Territory, Temporality and Clustered Europeanization. IHS Political Science Series: 2006, No. 109

Non-convergence amongst the EU member states, despite a wide range of integration effects, has come to be accepted as conventional wisdom in the Europeanization debate. This paper takes issue with the stress on non-convergence and makes a case for ‘clustered Europeanization’. Clustering is promoted by two variables that have so far received little attention in Europeanization research: territory and temporality. Territory influences Europeanization through (a) ‘families of nations’ and (b) center-periphery structures in an expanding European political space. Temporality matters, in particular, through the ‘relative time of accession’, i.e. when countries joined (c) in relation to their domestic political and economic development and (d) in relation to the phase of European integration. While (a) and (c) promote intra-regional commonalities in Europeanization-related domestic variables, (b) and (d) highlight inter-regional differences in the integration experience. This regional distinctness of both domestic and integration variables, in turn, promotes clustered Europeanization

Worldline algorithms for Casimir configurations

We present improved worldline numerical algorithms for high-precision calculations of Casimir interaction energies induced by scalar-field fluctuations with Dirichlet boundary conditions for various Casimir geometries. Significant reduction of numerical cost is gained by exploiting the symmetries of the worldline ensemble in combination with those of the configurations. This facilitates high-precision calculations on standard PCs or small clusters. We illustrate our strategies using the experimentally most relevant sphere-plate and cylinder-plate configuration. We compute Casimir curvature effects for a wide parameter range, revealing the tight validity bounds of the commonly used proximity force approximation (PFA). We conclude that data analysis of future experiments aiming at a precision of 0.1% must no longer be based on the PFA. Revisiting the parallel-plate configuration, we find a mapping between the D-dimensional Casimir energy and properties of a random-chain polymer ensemble.Comment: 23 pages, 9 figure

A relative Hilbert-Mumford criterion

We generalize the classical Hilbert-Mumford criteria for GIT (semi-)stability in terms of one parameter subgroups of a linearly reductive group G over a field k, to the relative situation of an equivariant, projective morphism X -> Spec A to a noetherian k-algebra A. We also extend the classical projectivity result for GIT quotients: the induced morphism X^ss/G -> Spec A^G is projective. As an example of applications to moduli problems, we consider degenerations of Hilbert schemes of points.Comment: v4: minor correction

Sympathetic Wigner function tomography of a dark trapped ion

A protocol is provided to reconstruct the Wigner function for the motional state of a trapped ion via fluorescence detection on another ion in the same trap. This "sympathetic tomography" of a dark ion without optical transitions suitable for state measurements is based on the mapping of its motional state onto one of the collective modes of the ion pair. The quantum state of this vibrational eigenmode is subsequently measured through sideband excitation of the bright ion. Physical processes to implement the desired state transfer and read-out are derived, and the accomplishment of the scheme for different mass ratios is evaluated.Comment: 8 pages, 5 figure

Reallocation of an infinetely divisible good

We consider the problem of reallocating the total initial endowments of an infinitely divisible commodity among agents with single-peaked preferences. With the uniform reallocation rule we propose a solution which satisfies many appealing properties, describing the effect of population and endowment variations on the outcome. The central properties which are studied in this context are population monotonicity, bilateral consistency, (endowment) monotonicity and (endowment) strategy-proofness. Furthermore, the uniform reallocation rule is Pareto optimal and satisfies several equity conditions, e.g., equal-treatment and envy-freeness. We study the trade-off between properties concerning variation and properties concerning equity. Furthermore, we provide several characterizations of the uniform reallocation rule based on these properties.mathematical economics and econometrics ;

CD8 T-cell induction against vascular endothelial growth factor receptor 2 by Salmonella for vaccination purposes against a murine melanoma.

The Salmonella type III secretion system (T3SS) efficiently translocates heterologous proteins into the cytosol of eukaryotic cells. This leads to an antigen-specific CD8 T-cell induction in mice orally immunized with recombinant Salmonella. Recently, we have used Salmonella's T3SS as a prophylactic and therapeutic intervention against a murine fibrosarcoma. In this study, we constructed a recombinant Salmonella strain translocating the immunogenic H-2D(b)-specific CD8 T-cell epitope VILTNPISM (KDR2) from the murine vascular endothelial growth factor receptor 2 (VEGFR2). VEGFR2 is a member of the tyrosine protein kinase family and is upregulated on proliferating endothelial cells of the tumor vasculature. After single orogastric vaccination, we detected significant numbers of KDR2-tetramer-positive CD8 T cells in the spleens of immunized mice. The efficacy of these cytotoxic T cells was evaluated in a prophylactic setting to protect mice from challenges with B16F10 melanoma cells in a flank tumor model, and to reduce dissemination of spontaneous pulmonary melanoma metastases. Vaccinated mice revealed a reduction of angiogenesis by 62% in the solid tumor and consequently a significant decrease of tumor growth as compared to non-immunized mice. Moreover, in the lung metastasis model, immunization with recombinant Salmonella resulted in a reduction of the metastatic melanoma burden by approximately 60%