Essential Nutrients for Bone Health and a Review of their Availability in the Average North American Diet

Osteoporosis and low bone mineral density affect millions of Americans. The majority of adults in North America have insufficient intake of vitamin D and calcium along with inadequate exercise. Physicians are aware that vitamin D, calcium and exercise are essential for maintenance of bone health. Physicians are less likely to be aware that dietary insufficiencies of magnesium, silicon, Vitamin K, and boron are also widely prevalent, and each of these essential nutrients is an important contributor to bone health. In addition, specific nutritional factors may improve calcium metabolism and bone formation. It is the authors’ opinion that nutritional supplements should attempt to provide ample, but not excessive, amounts of factors that are frequently insufficient in the typical American diet

Dichlorobis[1-(2-ethoxyethyl)-1H-benzimidazole-?3] cobalt(II)

The title compound, [CoCl2(C11H14N 2O)2], was synthesized from 1-(2-ethoxyethyl)benzimidazole and cobalt dichloride in ethanol. The CoII atom is coordinated in a distorted tetrahedral environment by two Cl atoms and two N atoms. The crystal structure is stabilized by intermolecular C - H?Cl and C - H?O interactions. © 2004 International Union of Crystallography Printed in Great Britain - all rights reserved

Synthesis and antimicrobial activities of some transition metal benzimidazole complexes

The interaction of N-monosubstituted benzimidazoles with various metal salts [CoCl2, NiCl2 and Zn(OAc)2)] were yielded stable solid metal benzimidazole complexes. All the metal complexes were identified by 1H NMR, FT-IR spectroscopic techniques, elemental analysis and screened for their in vitro antimicrobial activities against the standard strains: Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and yeasts Candida albicans and Candida tropicalis. Some of the compounds inhibited the growth of grampositive bacteria (E. faecalis and S. aureus) at MIC values between 200 and 800 µg/mL. None of the compounds exhibit antimicrobial activity against gram-negative bacteria (E. coli and P. aeruginosa) at the concentrations studied (6.25-800 µg/mL). Some of the tested compounds exhibit an antifungal activity with a range of the MICs between 100 and 800 µg/mL

1-Benzyl-3-(2-phenethyl)benzimidazolium bromide monohydrate

The title compound, C22H20N2 +·Br-·H2O, was synthesized from 1-benzylbenzimidazole and 2-bromoethylbenzene in dimethylformamide. The dihedral angle between the two phenyl rings is 70.6 (1)°. These phenyl rings make dihedral angles of 52.99 (9) and 83.03 (8)° with the benzimidazole ring system. The crystal structure is stabilized by intermolecular C-H?Br and O-H?Br hydrogen-bond interactions. © 2005 International Union of Crystallography Printed in Great Britain - all rights reserved

1-methoxyethyl-5-nitrobenzimidazole

The title compound, C10H11N3O3, was synthesized by the reaction of 5-nitrobenzimidazole, 2-chloroethyl methyl ether and KOH in ethanol. The bond lengths and angles are unexceptional. © 2005 International Union of Crystallography Printed in Great Britain - all rights reserved