Lower bound for energies of harmonic tangent unit-vector fields on convex polyhedra

We derive a lower bound for energies of harmonic maps of convex polyhedra in $\R^3$ to the unit sphere $S^2,$ with tangent boundary conditions on the faces. We also establish that $C^\infty$ maps, satisfying tangent boundary conditions, are dense with respect to the Sobolev norm, in the space of continuous tangent maps of finite energy.Comment: Acknowledgment added, typos removed, minor correction

Interaction of inflammatory cytokines and erythropoeitin in iron metabolism and erythropoiesis in anaemia of chronic disease

In chronic inflammatory conditions increased endogenous release of specific cytokines (TNFα, IL-1, IL-6, IFNγ and others) is presumed. It has been shown that those of monocyte lineage play a key role in cytokine expression and synthesis. This may be associated with changes in iron metabolism and impaired erythropoiesis and may lead to development of anaemia in patients with rheumatoid arthritis. Firstly, increased synthesis of acute phase proteins, like ferritin, during chronic inflammation is proposed as the way by which the toxic effect of iron and thereby the synthesis of free oxy-radicals causing the damage on the affected joints, may be reduced. This is associated with a shift of iron towards the mononuclear phagocyte system which may participate in the development of anaemia of chronic disease. Secondly, an inhibitory action of inflammatory cytokines (TNFα, IL-1), on proliferation and differentiation of erythroid progenitors as well as on synthesis of erythropoietin has been shown, thereby also contributing to anaemia. Finally, chronic inflammation causes multiple, complex disturbances in the delicate physiologic equilibrium of interaction between cytokines and cells (erythroid progenitors, cells of mononuclear phagocyte system and erythropoietin producing cells) leading to development of anaemia of chronic disease (Fig. 1)

EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial

More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369

Infectious ideas: modelling the diffusion of ideas across social networks

Will the practice of collecting wild honey wearing no clothes become a widespread practice in Zimbabwe? Or will beekeeping take over as the main way that people acquire honey? Both practices impact on forest resources; how can the foresters influence the uptake of these ideas?. This paper describes an exploratory modelling study investigating how social network patterns affect the way ideas spread around communities. It concludes that increasing the density of social networks increases the spread of successful ideas whilst speeding the loss of ideas with no competitive advantage. Some different kinds of competitive advantage are explored in the context of forest management and rural extension

The Balance of Power in Household Decision-Making: Encouraging News on Gender in Southern Sulawesi

SummaryAnalyses of intra-household decision-making in Sulawesi are linked to gender issues shown to affect involvement in landscape management. These include agriculture, food, money, life chances, and attitudes toward domestic violence. The picture portrayed is encouraging, showing the social sophistication of a group often marginalized: This group shows considerable female involvement in decision-making and strongly democratic elements. We identify three issues that need greater attention—for equitable landscape management to result: women’s spheres of decision-making must be ascertained and taken into account, men’s involvement in care needs to expand, and women’s agency requires enhancement and external support