254 research outputs found
Anhydrotetracycline, a novel effector for tetracycline controlled gene expression systems in eukaryotic cells
Structure of the merozoite surface protein 1 from Plasmodium falciparum
The merozoite surface protein 1 (MSP-1) is the most abundant protein on the surface of the erythrocyte-invading Plasmodium merozoite, the causative agent of malaria. MSP-1 is essential for merozoite formation, entry into and escape from erythrocytes, and is a promising vaccine candidate. Here, we present monomeric and dimeric structures of full-length MSP-1. MSP-1 adopts an unusual fold with a large central cavity. Its fold includes several coiled-coils and shows structural homology to proteins associated with membrane and cytoskeleton interactions. MSP-1 formed dimers through these domains in a concentration-dependent manner. Dimerization is affected by the presence of the erythrocyte cytoskeleton protein spectrin, which may compete for the dimerization interface. Our work provides structural insights into the possible mode of interaction of MSP-1 with erythrocytes and establishes a framework for future investigations into the role of MSP-1 in Plasmodium infection and immunity
Quantum Smoluchowski equation: Escape from a metastable state
We develop a quantum Smoluchowski equation in terms of a true probability
distribution function to describe quantum Brownian motion in configuration
space in large friction limit at arbitrary temperature and derive the rate of
barrier crossing and tunneling within an unified scheme. The present treatment
is independent of path integral formalism and is based on canonical
quantization procedure.Comment: 10 pages, To appear in the Proceedings of Statphys - Kolkata I
Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP-binding domains
Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP–binding domains
Rational Design of a Plasmid Origin That Replicates Efficiently in Both Gram-Positive and Gram-Negative Bacteria
Background: Most plasmids replicate only within a particular genus or family
Abgeschwächtes Wirtschaftswachstum und zunehmende Instabilität - Zur wirtschaftlichen Herausforderung der westlichen Industrieländer am Anfang der achtziger Jahre
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