pathwise optimal strategies is that the dynamical system is a conditional
K-automorphism relative to the past observations \bigvee_n T^n Y. If the
conditional ergodicity assumption is strengthened, the complexity assumption
can be weakened. Several examples demonstrate the interplay between complexity
and ergodicity, which does not arise in the case of full information. Our
results also yield a decision-theoretic characterization of weak mixing in
ergodic theory, and establish pathwise optimality of ergodic nonlinear filters.Comment: 45 page
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