Noise of high-Tc superconducting films and bolometers

The results of the noise investigations of high-Tc superconducting films (HTS) and bolometers are reported. HTS films produced by the magnetron and laser depositions on various substrates were studied. Structural, excess noise and critical current properties were investigated Noise measurements of antenna YBa2Cu3O7-x microbolometer on NdGaO3 substrate and GdBa2Cu3O7-x bolometer on Si-membrane showed that the noise parameters of bolometers were limited by only the phonon noise at operating frequency

Pathways for Holliday Junction Processing during Homologous Recombination in Saccharomyces cerevisiae ▿

The Saccharomyces cerevisiae Rmi1 protein is a component of the highly conserved Sgs1-Top3-Rmi1 complex. Deletion of SGS1, TOP3, or RMI1 is synthetically lethal when combined with the loss of the Mus81-Mms4 or Slx1-Slx4 endonucleases, which have been implicated in Holliday junction (HJ) resolution. To investigate the causes of this synthetic lethality, we isolated a temperature-sensitive mutant of the RMI1 strain, referred to as the rmi1-1 mutant. At the restrictive temperature, this mutant phenocopies an rmi1Δ strain but behaves like the wild type at the permissive temperature. Following a transient exposure to methyl methanesulfonate, rmi1-1 mutants accumulate unprocessed homologous recombination repair (HRR) intermediates. These intermediates are slowly resolved at the restrictive temperature, revealing a redundant resolution activity when Rmi1 is impaired. This resolution depends on Mus81-Mms4 but not on either Slx1-Slx4 or another HJ resolvase, Yen1. Similar results were also observed when Top3 function was impaired. We propose that the Sgs1-Top3-Rmi1 complex constitutes the main pathway for the processing of HJ-containing HRR intermediates but that Mus81-Mms4 can also resolve these intermediates