59 research outputs found
Observation of Magnetic Flux Generated Spontaneously During a Rapid Quench of Superconducting Films
We report observations of spontaneous formation of magnetic flux lines during
a rapid quench of YBaCuO films through T. This
effect is predicted according to the Kibble-Zurek mechanism of creation of
topological defects of the order parameter during a symmetry-breaking phase
transition. Our previous experiment, at a quench rate of 20K/sec, gave null
results. In the present experiment, the quench rate was increased to
\TEXTsymbol{>} 10 K/sec. Within experimental resolution, the dependence
of the measured flux on the cooling rate is consistent with the prediction
Genetic interaction mapping informs integrative structure determination of protein complexes
Determining structures of protein complexes is crucial for understanding cellular functions. Here, we describe an integrative structure determination approach that relies on in vivo measurements of genetic interactions. We construct phenotypic profiles for point mutations crossed against gene deletions or exposed to environmental perturbations, followed by converting similarities between two profiles into an upper bound on the distance between the mutated residues. We determine the structure of the yeast histone H3-H4 complex based on similar to 500,000 genetic interactions of 350 mutants. We then apply the method to subunits Rpb1-Rpb2 of yeast RNA polymerase II and subunits RpoB-RpoC of bacterial RNA polymerase. The accuracy is comparable to that based on chemical cross-links; using restraints from both genetic interactions and cross-links further improves model accuracy and precision. The approach provides an efficient means to augment integrative structure determination with in vivo observations
DEAR1 Is a Dominant Regulator of Acinar Morphogenesis and an Independent Predictor of Local Recurrence-Free Survival in Early-Onset Breast Cancer
Ann Killary and colleagues describe a new gene that is genetically altered in breast tumors, and that may provide a new breast cancer prognostic marker
Metschnikowia bicuspidata dominates in Taiwanese cold-weather yeast infections of Macrobrachium rosenbergii
Diseases of Aquatic Organisms753191-19
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