22,286 research outputs found
Surface immobilization of hexa-histidine-tagged adeno-associated viral vectors for localized gene delivery.
Adeno-associated viral (AAV) vectors, which are undergoing broad exploration in clinical trials, have significant promise for therapeutic gene delivery because of their safety and delivery efficiency. Gene delivery technologies capable of mediating localized gene expression may further enhance the potential of AAV in a variety of therapeutic applications by reducing spread outside a target region, which may thereby reduce off-target side effects. We have genetically engineered an AAV variant capable of binding to surfaces with high affinity through a hexa-histidine metal-binding interaction. This immobilized AAV vector system mediates high-efficiency delivery to cells that contact the surface and thus may have promise for localized gene delivery, which may aid numerous applications of AAV delivery to gene therapy
Putative spin liquid in the triangle-based iridate BaIrTiO
We report on thermodynamic, magnetization, and muon spin relaxation
measurements of the strong spin-orbit coupled iridate BaIrTiO,
which constitutes a new frustration motif made up a mixture of edge- and
corner-sharing triangles. In spite of strong antiferromagnetic exchange
interaction of the order of 100~K, we find no hint for long-range magnetic
order down to 23 mK. The magnetic specific heat data unveil the -linear and
-squared dependences at low temperatures below 1~K. At the respective
temperatures, the zero-field muon spin relaxation features a persistent spin
dynamics, indicative of unconventional low-energy excitations. A comparison to
the isostructural compound BaRuTiO suggests that a concerted
interplay of compass-like magnetic interactions and frustrated geometry
promotes a dynamically fluctuating state in a triangle-based iridate.Comment: Physical Review B accepte
Production and optical properties of liquid scintillator for the JSNS experiment
The JSNS (J-PARC Sterile Neutrino Search at J-PARC Spallation Neutron
Source) experiment will search for neutrino oscillations over a 24 m short
baseline at J-PARC. The JSNS inner detector will be filled with 17 tons
of gadolinium-loaded liquid scintillator (LS) with an additional 31 tons of
unloaded LS in the intermediate -catcher and outer veto volumes.
JSNS has chosen Linear Alkyl Benzene (LAB) as an organic solvent because
of its chemical properties. The unloaded LS was produced at a refurbished
facility, originally used for scintillator production by the RENO experiment.
JSNS plans to use ISO tanks for the storage and transportation of the LS.
In this paper, we describe the LS production, and present measurements of its
optical properties and long term stability. Our measurements show that storing
the LS in ISO tanks does not result in degradation of its optical properties.Comment: 7 pages, 4 figures
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