1,284 research outputs found
Magneto-elastic coupling and competing entropy changes in substituted CoMnSi metamagnets
We use neutron diffraction, magnetometry and low temperature heat capacity to
probe giant magneto-elastic coupling in CoMnSi-based antiferromagnets and to
establish the origin of the entropy change that occurs at the metamagnetic
transition in such compounds. We find a large difference between the electronic
density of states of the antiferromagnetic and high magnetisation states. The
magnetic field-induced entropy change is composed of this contribution and a
significant counteracting lattice component, deduced from the presence of
negative magnetostriction. In calculating the electronic entropy change, we
note the importance of using an accurate model of the electronic density of
states, which here varies rapidly close to the Fermi energy.Comment: 11 pages, 9 figures. Figures 4 and 6 were updated in v2 of this
preprint. In v3, figures 1 and 2 have been updated, while Table II and the
abstract have been extended. In v4, Table I has updated with relevant neutron
diffraction dat
Landauer Theory, Inelastic Scattering and Electron Transport in Molecular Wires
In this paper we address the topic of inelastic electron scattering in
mesoscopic quantum transport. For systems where only elastic scattering is
present, Landauer theory provides an adequate description of transport that
relates the electronic current to single-particle transmission and reflection
probabilities. A formalism proposed recently by Bonca and Trugman facilitates
the calculation of the one-electron transmission and reflection probabilities
for inelastic processes in mesoscopic conductors connected to one-dimensional
ideal leads. Building on their work, we have developed a self-consistent
procedure for the evaluation of the non-equilibrium electron distributions in
ideal leads connecting such mesoscopic conductors to electron reservoirs at
finite temperatures and voltages. We evaluate the net electronic current
flowing through the mesoscopic device by utilizing these non-equilibrium
distributions. Our approach is a generalization of Landauer theory that takes
account of the Pauli exclusion principle for the various competing elastic and
inelastic processes while satisfying the requirement of particle conservation.
As an application we examine the influence of elastic and inelastic scattering
on conduction through a two site molecular wire with longitudinal phonons using
the Su-Schrieffer-Heeger model of electron-phonon coupling.Comment: 25 pages, 8 figure
Evaluation of range of motion restriction within the hip joint
In Total Hip Arthroplasty, determining the impingement free range of motion requirement is a complex task. This is because in the native hip, motion is restricted by both impingement as well as soft tissue restraint. The aim of this study is to determine a range of motion benchmark which can identify motions which are at risk from impingement and those which are constrained due to soft tissue. Two experimental methodologies were used to determine motions which were limited by impingement and those motions which were limited by both impingement and soft tissue restraint. By comparing these two experimental results, motions which were limited by impingement were able to be separated from those motions which were limited by soft tissue restraint. The results show motions in extension as well as flexion combined with adduction are limited by soft tissue restraint. Motions in flexion, flexion combined with abduction and adduction are at risk from osseous impingement. Consequently, these motions represent where the maximum likely damage will occur in femoroacetabular impingement or at most risk of prosthetic impingement in Total Hip Arthroplasty
Tuning a Resonance in the Fock Space: Optimization of Phonon Emission in a Resonant Tunneling Device
Phonon-assisted tunneling in a double barrier resonant tunneling device can
be seen as a resonance in the electron-phonon Fock space which is tuned by the
applied voltage. We show that the geometrical parameters can induce a symmetry
condition in this space that can strongly enhance the emission of longitudinal
optical phonons. For devices with thin emitter barriers this is achieved by a
wider collector's barrier.Comment: 4 pages, 3 figures. Figure 1 changed, typos correcte
Fermi liquid to Luttinger liquid transition at the edge of a two-dimensional electron gas
We present experimental results on the tunneling into the edge of a two
dimensional electron gas (2DEG) obtained with a GaAs/AlGaAs cleaved edge
overgrown structure in a strong perpendicular magnetic field. While the 2DEG
exhibits typical fractional quantum Hall features of a very high mobility
sample, we observe the onset of a non-linear current-voltage characteristic in
the vicinity of nu=1. For filling factor nu<1 the system is consistent with a
non-Fermi liquid behavior, such as a Luttinger liquid, whereas for nu>1 we
observe an Ohmic tunneling resistance between the edge and a three dimensional
contact, typical for a Fermi liquid. Hence, at the edge, there is a transition
from a Luttinger liquid to a Fermi liquid. Finally, we show that the Luttinger
liquid exponent at a given filling factor is not universal but depends on
sample parameters.Comment: 4 pages, 4 figure
ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer.
Trastuzumab prolongs survival in HER2 positive breast cancer patients. However, resistance remains a challenge. We have previously shown that ADAM17 plays a key role in maintaining HER2 phosphorylation during trastuzumab treatment. Beside ADAM17, ADAM10 is the other well characterized ADAM protease responsible for HER ligand shedding. Therefore, we studied the role of ADAM10 in relation to trastuzumab treatment and resistance in HER2 positive breast cancer. ADAM10 expression was assessed in HER2 positive breast cancer cell lines and xenograft mice treated with trastuzumab. Trastuzumab treatment increased ADAM10 levels in HER2 positive breast cancer cells (p ≤ 0.001 in BT474; p ≤ 0.01 in SKBR3) and in vivo (p ≤ 0.0001) compared to control, correlating with a decrease in PKB phosphorylation. ADAM10 inhibition or knockdown enhanced trastuzumab response in naïve and trastuzumab resistant breast cancer cells. Trastuzumab monotherapy upregulated ADAM10 (p ≤ 0.05); and higher pre-treatment ADAM10 levels correlated with decreased clinical response (p ≤ 0.05) at day 21 in HER2 positive breast cancer patients undergoing a trastuzumab treatment window study. Higher ADAM10 levels correlated with poorer relapse-free survival (p ≤ 0.01) in a cohort of HER2 positive breast cancer patients. Our studies implicate a role of ADAM10 in acquired resistance to trastuzumab and establish ADAM10 as a therapeutic target and a potential biomarker for HER2 positive breast cancer patients
Effect of femoral neck modularity upon the prosthetic range of motion in total hip arthroplasty
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Erratum: Consortium biology in immunology: The perspective from the Immunological Genome Project
Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants
Background: Underweight and severe and morbid obesity are associated with highly elevated risks of adverse health outcomes. We estimated trends in mean body-mass index (BMI), which characterises its population distribution, and in the prevalences of a complete set of BMI categories for adults in all countries.
Methods: We analysed, with use of a consistent protocol, population based studies that had measured height and weight in adults aged 18 years and older. We applied a Bayesian hierarchical model to these data to estimate trends from 1975 to 2014 in mean BMI and in the prevalences of BMI categories (<18·5 kg/m² [underweight], 18·5 kg/m² to <20 kg/m², 20 kg/m² to <25 kg/m², 25 kg/m² to <30 kg/m², 30 kg/m² to <35 kg/m², 35 kg/m² to <40 kg/m², =40 kg/m² [morbid obesity]), by sex in 200 countries and territories, organised in 21 regions. We calculated the posterior probability of meeting the target of halting by 2025 the rise in obesity at its 2010 levels, if post-2000 trends continue.
Findings: We used 1698 population-based data sources, with more than 19·2 million adult participants (9·9 million men and 9·3 million women) in 186 of 200 countries for which estimates were made. Global age-standardised mean BMI increased from 21·7 kg/m² (95% credible interval 21·3–22·1) in 1975 to 24·2 kg/m² (24·0–24·4) in 2014 in men, and from 22·1 kg/m² (21·7–22·5) in 1975 to 24·4 kg/m² (24·2–24·6) in 2014 in women. Regional mean BMIs in 2014 for men ranged from 21·4 kg/m² in central Africa and south Asia to 29·2 kg/m² (28·6–29·8) in Polynesia and Micronesia; for women the range was from 21·8 kg/m² (21·4–22·3) in south Asia to 32·2 kg/m² (31·5–32·8) in Polynesia and Micronesia. Over these four decades, age-standardised global prevalence of underweight decreased from 13·8% (10·5–17·4) to 8·8% (7·4–10·3) in men and from 14·6% (11·6–17·9) to 9·7% (8·3–11·1) in women. South Asia had the highest prevalence of underweight in 2014, 23·4% (17·8–29·2) in men and 24·0% (18·9–29·3) in women. Age-standardised prevalence of obesity increased from 3·2% (2·4–4·1) in 1975 to 10·8% (9·7–12·0) in 2014 in men, and from 6·4% (5·1–7·8) to 14·9% (13·6–16·1) in women. 2·3% (2·0–2·7) of the world’s men and 5·0% (4·4–5·6) of women were severely obese (ie, have BMI =35 kg/m²). Globally, prevalence of morbid obesity was 0·64% (0·46–0·86) in men and 1·6% (1·3–1·9) in women.
Interpretation: If post-2000 trends continue, the probability of meeting the global obesity target is virtually zero. Rather, if these trends continue, by 2025, global obesity prevalence will reach 18% in men and surpass 21% in women; severe obesity will surpass 6% in men and 9% in women. Nonetheless, underweight remains prevalent in the world’s poorest regions, especially in south Asia
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