3,139 research outputs found
Inflationary Hubble Parameter from the Gravitational Wave Spectrum in the General Slow-roll Approximation
Improved general slow-roll formulae giving the primordial gravitational wave
spectrum are derived in the present work. Also the first and second order
general slow-roll inverse formulae giving the Hubble parameter in terms of
the gravitational wave spectrum are derived. Moreover, the general slow-roll
consistency condition relating the scalar and tensor spectra is obtained
Ascaroside Signaling Is Widely Conserved among Nematodes
Background: Nematodes are among the most successful animals on earth and include important human pathogens, yet little is known about nematode pheromone systems. A group of small molecules called ascarosides has been found to mediate mate finding, aggregation, and developmental diapause in Caenorhabditis elegans, but it is unknown whether ascaroside signaling exists outside of the genus Caenorhabditis.
Results: To determine whether ascarosides are used as signaling molecules by other nematode species, we performed a mass spectrometry-based screen for ascarosides in secretions from a variety of both free-living and parasitic (plant, insect, and animal) nematodes. We found that most of the species analyzed, including nematodes from several different clades, produce species-specific ascaroside mixtures. In some cases, ascaroside biosynthesis patterns appear to correlate with phylogeny, whereas in other cases, biosynthesis seems to correlate with lifestyle and ecological niche. We further show that ascarosides mediate distinct nematode behaviors, such as retention, avoidance, and long-range attraction, and that different nematode species respond to distinct, but overlapping, sets of ascarosides.
Conclusions: Our findings indicate that nematodes utilize a conserved family of signaling molecules despite having evolved to occupy diverse ecologies. Their structural features and level of conservation are evocative of bacterial quorum sensing, where acyl homoserine lactones (AHLs) are both produced and sensed by many species of gram-negative bacteria. The identification of species-specific ascaroside profiles may enable pheromone-based approaches to interfere with reproduction and survival of parasitic nematodes, which are responsible for significant agricultural losses and many human diseases worldwide
Strange meson-nucleon states in the quark potential model
The quark potential model and resonating group method are used to investigate
the bound states and/or resonances. The model potential consists of
the t-channel and s-channel one-gluon exchange potentials and the confining
potential with incorporating the QCD renormalization correction and the
spin-orbital suppression effect in it. It was shown in our previous work that
by considering the color octet contribution, use of this model to investigate
the low energy elastic scattering leads to the results which are in pretty
good agreement with the experimental data. In this paper, the same model and
method are employed to calculate the masses of the bound systems.
For this purpose, the resonating group equation is transformed into a standard
Schr\"odinger equation in which a nonlocal effective interaction
potential is included. Solving the Schr\"odinger equation by the variational
method, we are able to reproduce the masses of some currently concerned
states and get a view that these states possibly exist as
molecular states. For the system, the same calculation gives no support to
the existence of the resonance which was announced
recently.Comment: 15 pages, 4 figure
Formation, Manipulation, and Elasticity Measurement of a Nanometric Column of Water Molecules
Nanometer-sized columns of condensed water molecules are created by an
atomic-resolution force microscope operated in ambient conditions. Unusual
stepwise decrease of the force gradient associated with the thin water bridge
in the tip-substrate gap is observed during its stretch, exhibiting regularity
in step heights (~0.5 N/m) and plateau lengths (~1 nm). Such "quantized"
elasticity is indicative of the atomic-scale stick-slip at the tip-water
interface. A thermodynamic-instability-induced rupture of the water meniscus
(5-nm long and 2.6-nm wide) is also found. This work opens a high-resolution
study of the structure and the interface dynamics of a nanometric aqueous
column.Comment: 4 pages, 3 figure
Recommended from our members
Smartphone-based pathogen diagnosis in urinary sepsis patients.
BackgroundThere is an urgent need for rapid, sensitive, and affordable diagnostics for microbial infections at the point-of-care. Although a number of innovative systems have been reported that transform mobile phones into potential diagnostic tools, the translational challenge to clinical diagnostics remains a significant hurdle to overcome.MethodsA smartphone-based real-time loop-mediated isothermal amplification (smaRT-LAMP) system was developed for pathogen ID in urinary sepsis patients. The free, custom-built mobile phone app allows the phone to serve as a stand-alone device for quantitative diagnostics, allowing the determination of genome copy-number of bacterial pathogens in real time.FindingsA head-to-head comparative bacterial analysis of urine from sepsis patients revealed that the performance of smaRT-LAMP matched that of clinical diagnostics at the admitting hospital in a fraction of the time (~1 h vs. 18-28 h). Among patients with bacteremic complications of their urinary sepsis, pathogen ID from the urine matched that from the blood - potentially allowing pathogen diagnosis shortly after hospital admission. Additionally, smaRT-LAMP did not exhibit false positives in sepsis patients with clinically negative urine cultures.InterpretationThe smaRT-LAMP system is effective against diverse Gram-negative and -positive pathogens and biological specimens, costs less than $100 US to fabricate (in addition to the smartphone), and is configurable for the simultaneous detection of multiple pathogens. SmaRT-LAMP thus offers the potential to deliver rapid diagnosis and treatment of urinary tract infections and urinary sepsis with a simple test that can be performed at low cost at the point-of-care. FUND: National Institutes of Health, Chan-Zuckerberg Biohub, Bill and Melinda Gates Foundation
Second Order General Slow-Roll Power Spectrum
Recent combined results from the Wilkinson Microwave Anisotropy Probe (WMAP)
and Sloan Digital Sky Survey (SDSS) provide a remarkable set of data which
requires more accurate and general investigation. Here we derive formulae for
the power spectrum P(k) of the density perturbations produced during inflation
in the general slow-roll approximation with second order corrections. Also,
using the result, we derive the power spectrum in the standard slow-roll
picture with previously unknown third order corrections.Comment: 11 pages, 1 figure ; A typo in Eq. (38) is fixed ; References
expanded and a note adde
- …