Supporting development and management of smart office applications: a DYAMAND case study

To realize the Internet of Things (IoT) vision, tools are needed to ease the development and deployment of practical applications. Several standard bodies, companies, and ad-hoc consortia are proposing their own solution for inter-device communication. In this context, DYnamic, Adaptive MAnagement of Networks and Devices (DYAMAND) was presented in a previous publication to solve the interoperability issues introduced by the multitude of available technologies. In this paper a DYAMAND case study is presented: in cooperation with a large company, a monitoring application was developed for flexible office spaces in order to reliably reorganize an office environment and give real-time feedback on the usage of meeting rooms. Three wireless sensor technologies were investigated to be used in the pilot. The solution was deployed in a "friendly user" setting at a research institute (iMinds) prior to deployment at the large company's premises. Based on the findings of both installations, requirements for an application platform supporting development and management of smart (office) applications were listed. DYAMAND was used as the basis of the implementation. Although the local management of networked devices as provided by DYAMAND enables easier development of intelligent applications, a number of remote services discussed in this paper are needed to enable reliable and up-to-date support (of new technologies)

Regulatory effects of post-translational modifications on zDHHC S-acyltransferases

The human zDHHC S-acyltransferase family comprises 23 enzymes that mediate the S-acylation of a multitude of cellular proteins, including channels, receptors, transporters, signaling molecules, scaffolds, and chaperones. This reversible post-transitional modification (PTM) involves the attachment of a fatty acyl chain, usually derived from palmitoyl-CoA, to specific cysteine residues on target proteins, which affects their stability, localization, and function. These outcomes are essential to control many processes, including synaptic transmission and plasticity, cell growth and differentiation, and infectivity of viruses and other pathogens. Given the physiological importance of S-acylation, it is unsurprising that perturbations in this process, including mutations in ZDHHC genes, have been linked to different neurological pathologies and cancers, and there is growing interest in zDHHC enzymes as novel drug targets. Although zDHHC enzymes control a diverse array of cellular processes and are associated with major disorders, our understanding of these enzymes is surprisingly incomplete, particularly with regard to the regulatory mechanisms controlling these enzymes. However, there is growing evidence highlighting the role of different PTMs in this process. In this review, we discuss how PTMs, including phosphorylation, S-acylation, and ubiquitination, affect the stability, localization, and function of zDHHC enzymes and speculate on possible effects of PTMs that have emerged from larger screening studies. Developing a better understanding of the regulatory effects of PTMs on zDHHC enzymes will provide new insight into the intracellular dynamics of S-acylation and may also highlight novel approaches to modulate S-acylation for clinical gain

Universal measurement apparatus controlled by quantum software

We propose a quantum device that can approximate any projective measurement on a qubit. The desired measurement basis is selected by the quantum state of a "program register". The device is optimized with respect to maximal average fidelity (assuming uniform distribution of measurement bases). An interesting result is that if one uses two qubits in the same state as a program the average fidelity is higher than if he/she takes the second program qubit in the orthogonal state (with respect to the first one). The average information obtainable by the proposed measurements is also calculated and it is shown that it can get different values even if the average fidelity stays constant. Possible experimental realization of the simplest proposed device is presented.Comment: 4 pages, 2 figures, reference adde

Purification and detection of entangled coherent states

In [J. C. Howell and J. A. Yeazell, Phys. Rev. A 62, 012102 (2000)], a proposal is made to generate entangled macroscopically distinguishable states of two spatially separated traveling optical modes. We model the decoherence due to light scattering during the propagation along an optical transmission line and propose a setup allowing an entanglement purification from a number of preparations which are partially decohered due to transmission. A purification is achieved even without any manual intervention. We consider a nondemolition configuration to measure the purity of the state as contrast of interference fringes in a double-slit setup. Regarding the entangled coherent states as a state of a bipartite quantum system, a close relationship between purity and entanglement of formation can be obtained. In this way, the contrast of interference fringes provides a direct means to measure entanglement.Comment: 9 pages, 6 figures, using Revtex

Homodyne locking of a squeezer

We report on the successful implementation of a new approach to locking the frequencies of an OPO-based squeezed-vacuum source and its driving laser. The technique allows the simultaneous measurement of the phase-shifts induced by a cavity, which may be used for the purposes of frequency-locking, as well as the simultaneous measurement of the sub-quantum-noise-limited (sub-QNL) phase quadrature output of the OPO. The homodyne locking technique is cheap, easy to implement and has the distinct advantage that subsequent homodyne measurements are automatically phase-locked. The homodyne locking technique is also unique in that it is a sub-QNL frequency discriminator.Comment: Accepted to Optics Letter