1,550 research outputs found

    Canonical general relativity: Matter fields in a general linear frame

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    Building on the results of previous work, we demonstrate how matter fields are incorporated into the general linear frame approach to general relativity. When considering the Maxwell one-form field, we find that the system that leads naturally to canonical vierbein general relativity has the extrinsic curvature of the Cauchy surface represented by gravitational as well as non-gravitational degrees of freedom. Nevertheless the metric compatibility conditions are undisturbed, and this apparent derivative-coupling is seen to be an effect of working with (possibly orthonormal) linear frames. The formalism is adapted to consider a Dirac Fermion, where we find that a milder form of this apparent derivative-coupling appears.Comment: 13 pages; uses AMS-latex style file

    Recombinant human interferon alpha 2b prevents and reverses experimental pulmonary hypertension

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    Pulmonary hypertension (PH) is a progressive and fatal disease with no cure. Vascular remodeling in PH involves intraluminal growth of endothelial and smooth muscle cells, leading to obliterative vascular lesions. Cell growth in these lesions is quasi-neoplastic, with evidence of monoclonality, apoptosis resistance and cancer-like metabolic derangements. Herein we tested the effect of human interferon alpha 2b (IFNα), a pleiotropic cytokine and anti-cancer therapeutic, on the development and progression of PH in the rat SU5416/hypoxia (SUH) model and mouse hypoxia model of the disease. In both models IFNα attenuated the development of PH and reversed established PH as assessed by measuring right ventricular systolic pressure and right ventricular hypertrophy. The effect of IFNα was dependent on the type I interferon receptor (IFNAR) since mice lacking a subunit of the IFNAR were not protected by IFNα. Morphometric analysis of pulmonary aterioles from hypoxic mice or SUH rats showed that IFNα inhibited pulmonary vascular remodeling in both models and that IFNα reversed remodeling in SUH rats with established disease. Immunohistochemical staining revealed that IFNα decreased the number of PCNA and Tunel positive cells in the wall of pulmonary arterioles. In vitro, IFNα inhibited proliferation of human pulmonary artery smooth muscle cells and as well as human pulmonary artery endothelial cell proliferation and apoptosis. Together these findings demonstrate that IFNα reverses established experimental PH and provide a rationale for further exploration of the use of IFNα and other immunotherpies in PH. © 2014 Bauer et al

    Frege on the Generality of Logical Laws

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    Frege claims that the laws of logic are characterized by their “generality,” but it is hard to see how this could identify a special feature of those laws. I argue that we must understand this talk of generality in normative terms, but that what Frege says provides a normative demarcation of the logical laws only once we connect it with his thinking about truth and science. He means to be identifying the laws of logic as those that appear in every one of the scientific systems whose construction is the ultimate aim of science, and in which all truths have a place. Though an account of logic in terms of scientific systems might seem hopelessly antiquated, I argue that it is not: a basically Fregean account of the nature of logic still looks quite promising

    Adaption reveals a neural code for the visual location of orientation change

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    We apply an adaptation technique to explore the neural code for the visual location of textures defined by modulation of orientation over space. In showing that adaptation to textures modulated around one orientation shifts the perceived location of textures modulated around a different orientation, we demonstrate the existence of a neural code for the location of orientation change that generalises across orientation content. Using competitive adaptation, we characterise the neural processes underlying this code as single-opponent for orientation, that is with concentric excitatory/inhibitory receptive areas tuned to a single orientation.<br /

    How tight are the limits to land and water use? - Combined impacts of food demand and climate change

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    In the coming decades, world agricultural systems will face serious transitions. Population growth, income and lifestyle changes will lead to considerable increases in food demand. Moreover, a rising demand for renewable energy and biodiversity protection may restrict the area available for food production. On the other hand, global climate change will affect production conditions, for better or worse depending on regional conditions. In order to simulate these combined effects consistently and in a spatially explicit way, we have linked the Lund-Potsdam-Jena Dynamic Global Vegetation Model (LPJ) with a &quot;Management model of Agricultural Production and its Impact on the Environment&quot; (MAgPIE). LPJ represents the global biosphere with a spatial resolution of 0.5 degree. MAgPIE covers the most important agricultural crop and livestock production types. A prototype has been developed for one sample region. In the next stage this will be expanded to several economically relevant regions on a global scale, including international trade. The two models are coupled through a layer of productivity zones. In the paper we present the modelling approach, develop first joint scenarios and discuss selected results from the coupled modelling system

    Classical and quantum radiation from a moving charge in an expanding universe

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    We investigate photon emission from a moving particle in an expanding universe. This process is analogous to the radiation from an accelerated charge in the classical electromagnetic theory. Using the framework of quantum field theory in curved spacetime, we demonstrate that the Wentzel-Kramers-Brillouin (WKB) approximation leads to the Larmor formula for the rate of the radiation energy from a moving charge in an expanding universe. Using exactly solvable models in a radiation-dominated universe and in a Milne universe, we examine the validity of the WKB formula. It is shown that the quantum effect suppresses the radiation energy in comparison with the WKB formula.Comment: 16 pages, JCAP in pres
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