Geophysical constraints on the thickness of the Holyrood Pluton, Avalon Peninsula, Newfoundland

The vertical extent of the Holyrood Pluton and the surrounding Harbpur Main Group of the northeastern Avalon Peninsula of Newfoundland is estimated using two-dimensional gravity and magnetic models. The models are interpreted to indicate that the maximum thickness of the Holyrood Pluton is 1.8 km and that mafic Harbour Main volcanics must exist beneath the pluton and be confined to the uppnr 2.0 km of the crust west of the Conception/Cabot Group boundary on the eastern portion of the survey area. RÉSUMÉ En utilisant des modèles à deux dimensions de gravite et de magnétisme, on a estime l’étendue verticale du pluton Holyrood et du groupe circonvoisin de Harbour Main dans l'est de la peninsule Avalon, Terre-Neuve. L'interprètation des modèles indique que lépaisseur maximale du pluton Holyrood atteint 1.8 km et que des roches volcaniques mafiques du groupe Harbour Main doivent se trouver sous le pluton et restreintes aux 2.0 km supérieurs de l'écorce se trouvant à l'ouest de la limite des groupes de Conception et de Cabot, dans la partie orientale de la région étudiée. [Traduit par le journal

Photon number resolution using a time-multiplexed single-photon detector

Photon number resolving detectors are needed for a variety of applications including linear-optics quantum computing. Here we describe the use of time-multiplexing techniques that allows ordinary single photon detectors, such as silicon avalanche photodiodes, to be used as photon number-resolving detectors. The ability of such a detector to correctly measure the number of photons for an incident number state is analyzed. The predicted results for an incident coherent state are found to be in good agreement with the results of a proof-of-principle experimental demonstration.Comment: REVTeX4, 6 pages, 8 eps figures, v2: minor changes, v3: changes in response to referee report, appendix added, 1 reference adde

Linear optics implementation of general two-photon projective measurement

We will present a method of implementation of general projective measurement of two-photon polarization state with the use of linear optics elements only. The scheme presented succeeds with a probability of at least 1/16. For some specific measurements, (e.g. parity measurement) this probability reaches 1/4.Comment: 8 page

Heralded single-photon generation using imperfect single-photon sources and a two-photon-absorbing medium

We propose a setup for a heralded, i.e. announced generation of a pure single-photon state given two imperfect sources whose outputs are represented by mixtures of the single-photon Fock state $\ket{1}$ with the vacuum $\ket{0}$. Our purification scheme uses beam splitters, photodetection and a two-photon-absorbing medium. The admixture of the vacuum is fully eliminated. We discuss two potential realizations of the scheme.Comment: 22 pages, 8 figures (LaTeX). In version v2 we have slightly modified our setup so as to increase the success probability of single-photon generation by a factor of two. In addition, in an appendix we discuss alternative realizations of single-photon generation without a Mach-Zehnder interferometer. Three new figures have been added. Version v3 is a revised version published in Phys. Rev. A. It contains numerous minor corrections and clarifications. A new figure has been added in order to clarify our convention regarding labelling the field modes. The action of the beam splitters in the Schroedinger picture is introduced. A new reference has been include

Demonstration of Non-Deterministic Quantum Logic Operations using Linear Optical Elements

Knill, Laflamme, and Milburn recently showed that non-deterministic quantum logic operations could be performed using linear optical elements, additional photons (ancilla), and post-selection based on the output of single-photon detectors [Nature 409, 46 (2001)]. Here we report the experimental demonstration of two logic devices of this kind, a destructive controlled-NOT (CNOT) gate and a quantum parity check. These two devices can be combined with a pair of entangled photons to implement a conventional (non-destructive) CNOT that succeeds with a probability of 1/4.Comment: 4 pages, 5 figures; Minor change

Conditional linear-optical measurement schemes generate effective photon nonlinearities

We provide a general approach for the analysis of optical state evolution under conditional measurement schemes, and identify the necessary and sufficient conditions for such schemes to simulate unitary evolution on the freely propagating modes. If such unitary evolution holds, an effective photon nonlinearity can be identified. Our analysis extends to conditional measurement schemes more general than those based solely on linear optics.Comment: 16 pages, 2 figure

Two-Photon Entanglement and EPR Experiments Using Type-2 Spontaneous Parametric Down Conversion

Simultaneous entanglement in spin and space-time of a two-photon quantum state generated in type-2 spontaneous parametric down-conversion is demonstrated by the observation of quantum interference with 98% visibility in a simple beam-splitter (Hanburry Brown-Twiss) anticorrelation experiment. The nonlocal cancellation of two-photon probability amplitudes as a result of this double entanglement allows us to demonstrate two different types of Bell's inequality violations in one experimental setup

Investigation of Somatic Mutations in Human Brains Targeting Genes Associated With Parkinson's Disease

BACKGROUND: Somatic single nucleotide variant (SNV) mutations occur in neurons but their role in synucleinopathies is unknown. AIM: We aimed to identify disease-relevant low-level somatic SNVs in brains from sporadic patients with synucleinopathies and a monozygotic twin carrying LRRK2 G2019S, whose penetrance could be explained by somatic variation. METHODS AND RESULTS: We included different brain regions from 26 Parkinson's disease (PD), one Incidental Lewy body, three multiple system atrophy cases, and 12 controls. The whole SNCA locus and exons of other genes associated with PD and neurodegeneration were deeply sequenced using molecular barcodes to improve accuracy. We selected 21 variants at 0.33–5% allele frequencies for validation using accurate methods for somatic variant detection. CONCLUSIONS: We could not detect disease-relevant somatic SNVs, however we cannot exclude their presence at earlier stages of degeneration. Our results support that coding somatic SNVs in neurodegeneration are rare, but other types of somatic variants may hold pathological consequences in synucleinopathies