5,012 research outputs found
The Early Bird Catches The Term: Combining Twitter and News Data For Event Detection and Situational Awareness
Twitter updates now represent an enormous stream of information originating
from a wide variety of formal and informal sources, much of which is relevant
to real-world events. In this paper we adapt existing bio-surveillance
algorithms to detect localised spikes in Twitter activity corresponding to real
events with a high level of confidence. We then develop a methodology to
automatically summarise these events, both by providing the tweets which fully
describe the event and by linking to highly relevant news articles. We apply
our methods to outbreaks of illness and events strongly affecting sentiment. In
both case studies we are able to detect events verifiable by third party
sources and produce high quality summaries
Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice
Activating signal cointegrator 2 (ASC-2), a cancer-amplified transcriptional coactivator of nuclear receptors and many other transcription factors, contains two LXXLL-type nuclear receptor interaction domains. Interestingly, the second LXXLL motif is highly specific to the liver X receptors (LXRs). In cotransfection, DN2, an ASC-2 fragment encompassing this motif, exerts a potent dominant-negative effect on transactivation by LXRs, which is rescued by ectopic coexpression of the full-length ASC-2 but not by other LXXLL-type coactivators, such as SRC-1 and TRAP220. In contrast, DN2/m, in which the LXXLL motif is mutated to LXXAA to abolish the interactions with LXRs, is without any effect. Accordingly, expression of DN2, but not DN2/m, in transgenic mice results in phenotypes that are highly homologous to those previously observed with LXRalpha(-/-) mice, including a rapid accumulation of large amounts of cholesterol and down-regulation of the known lipid-metabolizing target genes of LXRalpha in the liver upon being fed a high-cholesterol diet. These results identify ASC-2 as a physiologically important transcriptional coactivator of LXRs and demonstrate its pivotal role in the liver lipid metabolism.open1136sciescopu
Cyclotron effective masses in layered metals
Many layered metals such as quasi-two-dimensional organic molecular crystals
show properties consistent with a Fermi liquid description at low temperatures.
The effective masses extracted from the temperature dependence of the magnetic
oscillations observed in these materials are in the range, m^*_c/m_e \sim 1-7,
suggesting that these systems are strongly correlated. However, the ratio
m^*_c/m_e contains both the renormalization due to the electron-electron
interaction and the periodic potential of the lattice. We show that for any
quasi-two-dimensional band structure, the cyclotron mass is proportional to the
density of states at the Fermi energy. Due to Luttinger's theorem, this result
is also valid in the presence of interactions. We then evaluate m_c for several
model band structures for the \beta, \kappa, and \theta families of
(BEDT-TTF)_2X, where BEDT-TTF is bis-(ethylenedithia-tetrathiafulvalene) and X
is an anion. We find that for \kappa-(BEDT-TTF)_2X, the cyclotron mass of the
\beta-orbit, m^{*\beta}_c, is close to 2 m^{*\alpha}_c, where m^{*\alpha}_c is
the effective mass of the \alpha- orbit. This result is fairly insensitive to
the band structure details. For a wide range of materials we compare values of
the cyclotron mass deduced from band structure calculations to values deduced
from measurements of magnetic oscillations and the specific heat coefficient.Comment: 12 pages, 3 eps figure
First Observation of a Stable Highly Dissipative Divertor Plasma Regime on the Wendelstein 7-X Stellarator
Unusual low-temperature thermopower in the one-dimensional Hubbard model
The low-temperature thermoelectric power of the repulsive-interaction
one-dimensional Hubbard model is calculated using an asymptotic Bethe ansatz
for holons and spinons. The competition between the entropy carried by the
holons and that carried by the backflow of the spinons gives rise to an unusual
temperature and doping dependence of the thermopower which is qualitatively
similar to that observed in the normal state of high- superconductors.Comment: 11 pages, REVTEX 3.
The alignment of molecular cloud magnetic fields with the spiral arms in M33
The formation of molecular clouds, which serve as stellar nurseries in
galaxies, is poorly understood. A class of cloud formation models suggests that
a large-scale galactic magnetic field is irrelevant at the scale of individual
clouds, because the turbulence and rotation of a cloud may randomize the
orientation of its magnetic field. Alternatively, galactic fields could be
strong enough to impose their direction upon individual clouds, thereby
regulating cloud accumulation and fragmentation, and affecting the rate and
efficiency of star formation. Our location in the disk of the Galaxy makes an
assessment of the situation difficult. Here we report observations of the
magnetic field orientation of six giant molecular cloud complexes in the
nearby, almost face-on, galaxy M33. The fields are aligned with the spiral
arms, suggesting that the large-scale field in M33 anchors the clouds.Comment: to appear in Natur
Thermodynamic theory of epitaxial ferroelectric thin films with dense domain structures
A Landau-Ginsburg-Devonshire-type nonlinear phenomenological theory is
presented, which enables the thermodynamic description of dense laminar
polydomain states in epitaxial ferroelectric thin films. The theory explicitly
takes into account the mechanical substrate effect on the polarizations and
lattice strains in dissimilar elastic domains (twins). Numerical calculations
are performed for PbTiO3 and BaTiO3 films grown on (001)-oriented cubic
substrates. The "misfit strain-temperature" phase diagrams are developed for
these films, showing stability ranges of various possible polydomain and
single-domain states. Three types of polarization instabilities are revealed
for polydomain epitaxial ferroelectric films, which may lead to the formation
of new polydomain states forbidden in bulk crystals. The total dielectric and
piezoelectric small-signal responses of polydomain films are calculated,
resulting from both the volume and domain-wall contributions. For BaTiO3 films,
strong dielectric anomalies are predicted at room temperature near special
values of the misfit strain.Comment: 19 pages, 8 figure
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