1,294 research outputs found
HST/ACS Images of the GG Tauri Circumbinary Disk
Hubble Space Telescope Advanced Camera for Surveys images of the young binary
GG Tauri and its circumbinary disk in V and I bandpasses were obtained in 2002
and are the most detailed of this system to date. The confirm features
previously seen in the disk including: a "gap" apparently caused by shadowing
from circumstellar material; an asymmetrical distribution of light about the
line of sight on the near edge of the disk; enhanced brightness along the near
edge of the disk due to forward scattering; and a compact reflection nebula
near the secondary star. New features are seen in the ACS images: two short
filaments along the disk; localized but strong variations in disk intensity
("gaplets"); and a "spur" or filament extending from the reflection nebulosity
near the secondary. The back side of the disk is detected in the V band for the
first time. The disk appears redder than the combined light from the stars,
which may be explained by a varied distribution of grain sizes. The brightness
asymmetries along the disk suggest that it is asymmetrically illuminated by the
stars due to extinction by nonuniform circumstellar material or the illuminated
surface of the disk is warped by tidal effects (or perhaps both). Localized,
time-dependent brightness variations in the disk are also seen.Comment: 28 pages, 7 figures, accepted for publication in the Astronomical
Journa
Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif
MicroRNAs modulate tumorigenesis through suppression of specific genes. As many tumour types rely on overlapping oncogenic pathways, a core set of microRNAs may exist, which consistently drives or suppresses tumorigenesis in many cancer types. Here we integrate The Cancer Genome Atlas (TCGA) pan-cancer data set with a microRNA target atlas composed of publicly available Argonaute Crosslinking Immunoprecipitation (AGO-CLIP) data to identify pan-tumour microRNA drivers of cancer. Through this analysis, we show a pan-cancer, coregulated oncogenic microRNA ‘superfamily’ consisting of the miR-17, miR-19, miR-130, miR-93, miR-18, miR-455 and miR-210 seed families, which cotargets critical tumour suppressors via a central GUGC core motif. We subsequently define mutations in microRNA target sites using the AGO-CLIP microRNA target atlas and TCGA exome-sequencing data. These combined analyses identify pan-cancer oncogenic cotargeting of the phosphoinositide 3-kinase, TGFβ and p53 pathways by the miR-17-19-130 superfamily members
Discovery of Globular Clusters in the Proto-Spiral NGC2915: Implications for Hierarchical Galaxy Evolution
We have discovered three globular clusters beyond the Holmberg radius in
Hubble Space Telescope Advanced Camera for Surveys images of the gas-rich dark
matter dominated blue compact dwarf galaxy NGC2915. The clusters, all of which
start to resolve into stars, have M_{V606} = -8.9 to -9.8 mag, significantly
brighter than the peak of the luminosity function of Milky Way globular
clusters. Their colors suggest a metallicity [Fe/H] ~ -1.9 dex, typical of
metal-poor Galactic globular clusters. The specific frequency of clusters is at
a minimum normal, compared to spiral galaxies. However, since only a small
portion of the system has been surveyed it is more likely that the luminosity
and mass normalized cluster content is higher, like that seen in elliptical
galaxies and galaxy clusters. This suggests that NGC2915 resembles a key phase
in the early hierarchical assembly of galaxies - the epoch when much of the old
stellar population has formed, but little of the stellar disk. Depending on the
subsequent interaction history, such systems could go on to build-up larger
elliptical galaxies, evolve into normal spirals, or in rare circumstances
remain suspended in their development to become systems like NGC2915.Comment: ApJ Letters accepted; 6 pages, 2 figures, 3 table
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