11,901 research outputs found

    The alphaviruses: gene expression, replication, and evolution

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    The alphaviruses are a genus of 26 enveloped viruses that cause disease in humans and domestic animals. Mosquitoes or other hematophagous arthropods serve as vectors for these viruses. The complete sequences of the +/- 11.7-kb plus-strand RNA genomes of eight alphaviruses have been determined, and partial sequences are known for several others; this has made possible evolutionary comparisons between different alphaviruses as well as comparisons of this group of viruses with other animal and plant viruses. Full-length cDNA clones from which infectious RNA can be recovered have been constructed for four alphaviruses; these clones have facilitated many molecular genetic studies as well as the development of these viruses as expression vectors. From these and studies involving biochemical approaches, many details of the replication cycle of the alphaviruses are known. The interactions of the viruses with host cells and host organisms have been exclusively studied, and the molecular basis of virulence and recovery from viral infection have been addressed in a large number of recent papers. The structure of the viruses has been determined to about 2.5 nm, making them the best-characterized enveloped virus to date. Because of the wealth of data that has appeared, these viruses represent a well-characterized system that tell us much about the evolution of RNA viruses, their replication, and their interactions with their hosts. This review summarizes our current knowledge of this group of viruses

    Auditory pontine grey

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    Housing production subsidies and neighborhood revitalization: New York City's ten-year capital plan for housing

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    This paper was presented at the conference "Policies to Promote Affordable Housing," cosponsored by the Federal Reserve Bank of New York and New York University's Furman Center for Real Estate and Urban Policy, February 7, 2002. It was part of Session 3: The Impact of Housing on People and Places.Housing - New York (N.Y.) ; Construction industry - New York (N.Y.) ; Housing subsidies ; Federal Reserve District, 2nd ; Housing - Finance

    The Weak Field Limit of the Magnetorotational Instability

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    We investigate the behavior of the magneto-rotational instability in the limit of extremely weak magnetic field, i.e., as the ratio of ion cyclotron frequency to orbital frequency (X) becomes small. Considered only in terms of cold two-fluid theory, instability persists to arbitrarily small values of X, and the maximum growth rate is of order the orbital frequency except for the range m_e/m_i < |X| < 1, where it can be rather smaller. In this range, field aligned with rotation (X > 0) produces slower growth than anti-aligned field (X < 0). The maximum growth rate is generally achieved at smaller and smaller wavelengths as |X| diminishes. When |X| < m_e/m_i, new unstable "electromagnetic-rotational" modes appear that do not depend on the equilibrium magnetic field. Because the most rapidly-growing modes have extremely short wavelengths when |X| is small, they are often subject to viscous or resistive damping, which can result in suppressing all but the longest wavelengths, for which growth is much slower. We find that this sort of damping is likely to curtail severely the frequently-invoked mechanism for cosmological magnetic field growth in which a magnetic field seeded by the Biermann battery is then amplified by the magneto-rotational instability. On the other hand, the small |X| case may introduce interesting effects in weakly-ionized disks in which dust grains carry most of the electric charge.Comment: 30 pages, including 4 figures; revised version resubmitted to Ap
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