53 research outputs found

    Running away experience and psychoactive substance use among adolescents in Taiwan: multi-city street outreach survey

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    <p>Abstract</p> <p>Background</p> <p>This study aimed to examine: 1) the relationship between being a runaway and the time since the first absconding event and adolescent substance use; 2) whether different kinds of psychoactive substances have a different temporal relationship to the first absconding event; and 3) whether the various reasons for the first absconding event are associated with different risks of substance use.</p> <p>Methods</p> <p>Participants were drawn from the 2004-2006 nationwide outreach programs across 26 cities/towns in Taiwan. A total of 17,133 participants, age 12-18 years, who completed an anonymous questionnaire on their experience of running away and substances use and who were now living with their families, were included in the analysis.</p> <p>Results</p> <p>The lifetime risk of tobacco, alcohol, betel nut, and illegal drug/inhalant use increased steadily from adolescents who had experienced a trial runaway episode (one time lasting ≤ 1 day), to those with extended runaway experience (≥ 2 times or lasting > 1 day), when compared to those who had never ran away. Adolescents who had their first running away experience > 6 months previously had a greater risk of betel nut or illegal drug/inhalant use over the past 6-months than those with a similar experience within the last 6 months. Both alcohol and tobacco use were most frequently initiated before the first running away, whereas both betel nut and illegal drug/inhalant use were most frequently initiated after this event. When adolescents who were fleeing an unsatisfactory home life were compared to those who ran away for excitement, the risk of alcohol use was similar but the former tended to have a higher risk of tobacco, betel nut, and illegal drug/inhalant use.</p> <p>Conclusions</p> <p>More significant running away and a longer time since the first absconding experience were associated with more advanced substance involvement among adolescents now living in a family setting. Once adolescents had left home, they developed additional psychoactive substance problems, regardless of their reasons for running away. These findings have implications for caregivers, teachers, and healthcare workers when trying to prevent and/or intervening in adolescent substance use.</p

    The Synaptonemal Complex Protein Zip1 Promotes Bi-Orientation of Centromeres at Meiosis I

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    In meiosis I, homologous chromosomes become paired and then separate from one another to opposite poles of the spindle. In humans, errors in this process are a leading cause of birth defects, mental retardation, and infertility. In most organisms, crossing-over, or exchange, between the homologous partners provides a link that promotes their proper, bipolar, attachment to the spindle. Attachment of both partners to the same pole can sometimes be corrected during a delay that is triggered by the spindle checkpoint. Studies of non-exchange chromosomes have shown that centromere pairing serves as an alternative to exchange by orienting the centromeres for proper microtubule attachment. Here, we demonstrate a new role for the synaptonemal complex protein Zip1. Zip1 localizes to the centromeres of non-exchange chromosomes in pachytene and mediates centromere pairing and segregation of the partners at meiosis I. Exchange chromosomes were also found to experience Zip1-dependent pairing at their centromeres. Zip1 was found to persist at centromeres, after synaptonemal complex disassembly, remaining there until microtubule attachment. Disruption of this centromere pairing, in spindle checkpoint mutants, randomized the segregation of exchange chromosomes. These results demonstrate that Zip1-mediated pairing of exchange chromosome centromeres promotes an initial, bipolar attachment of microtubules. This activity of Zip1 lessens the load on the spindle checkpoint, greatly reducing the chance that the cell will exit the checkpoint delay with an improperly oriented chromosome pair. Thus exchange, the spindle checkpoint, and centromere pairing are complementary mechanisms that ensure the proper segregation of homologous partners at meiosis I

    Party identification and party closeness in comparative perspective

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    The present analysis uses data from 1974 and 1981 U. S. cross sections, which incorporate a panel, to compare the standard NES measure of party identification (ID) with a measure of partisanship derived from a party closeness question widely employed in cross-national research. Important features of the two scales are examined by transforming the closeness measure into a scale of very close, fairly close, not very close, and no preference corresponding to the seven-point ID scale. The scales are highly correlated and are similar in their reliability. More than 75% of the “independents” in the ID scale choose a party in the closeness version, and over half of these select the “fairly close” category. Respondents do not volunteer that they are independents when that alternative is not stated in the question.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45482/1/11109_2004_Article_BF00990552.pd

    Strategic Adaptive Governance and Climate Change: Policymaking during Extreme Political Upheaval

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    Adaptive governance seeks to address complicated and difficult policy problems. Due to the extreme political upheaval wrought by the Trump administration’s dismantling of federal climate change programs, many state and local governments are considering new policy approaches. Yet by ignoring crucial aspects of politics and intergovernmental relations, the adaptive governance literature provides little guidance for such substantial issues. This paper introduces the concept of strategic adaptive governance, a framework for permitting policymakers to achieve the highest rate of compliance possible under existing conditions and constraints involving state and local policy, despite political upheaval. The strategic adaptive governance model embraces politics, accounts for the role of central authorities, and emphasizes the motivations, resources, and interdependencies of affected parties. We apply the model in an analysis of California’s Global Warming Solutions Act of 2006 (AB 32), examining the extent to which it aligns with strategic adaptive governance, and evaluating the potential for the state to utilize the model. We find that AB 32 aligns moderately with strategic adaptive governance, and discuss how the model could help protect and enhance policy gains. More broadly, strategic adaptive governance provides a generic and universal framework for policymakers interested in tactical formulation of any regulatory policy
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